The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sun, 19 Jul 2026 23:50:57 GMT 2026 NEJM Group en-us 1440 Among patients with multivessel coronary artery disease who were in stable condition 1 year after stenting, an additional year of DAPT led to a lower risk of ischemic events than aspirin alone, without increased bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2517588?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 Jinwei Tian, Zhuozhong Wang, Yan Wang, Fan Wang, Xiang Peng, Jiandong Xiao, Chunjie Li, Xinyu Hou, Qian Tong, Xi Yu, Guangren Gao, Peng Zhao, Jie Zhao, Ying Liu, Zhexue Qin, Haijing Lu, Shujiang Zhang, Shengli Li, Zhiyuan Weng, Huifang Tang, Yuquan He, Chunpeng Zhang, Yong Liu, Jun Jiang, Jinying Zhang, Lei Cai, Lili Xiu, Gary S. Mintz, Duolao Wang, Gregg W. Stone, Bo Yu, the DAPT-MVD Trial Investigators* 2026-07-16 Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease The appropriate duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) has remained the subject of a central debate in cardiovascular medicine. DAPT is intended to mitigate ischemic risk, but its maintenance warrants balancing the benefit against the concomitant risk of hemorrhage.1 Consequently, determining the appropriate... https://www.nejm.org/doi/full/10.1056/NEJMe2604885?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2604885 Kyung Woo Park, Jeehoon Kang 2026-07-16 Balancing the Scales — Extended DAPT in Coronary Artery Disease A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. https://www.nejm.org/doi/full/10.1056/NEJMicm2505469?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2505469 Maithili Charan Gattu, Mehul K 2026-07-16 Descending Thoracic Aortic Aneurysm This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies. https://www.nejm.org/doi/full/10.1056/NEJMra2502459?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2502459 Theodore E. Warkentin, Andreas Greinacher 2026-07-13 Platelet-Activating Anti–Platelet Factor 4 Disorders After total hip or knee arthroplasty, aspirin alone was noninferior to rivaroxaban followed by aspirin in preventing symptomatic venous thromboembolism, with a similarly low risk of bleeding complications. https://www.nejm.org/doi/full/10.1056/NEJMoa2603649?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2603649 Sudeep Shivakumar, Davide Matino, David Zukor, Susan R. Kahn, George Vincent, Raman Mundi, Pascal-Andre Vendittoli, Mohammad Refaei, Eric Bohm, Michael Tanzer, Stéphane Pelet, Glen Richardson, James Powell, Rick Ikesaka, James Douketis, Sarah Ward, Paul Kim, Stephen Mann, Susan Pleasance, Jocelyn Cormier, Pantelis Andreou, Kara Matheson, Chris Theriault, Carol West, David Anderson, Peter L. Gross, the EPCAT III Trial Investigators* 2026-07-12 Rivaroxaban Then Aspirin vs. Aspirin Alone after Total Hip or Knee Arthroplasty This interactive feature describes a 73-year-old man with a history of heart failure who presented to the ED with a rash, weight gain, dyspnea, and new-onset visible hematuria. Test your diagnostic and therapeutic skills at NEJM.org. https://www.nejm.org/doi/full/10.1056/NEJMimc2514359?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMimc2514359 Matthew C. Johnson, Anand Vaidya, Adam L. Beckman, Ramón Rodriguez, Claire Avillach, David Mount 2026-07-09 A Rash and Red Urine Updated estimates of the prevalence of CKD in the United States indicate that the overall national burden of CKD has remained stable, but an increasing proportion is associated with diabetes. https://www.nejm.org/doi/full/10.1056/NEJMc2518565?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518565 Sophie E. Claudel, Ashish Verma 2026-07-09 Trends and Prevalence of Chronic Kidney Disease in the United States In a randomized trial, FFRangio (fractional flow reserve derived from angiography) was noninferior to pressure-wire–guided assessment in reducing risk among patients with intermediate coronary stenosis. https://www.nejm.org/doi/full/10.1056/NEJMoa2600949?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600949 William F. Fearon, Allen Jeremias, Guy Witberg, Rasha Al-Lamee, David J. Cohen, Amir Kaki, Rahul P. Sharma, Robert W. Yeh, Bassem M. Chehab, Michael C. Kim, Hiromasa Otake, Rajiv Tayal, Hitoshi Matsuo, Margaret McEntegart, Ankitkumar K. Patel, Yader Sandoval, Karim M. Al-Azizi, Kazuhiro Dan, Louai Razzouk, Stephane Fournier, Alexandra Popma, Jeffrey J. Popma, Duzhi Zhao, Bjorn Redfors, Mahesh V. Madhavan, Ran Kornowski, Martin B. Leon, Ajay J. Kirtane, the ALL-RISE Investigators* 2026-07-02 Angiography-Derived Fractional Flow Reserve to Guide PCI Among patients with intermediate coronary lesions, angiography-guided revascularization was noninferior to pressure-wire–based guidance with respect to death, myocardial infarction, or revascularization. https://www.nejm.org/doi/full/10.1056/NEJMoa2601841?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601841 Joost Daemen, Jari A. van der Eijk, Marco Barbierato, Robert A. Byrne, Paolo Canova, Giovanni L. De Maria, Eric Van Belle, Ignacio Amat-Santos, Antonio Mangieri, Thomas Hovasse, Manel Sabaté, Ronan Margey, Simone Biscaglia, Fernando Rivero, Domenico D’Amario, Youssef S. Abdelwahed, Rohit M. Oemrawsingh, Raul Moreno, James Cockburn, Luca Testa, Ton de Vries, Ulf Landmesser, Adrian P. Banning, Jan G.P. Tijssen, Ernest Spitzer, the FAST III Investigators* 2026-07-02 Angiography-Based Physiology to Guide Coronary Revascularization Randomized trials have shown that physiological assessment of coronary lesions with a coronary pressure wire improves outcomes and reduces unnecessary percutaneous coronary intervention (PCI) as compared with angiography-guided care.1 However, despite class I guideline recommendations, coronary physiological assessment remains underused.2 Angiography-derived fractional flow reserve (FFR) has... https://www.nejm.org/doi/full/10.1056/NEJMe2603396?