The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Wed, 17 Jun 2026 02:01:35 GMT 2026 NEJM Group en-us 1440 Among patients with unprotected left main coronary artery disease, intravascular ultrasound–guided PCI did not result in a lower risk of ischemic events or death than angiography-guided PCI. https://www.nejm.org/doi/full/10.1056/NEJMoa2600440?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600440 Luca Testa, Jose Maria De la Torre Hernandez, Giovanni Luigi De Maria, Daniel A. Jones, Pablo Piñon-Esteban, Gianluca Campo, Bruno Garcia del Blanco, Manuel Pan, Tamara Garcia-Camarero, Gennaro Sardella, Peter O’Kane, John P. Greenwood, Flavio L. Ribichini, Irene Pescetelli, Alfonso Ielasi, Iñigo Lozano, James Cockburn, Jacopo A. Oreglia, Azfar G. Zaman, Francesco Bedogni, Wietze Lindeboom, Jan G.P. Tijssen, Ernest Spitzer, Adrian P. Banning, the OPTIMAL Investigators* 2026-06-11 IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease In a randomized trial involving patients undergoing complex high-risk PCI, the risk of target-vessel failure (a composite outcome) was not lower with intravascular ultrasound guidance than with angiography guidance. https://www.nejm.org/doi/full/10.1056/NEJMoa2601521?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601521 Roberto Diletti, Joost Daemen, Benjamin Faurie, Marco Barbierato, Didier Tchétché, Thomas Hovasse, Koen Teeuwen, Jin M. Cheng, Martin Landt, Gianluca Campo, Johan Bennett, Fernando Alfonso, Kambis Mashayekhi, Raul Moreno, Youssef S. Abdelwahed, Ton Heestermans, Jose M. de la Torre Hernandez, John C. Murphy, Ignacio Amat-Santos, Joseph Dens, Alfonso Franzé, David M. Leistner, Angie Ghattas, James C. Spratt, Adrian P. Banning, Jan G.P. Tijssen, Ernest Spitzer, Nicolas M. Van Mieghem, the IVUS-CHIP Investigators* 2026-06-11 Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI The authors review current strategies for anticoagulation reversal in major bleeding events or urgent surgery as well as specific antidotes, limits of available evidence, thrombotic risks, unmet therapeutic needs, and ongoing research. https://www.nejm.org/doi/full/10.1056/NEJMra2506021?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2506021 Bianca Rocca, Hugo ten Cate 2026-06-11 Antidotes for Anticoagulation Reversal A 14-year-old girl was admitted to the hospital because of hypertension and headache. She had hypokalemia, an elevated blood level of C-reactive protein, and an elevated erythrocyte sedimentation rate. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866 Rachel R. Osborn, Jonathan S. Hausmann, Weizhen Tan, Evan J. Zucker 2026-06-11 Case 16-2026: A 14-Year-Old Girl with Hypertension Despite recognition that racial and ethnic categories are poor proxies for genetic diversity, race is still used to guide pharmaceutical use, posing risks of ineffectively low or dangerously high dosing. https://www.nejm.org/doi/full/10.1056/NEJMp2516090?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516090 Harsimar K. Ahuja, David S. Jones, Winfred W. Williams 2026-06-11 Prescription without Precision — Dangers of Dosing on the Basis of Race as Biology Treatment of the left main coronary artery with percutaneous coronary intervention (PCI) in the absence of previous surgical revascularization, also referred to as an unprotected left main coronary artery PCI, is one of the riskier tasks that interventional cardiologists are asked to perform. Stent implantation in the left main coronary... https://www.nejm.org/doi/full/10.1056/NEJMe2602959?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602959 Frederick Welt 2026-06-11 Seeing the Left Main Coronary Artery Clearly — Is IVUS Always Necessary? The use of intravascular ultrasound (IVUS) imaging for assessment of the coronary arteries has an almost 40-year history. In an editorial comment on an early ex vivo assessment of the accuracy of IVUS in evaluating human coronary arteries, Yock and Linker1 posed three questions that remain relevant today:... https://www.nejm.org/doi/full/10.1056/NEJMe2603397?