The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sun, 12 Apr 2026 11:03:42 GMT 2026 NEJM Group en-us 1440 Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. https://www.nejm.org/doi/full/10.1056/NEJMoa2600283?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600283 Yong-Joon Lee, Seung-Jun Lee, Jin Won Kim, Sang-Hyup Lee, Gwang-Sil Kim, Jae Hyoung Park, Jin-Man Cho, Woong Chol Kang, Hyuck-Jun Yoon, Won Ho Kim, Seung-Jin Lee, Jin Bae Lee, Ji-Yong Jang, Sanghoon Shin, Ik Hyun Park, Sung Uk Kwon, Sunwon Kim, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Byeong-Keuk Kim, the Ez-PAVE Investigators* 2026-04-09 Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease Among low-income patients with hypertension, a multifaceted, team-based strategy resulted in a greater reduction in systolic blood pressure than enhanced usual care. https://www.nejm.org/doi/full/10.1056/NEJMoa2504068?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2504068 Katherine T. Mills, Marie Krousel-Wood, Erin M. Peacock, Jing Chen, Farah Allouch, Amy K. Carreras, Siyi Geng, Alecia Cyprian, Gerrelda Davis, Sonja R. Fuqua, Darie Gilliam, Angelique Greer, Tammy Mitchell, Wylea Gray-Winfrey, Shondra Williams, Gary M. Wiltz, Keith L. Winfrey, Hua He, Paul K. Whelton, Jiang He 2026-04-09 Multifaceted Strategies for Hypertension Control in Low-Income Patients In 2022, more than 130,000 deaths in the United States were primarily attributable to high blood pressure and were largely preventable; this number represents a near doubling since 2012.1 Despite the availability of multiple effective, safe, and inexpensive therapies for lowering blood pressure, fewer than half of U.S.... https://www.nejm.org/doi/full/10.1056/NEJMe2518341?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518341 Sadiya S. Khan, Mark D. Huffman 2026-04-09 Systems-Based Success for Hypertension A 70-year-old woman presented with a racing heart, fatigue, dyspnea, and leg edema. One month earlier, percutaneous catheter ablation for atrial fibrillation had been performed. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513542?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513542 Thomas K. Varghese Jr., Eliza D. Hompe, Shaan S. Khurshid, Jo-Anne O. Shepard, Eriberto Michel, Uma M. Sachdeva 2026-04-09 Case 10-2026: A 70-Year-Old Woman with a Racing Heart, Fatigue, and Dyspnea In patients with atherosclerotic cardiovascular disease, lowering lipid levels is critical for reducing the risk of recurrent cardiovascular disease. International guidelines endorse the targeting of a low-density lipoprotein (LDL) cholesterol level of less than 55 mg per deciliter for secondary prevention of atherosclerotic cardiovascular disease in patients at high risk... https://www.nejm.org/doi/full/10.1056/NEJMe2601725?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2601725 Jeffrey L. Probstfield, Kelley R.H. Branch 2026-04-09 Paving the Road toward Targeted Lipid Lowering Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. https://www.nejm.org/doi/full/10.1056/NEJMoa2513310?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513310 Ulf Landmesser, Carsten Skurk, Paulus Kirchhof, Thorsten Lewalter, Johannes Hartung, Andi Rroku, Burkert Pieske, Johannes Brachmann, Ibrahim Akin, Claudius Jacobshagen, Benjamin Meder, Andreas Zeiher, Stefan D. Anker, Holger Thiele, Stefan Blankenberg, Steffen Massberg, Heribert Schunkert, Norbert Frey, Alexander Joost, Martin Bergmann, Ralph Stephan von Bardeleben, Tim Friede, Marius Placzek, Anna Suling, Karl Georg Haeusler, Matthias Endres, Karl Wegscheider, Leif-Hendrik Boldt, Ingo Eitel, the CLOSURE-AF Trial Investigators* 2026-04-02 Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation Among patients with a preserved ejection fraction at least 1 year after myocardial infarction, stopping beta-blockers was noninferior to continuing therapy with respect to major clinical outcomes. https://www.nejm.org/doi/full/10.1056/NEJMoa2601005?