The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Cardiology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sat, 02 May 2026 23:55:51 GMT 2026 NEJM Group en-us 1440 This Double Take video reviews pharmacologic and nonpharmacologic interventions for heart failure with preserved ejection fraction. https://www.nejm.org/doi/full/10.1056/NEJMp2516848?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516848 Sanjiv J. Shah, Sadiya Khan, Donald Lloyd-Jones, Neha J. Pagidipati, Caitlan Pawlowski, Kevin Kirk, Lori Hogan, Janice Williams, Jane Leopold 2026-04-30 Double Take: HFpEF Explained — Managing HFpEF in Primary Care A physician offers to help in a medical emergency on a transatlantic flight. Though she faces limits of bureaucracy, equipment, and ultimately biology, she discovers her physicianhood is inescapable. https://www.nejm.org/doi/full/10.1056/NEJMp2511971?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2511971 Elizabeth Rourke 2026-04-30 Shock Not Advised In patients with persistent atrial fibrillation, first-line treatment with pulsed field ablation reduced the recurrence of atrial arrhythmias at 12 months as compared with antiarrhythmic drugs. https://www.nejm.org/doi/full/10.1056/NEJMoa2600929?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600929 Oussama M. Wazni, K.R. Julian Chun, Devi G. Nair, Ante Anic, Mattias Duytschaever, Jonathan Chrispin, Anish Amin, Olujimi A. Ajijola, Douglas N. Gibson, Moussa Mansour, Jonathan P. Piccini, Andrea Natale, Auroa Badin, Joaquin Osca, Jonathan Dukes, Karan Bhalla, Ayman Hussein, Todd Senn, Stanislav Weiner, Nitesh Sood, Antonio Dello Russo, Ashish Sadhu, Jason Meyers, Kevin Trulock, Mark T.K. Tam, David B. DeLurgio, Jean Champagne, Saverio Iacopino, Brian Kwan, Elizabeth M. Albrecht, Sheryl McCammon, Ann C. Garlitski, Brad S. Sutton, Kenneth M. Stein, Jason G. Andrade, the AVANT GUARD Study Investigators* 2026-04-25 Pulsed Field Ablation as Initial Therapy for Persistent Atrial Fibrillation Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2515043?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515043 The Trident Research Group, Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Bazan, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers 2026-04-23 Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage Effective blood-pressure control is the cornerstone of management after intracerebral hemorrhage; it is both the primary determinant of risk and the most vital intervention for reducing the threat of a second vascular event.1 Yet, despite the availability of effective treatments, blood pressure remains poorly controlled in survivors of... https://www.nejm.org/doi/full/10.1056/NEJMe2600995?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2600995 Ayush Batra, Farzaneh Sorond 2026-04-23 Blood-Pressure Control after Intracerebral Hemorrhage — An Unbroken Glass Ceiling This Double Take video reviews heart failure with preserved ejection fraction, its risk factors and causes, and the challenge in establishing the diagnosis. https://www.nejm.org/doi/full/10.1056/NEJMp2516847?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516847 Sadiya Khan, Donald Lloyd-Jones, Neha J. Pagidipati, Sanjiv Shah, Susan Lehrer, Jane Leopold 2026-04-23 Double Take: HFpEF Explained — Prevalence, New Advances, and How to Diagnose Utah recently rolled out a pilot program involving an AI system that autonomously renews certain prescriptions for people with chronic conditions. This program raises important clinical and legal issues. https://www.nejm.org/doi/full/10.1056/NEJMp2601148?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601148 Sara Gerke, Ravi B. Parikh, I. Glenn Cohen 2026-04-23 Utah’s Prescription-Renewal Pilot Program — Autonomous AI Managing Patient Care In a randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month. https://www.nejm.org/doi/full/10.1056/NEJMoa2511478?