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603397 Adnan Kastrati 2026-06-11 IVUS — A Zigzag Path to Success Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy. https://www.nejm.org/doi/full/10.1056/NEJMoa2513814?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513814 The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group 2026-06-10 Conservative Oxygen for Unresponsive Patients after Cardiac Arrest In a cluster-randomized trial involving patients having major noncardiac surgery, tranexamic acid reduced the need for red-cell transfusion during hospitalization and was noninferior to placebo for venous thromboembolism within 90 days. https://www.nejm.org/doi/full/10.1056/NEJMoa2515820?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515820 Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, Salmaan Kanji, Peter Greenstreet, Meghan Andrews, Sinziana Avramescu, Hema S. Bagry, Robert Balshaw, Jayesh Daya, Kaitlin Duncan, Christopher C. Harle, Eric Jacobsohn, Tina Kerelska, Marshall Pitz, Paul Komenda, Sarah McIsaac, Tim Ramsay, Tarit Saha, Alan Tinmouth, Angela Recio, Daniel Szoke, Marshall Tenenbein, Sarah Slagerman, Dayna Solvason, Robert Talarico, Dean A. Fergusson, Ryan Zarychanski 2026-06-10 Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific evidence on the overall safety, efficacy,... https://www.nejm.org/doi/full/10.1056/NEJMe2603105?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603105 Michael F. Murphy, Ian Roberts 2026-06-10 TRACTION for Greater Surgical Use of Tranexamic Acid In a phase 3 trial involving adults with obesity but without diabetes, the glucagon receptor–GLP-1 receptor dual agonist survodutide led to significantly greater reductions in body weight than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2600751?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600751 Carel W. le Roux, Sean Wharton, Elena Startseva, Isabel M. Kloer, Samina Ajaz Hussain, Anna Unseld, Biykem Bozkurt, Jamy D. Ard, Harold E. Bays, Pawel Bogdański, Elif I. Ekinci, Ania M. Jastreboff, Linong Ji, Wataru Ogawa, Sue D. Pedersen, Kirsi H. Pietiläinen, Naveed Sattar, Jochen Seufert, Kaj Stenlöf, André P. van Beek, Roman Vangoitsenhoven, Martina Brueckmann, Ramy Younes, Lee M. Kaplan, the SYNCHRONIZE-1 Investigators* 2026-06-07 Survodutide Once Weekly for the Treatment of Adults with Obesity In adults without diabetes who had chronic kidney disease, the nonsteroidal mineralocorticoid receptor antagonist finerenone led to a slower decrease in the estimate glomerular filtration rate than placebo over 32 months. https://www.nejm.org/doi/full/10.1056/NEJMoa2604625?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2604625 Hiddo J.L. Heerspink, Brendon L. Neuen, Rajiv Agarwal, David Z.I. Cherney, Carolyn S.P. Lam, Katherine R. Tuttle, Christoph Wanner, Pantelis Sarafidis, Niels Jongs, J. David Smeijer, Meike Brinker, Nicole Rethemeier, Patrick Schloemer, Paula Vesterinen, David Goldsbury, Sara Dizayee, Jon W. Mares, Vlado Perkovic, the FIND-CKD Investigators* 2026-06-04 Finerenone in Persons with Chronic Kidney Disease without Diabetes In patients with atrial fibrillation, left atrial appendage closure was noninferior to NOACs in an analysis of death from cardiovascular causes, stroke, or systemic embolism and was superior for non–procedure-related bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2517213?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2517213 Shephal K. Doshi, Saibal Kar, Devi G. Nair, Thomas Waggoner, Himanshu Agarwal, Mehran Moussavian, Amir Kashani, Saumil Oza, Leon Feldman, Ashish Sadhu, David DeLurgio, Oluseun Alli, Jens Erik Nielsen-Kudsk, Masanori Yamamoto, Mohamad Alkhouli, A. John Camm, Megan Coylewright, C. Michael Gibson, Christopher B. Granger, Mahmut Edip Gurol, Kenneth C. Huber, Moussa Mansour, Andrea Natale, Stuart J. Pocock, Vivek Y. Reddy, Walid I. Saliba, Federico M. Asch, Scott Wehrenberg, Kate Frost, Thomas Christen, Brad S. Sutton, Kenneth M. Stein, Martin B. Leon, Kenneth A. Ellenbogen, the CHAMPION-AF Investigators* 2026-06-04 Left Atrial Appendage Closure or Anticoagulation for Atrial Fibrillation Owing to the fact that most thromboembolic complications that are attributed to atrial fibrillation originate in the left atrial appendage,1 therapies targeting the anatomical structure that might spare systemic harms are theoretically attractive. Randomized trials of left atrial appendage closure previously garnered an American College of Cardiology–American Heart... https://www.nejm.org/doi/full/10.1056/NEJMe2603846?