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601005 Ki Hong Choi, Danbee Kang, Weon Kim, Joon-Hyung Doh, Juhan Kim, Yong Hwan Park, Sung Gyun Ahn, Jong Pil Park, Sang Min Kim, Byung Ryul Cho, Chang-Wook Nam, Jang Hyun Cho, Seung-Jae Joo, Jon Suh, Jin-Ok Jeong, Woo Jin Jang, Choong Won Goh, Chang-Hwan Yoon, Jin-Yong Hwang, Seong-Hoon Lim, Sang Rok Lee, Eun-Seok Shin, Byung Jin Kim, Cheol Woong Yu, Sung-Ho Her, Hyun Kuk Kim, Kyu Tae Park, Juwon Kim, Jihoon Kim, Taek Kyu Park, Joo Myung Lee, Juhee Cho, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Eliseo Guallar, Joo-Yong Hahn, the SMART-DECISION Investigators* 2026-04-02 Discontinuation of Beta-Blocker Therapy after Myocardial Infarction Untreated atrial fibrillation carries an approximately 3 to 5% annual risk of ischemic stroke. Long-term oral anticoagulation therapy decreases this risk to 1.7% with warfarin and to 1.5% with edoxaban, as shown in the ENGAGE AF-TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction... https://www.nejm.org/doi/full/10.1056/NEJMe2518067?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518067 Petr Widimský 2026-04-02 Left Atrial Appendage Closure — Another Overused Method in Cardiology? Chronologic age plays an outsized role in various aspects of medicine. Yet people of the same age can differ dramatically when it comes to aging-related risk factors. https://www.nejm.org/doi/full/10.1056/NEJMp2516973?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516973 Martin G. Lee 2026-04-02 The Age Illusion — Limitations of Chronologic Age in Medicine In a simulation involving 15 healthy trainees, slowing respiration to 10 seconds per breath produced pulsus measurements exceeding 20 mm Hg, enabling improved teaching simulation and understanding of underlying physiology. https://www.nejm.org/doi/full/10.1056/NEJMc2518685?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518685 Rona Yu, Glen Cook, J. Edwin Atwood 2026-04-02 Simulating and Teaching the Physiology of Pulsus Paradoxus In a 10-patient feasibility study, heart digital twins were used to guide VT ablation. Afterward, VT was noninducible in all patients; at a mean follow-up of 13 months, 8 patients were free of recurrence, without drug therapy. https://www.nejm.org/doi/full/10.1056/NEJMc2517822?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2517822 Jonathan Chrispin, Adityo Prakosa, Eugene Kholmovski, Aravindan Kolandaivelu, Amanda Barcelon, Konstantinos N. Aronis, Ronald D. Berger, Hugh Calkins, Natalia Trayanova 2026-04-02 Digital Twin–Guided Ablation for Ventricular Tachycardia Among patients with unprotected left main coronary artery disease, intravascular ultrasonography–guided PCI did not result in a lower risk of ischemic events or death than angiography-guided PCI. https://www.nejm.org/doi/full/10.1056/NEJMoa2600440?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600440 Luca Testa, Jose Maria De la Torre Hernandez, Giovanni Luigi De Maria, Daniel A. Jones, Pablo Piñon-Esteban, Gianluca Campo, Bruno Garcia del Blanco, Manuel Pan, Tamara Garcia-Camarero, Gennaro Sardella, Peter O’Kane, John P. Greenwood, Flavio L. Ribichini, Irene Pescetelli, Alfonso Ielasi, Iñigo Lozano, James Cockburn, Jacopo A. Oreglia, Azfar G. Zaman, Francesco Bedogni, Wietze Lindeboom, Jan G.P. Tijssen, Ernest Spitzer, Adrian P. Banning, the OPTIMAL Investigators* 2026-03-30 IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease Among patients with infrainguinal artery disease who were undergoing angioplasty, the risk of major adverse limb events at 1 year was lower with sirolimus-coated balloons than with uncoated balloons, and mortality was similar. https://www.nejm.org/doi/full/10.1056/NEJMoa2600360?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600360 Stefano Barco, Rolf P. Engelberger, Ulrike Held, Riccardo M. Fumagalli, Alexandru Grigorean, Daniel Hayoz, Mario Münger, Tim Sebastian, Roman Stadler, Davide Voci, Simon Wolf, Frédéric Baumann, Tobias Tritschler, Conrad von Stempel, Daniel Périard, Nils Kucher, the SirPAD Investigators* 2026-03-30 Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease In a randomized trial involving patients undergoing complex high-risk PCI, the risk of target-vessel failure (a composite outcome) was not lower with intravascular ultrasound guidance than with angiography guidance. https://www.nejm.org/doi/full/10.1056/NEJMoa2601521?