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603396 Gianluca Campo 2026-07-02 Toward Broader Adoption of Coronary Physiological Assessment The author describes the scientific foundations of two trials comparing how noninvasive and invasive assessments of fractional flow reserve affect clinical outcomes. https://www.nejm.org/doi/full/10.1056/NEJMe2602134?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602134 Amanda Randles 2026-07-02 Science behind the Study: Physiological Assessment of Coronary Artery Disease Since the introduction of percutaneous coronary intervention (PCI) in the late 1970s, the field has evolved immensely with respect to indications, devices, and adjunctive pharmacotherapy. One of the defining transitions was the move from anatomy-guided PCI, based largely on subjective angiographic eyeballing, to physiology-guided revascularization. The Fractional Flow Reserve versus... https://www.nejm.org/doi/full/10.1056/NEJMe2603714?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603714 Yiannis S. Chatzizisis 2026-07-02 Redefining Physiology in the Cardiac Catheterization Laboratory Patients with shrinking cognitive bandwidth may feel their disability keenly in daily life, even if they can pass a controlled test of cognitive capacity. How should clinicians approach and care for them? https://www.nejm.org/doi/full/10.1056/NEJMp2600769?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600769 Jan Stubberud 2026-07-02 The Invisible Load of Cognitive Symptoms In patients with persistent atrial fibrillation, first-line treatment with pulsed field ablation reduced the recurrence of atrial arrhythmias at 12 months as compared with antiarrhythmic drugs. https://www.nejm.org/doi/full/10.1056/NEJMoa2600929?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600929 Oussama M. Wazni, K.R. Julian Chun, Devi G. Nair, Ante Anic, Mattias Duytschaever, Jonathan Chrispin, Anish Amin, Olujimi A. Ajijola, Douglas N. Gibson, Moussa Mansour, Jonathan P. Piccini, Andrea Natale, Auroa Badin, Joaquin Osca, Jonathan Dukes, Karan Bhalla, Ayman Hussein, Todd Senn, Stanislav Weiner, Nitesh Sood, Antonio Dello Russo, Ashish Sadhu, Jason Meyers, Kevin Trulock, Mark T.K. Tam, David B. DeLurgio, Jean Champagne, Saverio Iacopino, Brian Kwan, Elizabeth M. Albrecht, Sheryl McCammon, Ann C. Garlitski, Brad S. Sutton, Kenneth M. Stein, Jason G. Andrade, the AVANT GUARD Study Investigators* 2026-06-25 Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation In a cluster-randomized trial involving patients having major noncardiac surgery, tranexamic acid reduced the need for red-cell transfusion during hospitalization and was noninferior to placebo for venous thromboembolism within 90 days. https://www.nejm.org/doi/full/10.1056/NEJMoa2515820?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515820 Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, Salmaan Kanji, Peter Greenstreet, Meghan Andrews, Sinziana Avramescu, Hema S. Bagry, Robert Balshaw, Jayesh Daya, Kaitlin Duncan, Christopher C. Harle, Eric Jacobsohn, Tina Kerelska, Marshall Pitz, Paul Komenda, Sarah McIsaac, Tim Ramsay, Tarit Saha, Alan Tinmouth, Angela Recio, Daniel Szoke, Marshall Tenenbein, Sarah Slagerman, Dayna Solvason, Robert Talarico, Dean A. Fergusson, Ryan Zarychanski 2026-06-25 Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery A 47-year-old man with heart failure with a reduced ejection fraction and an ICD for the primary prevention of sudden cardiac death presented with an unheralded syncopal event, which had been captured by video surveillance at work. https://www.nejm.org/doi/full/10.1056/NEJMicm2600597?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2600597 Michael Thomas Garcia, Alec Bijan Rezigh 2026-06-25 Unheralded Syncope from Ventricular Arrhythmia Atrial fibrillation is one of the most common cardiac conditions and is associated with important adverse effects on quality of life, major cardiovascular and neurovascular outcomes, survival, and health care use. Improved outcomes have been seen with pursuit of sinus rhythm,1 and catheter ablation has been more effective... https://www.nejm.org/doi/full/10.1056/NEJMe2606012?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2606012 John L. Sapp 2026-06-25 Catheter Ablation for Persistent Atrial Fibrillation Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific evidence on the overall safety, efficacy,... https://www.nejm.org/doi/full/10.1056/NEJMe2603105?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603105 Michael F. Murphy, Ian Roberts 2026-06-25 TRACTION for Greater Surgical Use of Tranexamic Acid Many countries rely on air-quality indices to inform the public and help protect people during short-term increases in air pollution. Their use has important societal and economic implications. https://www.nejm.org/doi/full/10.1056/NEJMp2601256?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601256 Robert D. Brook, Sanjay Rajagopalan 2026-06-25 Improving Global Air-Quality Indices — The WHO’s New Roadmap The EPA has decided to stop considering the monetary value of public health benefits in federal rulemaking related to air pollution. This decision could have profound health consequences. https://www.nejm.org/doi/full/10.1056/NEJMp2601300?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601300 Arianne Teherani, Rupa Basu, Sheri Weiser 2026-06-25 When Health Costs No Longer Count — Air Pollution and EPA Rulemaking