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603846 Gregory M. Marcus 2026-06-04 Left Atrial Appendage Closure — Should Recommendations Be Expanded? How did a drug for congestive heart failure get approved and marketed for Black people only? https://www.nejm.org/doi/full/10.1056/NEJMp2601978?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601978 2026-06-04 Intention to Treat — Season 2: The Race Equation: BiDil — The Story of the Black Pill — ITT Episode 2.5 Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to... https://www.nejm.org/doi/full/10.1056/NEJMe2605851?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2605851 Yoshiya Tanaka 2026-06-03 Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting In patients with pulmonary embolism, ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes than anticoagulation alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2516567?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516567 Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, Andrew S.P. Sharp, Fionnuala Ní Áinle, Michael R. Jaff, Stefano Barco, Samuel Z. Goldhaber, Nils Kucher, Irene M. Lang, Irene Schmidtmann, Keith M. Sterling, Aleksander Araszkiewicz, Vishal Arora, Rafael Cires-Drouet, John Coghlan, Lukas Hobohm, Wulf D. Ito, Kurt Jacobson, Christoph Kaiser, Grzegorz Kopec, Kristin Marx, Samuel McElwee, Nicolas Meneveau, Peter Monteleone, Jose M. Montero-Cabezas, Christoph B. Olivier, John Park, Marek Roik, Rahul Sakhuja, Andi Tego, Markus Theurl, Gautam Visveswaran, Jan Albert Vos, Michael N. Young, Federico M. Asch, Stavros V. Konstantinides, the HI-PEITHO Investigators* 2026-05-28 Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism An open-label phase 1–2 study of biologic ventricular assist tissue in patients with heart failure showed increased target-wall thickness and gains in the left ventricular ejection fraction plus a reduction in symptoms at 3 months. https://www.nejm.org/doi/full/10.1056/NEJMoa2513525?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513525 Wolfram-Hubertus Zimmermann, Stephan Ensminger, Ingo Kutschka, Christina Paitazoglou, Tim Seidler, Sören Brandenburg, Stefan D. Anker, Niklas Bader, Leonard Bergau, Felix Bremmer, Pedro G. Diogo, Ingo Eitel, Buntaro Fujita, Birgit Gerecke, Gerd Hasenfuß, Kristian Hellenkamp, Christoph Hermann-Lingen, Ahmad-Fawad Jebran, Dominik Jurczyk, Rainer Knaus, Tobias Legler, Joachim Lotz, Marius Placzek, Thomas Pühler, Joachim Riggert, Monika Sadlonova, Roza Saraei, Philipp Ströbel, Malte Tiburcy, Christian Ullrich, Jens-Uwe Voigt, Florian Walker, Bernd Wollnik, Gökhan Yigit, Tim Friede, the BioVAT-HF Investigators† 2026-05-28 Stem-Cell–Derived Biologic Ventricular Assist Tissue in Heart Failure This Double Take video outlines the five risk factors for cardiovascular disease and reviews strategies for blood-pressure control to reduce morbidity and mortality. https://www.nejm.org/doi/full/10.1056/NEJMp2516850?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516850 Holly Biola, Sadiya S. Khan, Donald Lloyd-Jones, Neha J. Pagidipati, Willie McDonald, Patrick G. O’Malley 2026-05-28 Double Take: Cardiovascular Risk Factors — Hypertension This interactive feature describes a 71-year-old woman with a history of type 2 diabetes, heart failure with a reduced ejection fraction, and stage 3 CKD who presented to the ED with worsening pain in her left buttock that had begun 1 week earlier. Test your diagnostic and therapeutic skills at... https://www.nejm.org/doi/full/10.1056/NEJMimc2514358?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMimc2514358 Josephine Kahn, Anand Vaidya, David Roach, Joaquim Michael Havens, Victoria Thomas, Bruce Levy 2026-05-28 Cutting to the Chase