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601521 Roberto Diletti, Joost Daemen, Benjamin Faurie, Marco Barbierato, Didier Tchétché, Thomas Hovasse, Koen Teeuwen, Jin M. Cheng, Martin Landt, Gianluca Campo, Johan Bennett, Fernando Alfonso, Kambis Mashayekhi, Raul Moreno, Youssef S. Abdelwahed, Ton Heestermans, Jose M. de la Torre Hernandez, John C. Murphy, Ignacio Amat-Santos, Joseph Dens, Alfonso Franzé, David M. Leistner, Angie Ghattas, James C. Spratt, Adrian P. Banning, Jan G.P. Tijssen, Ernest Spitzer, Nicolas M. Van Mieghem, the IVUS-CHIP Investigators* 2026-03-30 Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI Patients with advanced peripheral artery disease often undergo either surgical or endovascular revascularization for the treatment of lifestyle-limiting claudication or nonhealing lower-limb wounds. Major limitations of endovascular intervention include the high incidence of restenosis and the need for repeat intervention with standard balloon angioplasty. During the past decade, the use... https://www.nejm.org/doi/full/10.1056/NEJMe2602625?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602625 Ehrin J. Armstrong 2026-03-30 Sirolimus-Eluting Technology for the Treatment of Peripheral Artery Disease Treatment of the left main coronary artery with percutaneous coronary intervention (PCI) in the absence of previous surgical revascularization, also referred to as an unprotected left main coronary artery PCI, is one of the riskier tasks that interventional cardiologists are asked to perform. Stent implantation in the left main coronary... https://www.nejm.org/doi/full/10.1056/NEJMe2602959?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602959 Frederick Welt 2026-03-30 Seeing the Left Main Coronary Artery Clearly — Is IVUS Always Necessary? The use of intravascular ultrasound (IVUS) imaging for assessment of the coronary arteries has an almost 40-year history. In an editorial comment on an early ex vivo assessment of the accuracy of IVUS in evaluating human coronary arteries, Yock and Linker1 posed three questions that remain relevant today:... https://www.nejm.org/doi/full/10.1056/NEJMe2603397?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603397 Adnan Kastrati 2026-03-30 IVUS — A Zigzag Path to Success In a randomized trial, FFRangio (fractional flow reserve derived from angiography) was noninferior to pressure-wire–guided assessment in reducing risk among patients with intermediate coronary stenosis. https://www.nejm.org/doi/full/10.1056/NEJMoa2600949?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600949 William F. Fearon, Allen Jeremias, Guy Witberg, Rasha Al-Lamee, David J. Cohen, Amir Kaki, Rahul P. Sharma, Robert W. Yeh, Bassem M. Chehab, Michael C. Kim, Hiromasa Otake, Rajiv Tayal, Hitoshi Matsuo, Margaret McEntegart, Ankitkumar K. Patel, Yader Sandoval, Karim M. Al-Azizi, Kazuhiro Dan, Louai Razzouk, Stephane Fournier, Alexandra Popma, Jeffrey J. Popma, Duzhi Zhao, Bjorn Redfors, Mahesh V. Madhavan, Ran Kornowski, Martin B. Leon, Ajay J. Kirtane, the ALL-RISE Investigators* 2026-03-29 Angiography-Derived Fractional Flow Reserve to Guide PCI Among patients undergoing complex PCI, elective unloading with a microaxial flow pump did not reduce the risk of major adverse clinical outcomes as compared with standard care. https://www.nejm.org/doi/full/10.1056/NEJMoa2515704?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515704 Divaka Perera, Matthew Ryan, Saad M. Ezad, Sohail Q. Khan, Ian Webb, Peter D. O’Kane, Roshan Weerackody, Matthew Dodd, Matthew Kwok, Lynn Laidlaw, Laura Van Dyck, Benjamin Wrigley, Julian W. Strange, Alan Bagnall, Farzin Fath-Ordoubadi, Vasileios F. Panoulas, Andrew Ladwiniec, John R. Davies, Alexander Chase, Colum G. Owens, Stuart Watkins, Haseeb Rahman, Nilesh Pareek, Krishnaraj Rathod, John Rawlins, Richard Evans, Stephen P. Hoole, Rod H. Stables, Nick Curzen, Tim Clayton, the CHIP-BCIS3 Investigators* 2026-03-29 Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Among patients with intermediate coronary lesions, angiography-guided revascularization was noninferior to pressure-wire–based guidance with respect to death, myocardial infarction, or revascularization. https://www.nejm.org/doi/full/10.1056/NEJMoa2601841?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601841 Joost Daemen, Jari A. van der Eijk, Marco Barbierato, Robert A. Byrne, Paolo Canova, Giovanni L. De Maria, Eric Van Belle, Ignacio Amat-Santos, Antonio Mangieri, Thomas Hovasse, Manel Sabaté, Ronan Margey, Simone Biscaglia, Fernando Rivero, Domenico D’Amario, Youssef S. Abdelwahed, Rohit M. Oemrawsingh, Raul Moreno, James Cockburn, Luca Testa, Ton de Vries, Ulf Landmesser, Adrian P. Banning, Jan G.P. Tijssen, Ernest Spitzer, the FAST III Investigators* 2026-03-29 Angiography-Based Physiology to Guide Coronary Revascularization