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2511478 Siyuan Lin, Yuanchen He, Lan He, Yiling Liu, Fangjie Wang, Zhenyu Xiong, Yixiang Lin, Lan Ye, Chen Chu, Feng Wang, Lu Zhao, Yinyin Cao, Yuanzheng Zheng, Qin Huang, Jie Wang, Xuecun Liang, Quming Zhao, Shuna Sun, Yalan Dou, Wennan He, Xiaobi Huang, Jingwei Sun, Xianmei Huang, Yan Li, Yanling Liao, Haitao Lv, Silin Pan, Hua Zhu, Xinjiang An, Xuehua He, Cuifen Zhao, Xiaoyan Liu, Yaofei Hu, Jinhua Piao, Lijun Qin, Xiangyu Dong, Qian Peng, Ce Wang, Shubin Lin, Ping Huang, Rongzhou Wu, Hua Peng, Zipu Li, Duolao Wang, Xiaohui Liu, Weili Yan, Fang Liu, Guoying Huang, the Chinese Kawasaki Disease Collaboration Network* 2026-04-16 Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2513880?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513880 Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh, the OCEANIC-STROKE Investigators* 2026-04-16 Asundexian for Secondary Stroke Prevention Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the absolute risk is low. Transdermal estradiol and micronized progesterone carry lower risk. https://www.nejm.org/doi/full/10.1056/NEJMra2202438?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2202438 Leslie Skeith, Shannon M. Bates 2026-04-16 Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk Despite the implementation of efficacious interventions for secondary prevention, patients with ischemic stroke or transient ischemic attack (TIA) remain at substantial residual risk for short- and long-term recurrent ischemic stroke and coronary events.1,2 Approximately three quarters of ischemic strokes or TIAs are noncardioembolic and may be attributable to... https://www.nejm.org/doi/full/10.1056/NEJMe2601859?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2601859 Marion Boulanger 2026-04-16 Asundexian for Noncardioembolic Ischemic Stroke Kawasaki disease is the most common cause of acquired heart disease in children in the developed world.1 Although Kawasaki disease manifests with acute, transient systemic signs, its long-term morbidity derives from necrotizing vasculitis that predominantly affects the coronary arteries.2,3 The primary goal of therapy during the... https://www.nejm.org/doi/full/10.1056/NEJMe2518759?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518759 Jane C. Burns, Jane W. Newburger 2026-04-16 Glucocorticoids in Kawasaki Disease — Refining Indications and the Science Among patients with moderate or severe PTS, the addition of endovascular therapy to standard care resulted in less severe PTS and better quality of life at 6 months than standard care alone but with a higher risk of bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2519001?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2519001 Suresh Vedantham, Susan R. Kahn, William A. Marston, Ido Weinberg, Akhilesh K. Sista, Elizabeth A. Magnuson, David J. Cohen, Suman M. Wasan, Mahmood K. Razavi, Samuel Z. Goldhaber, Kristen M. Sanfilippo, Anthony J. Comerota, Ezana M. Azene, Cassius Iyad Ochoa Chaar, Daniel A. Leung, K. Pallav Kolli, Sanjeeva P. Kalva, Nassir Rostambeigi, Ajinkya Desai, Kush R. Desai, Alfonso J. Tafur, Bhavraj Khalsa, Elaine Majerus, Borong Wang, Yang Wang, Patricia Nieters, Mary Clare Derfler, Angela Oliver, Cassandra Hardy, Riyaz Bashir, Ronald Winokur, Natalie Weger, Minhaj S. Khaja, Aditya Sharma, Naganathan Mani, Pavan Kavali, Siddhant Thukral, Leslie L. Lake, Kathryn Mikkelsen, Sameer Parpia, the C-TRACT Trial Investigators* 2026-04-13 Endovascular Therapy for Post-Thrombotic Syndrome — A Randomized Trial Post-thrombotic syndrome is the most common chronic complication of deep-vein thrombosis (DVT), affecting 20 to 50% of patients with DVT and causing debilitating symptoms involving the limbs — including pain, swelling, skin changes, and venous ulcers — that substantially reduce quality of life and impose considerable socioeconomic burden.1 ... https://www.nejm.org/doi/full/10.1056/NEJMe2603048?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603048 Ronald Luiz Gomes Flumignan, Luís Carlos Uta Nakano 2026-04-13 Stenting for Post-Thrombotic Syndrome — A Step Forward Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. https://www.nejm.org/doi/full/10.1056/NEJMoa2600283?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600283 Yong-Joon Lee, Seung-Jun Lee, Jin Won Kim, Sang-Hyup Lee, Gwang-Sil Kim, Jae Hyoung Park, Jin-Man Cho, Woong Chol Kang, Hyuck-Jun Yoon, Won Ho Kim, Seung-Jin Lee, Jin Bae Lee, Ji-Yong Jang, Sanghoon Shin, Ik Hyun Park, Sung Uk Kwon, Sunwon Kim, Sung-Jin Hong, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Byeong-Keuk Kim, the Ez-PAVE Investigators* 2026-04-09 Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease Among low-income patients with hypertension, a multifaceted, team-based strategy resulted in a greater reduction in systolic blood pressure than enhanced usual care. https://www.nejm.org/doi/full/10.1056/NEJMoa2504068?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2504068 Katherine T. Mills, Marie Krousel-Wood, Erin M. Peacock, Jing Chen, Farah Allouch, Amy K. Carreras, Siyi Geng, Alecia Cyprian, Gerrelda Davis, Sonja R. Fuqua, Darie Gilliam, Angelique Greer, Tammy Mitchell, Wylea Gray-Winfrey, Shondra Williams, Gary M. Wiltz, Keith L. Winfrey, Hua He, Paul K. Whelton, Jiang He 2026-04-09 Multifaceted Strategies for Hypertension Control in Low-Income Patients In 2022, more than 130,000 deaths in the United States were primarily attributable to high blood pressure and were largely preventable; this number represents a near doubling since 2012.1 Despite the availability of multiple effective, safe, and inexpensive therapies for lowering blood pressure, fewer than half of U.S.... https://www.nejm.org/doi/full/10.1056/NEJMe2518341?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518341 Sadiya S. Khan, Mark D. Huffman 2026-04-09 Systems-Based Success for Hypertension A 70-year-old woman presented with a racing heart, fatigue, dyspnea, and leg edema. One month earlier, percutaneous catheter ablation for atrial fibrillation had been performed. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513542?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513542 Thomas K. Varghese Jr., Eliza D. Hompe, Shaan S. Khurshid, Jo-Anne O. Shepard, Eriberto Michel, Uma M. Sachdeva 2026-04-09 Case 10-2026: A 70-Year-Old Woman with a Racing Heart, Fatigue, and Dyspnea In patients with atherosclerotic cardiovascular disease, lowering lipid levels is critical for reducing the risk of recurrent cardiovascular disease. International guidelines endorse the targeting of a low-density lipoprotein (LDL) cholesterol level of less than 55 mg per deciliter for secondary prevention of atherosclerotic cardiovascular disease in patients at high risk... https://www.nejm.org/doi/full/10.1056/NEJMe2601725?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2601725 Jeffrey L. Probstfield, Kelley R.H. Branch 2026-04-09 Paving the Road toward Targeted Lipid Lowering Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. https://www.nejm.org/doi/full/10.1056/NEJMoa2513310?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513310 Ulf Landmesser, Carsten Skurk, Paulus Kirchhof, Thorsten Lewalter, Johannes Hartung, Andi Rroku, Burkert Pieske, Johannes Brachmann, Ibrahim Akin, Claudius Jacobshagen, Benjamin Meder, Andreas Zeiher, Stefan D. Anker, Holger Thiele, Stefan Blankenberg, Steffen Massberg, Heribert Schunkert, Norbert Frey, Alexander Joost, Martin Bergmann, Ralph Stephan von Bardeleben, Tim Friede, Marius Placzek, Anna Suling, Karl Georg Haeusler, Matthias Endres, Karl Wegscheider, Leif-Hendrik Boldt, Ingo Eitel, the CLOSURE-AF Trial Investigators* 2026-04-02 Left Atrial Appendage Closure or Medical Therapy in Atrial Fibrillation