The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Fri, 12 Jun 2026 23:45:31 GMT 2026 NEJM Group en-us 1440 Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors. https://www.nejm.org/doi/full/10.1056/NEJMoa2516225?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516225 The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network 2026-06-11 Vasopressors or Fluids in Early Septic Shock An 11-year-old girl presented with a 1-month history of right thigh pain that worsened at night. Radiographs of the knee revealed a metaphyseal osteoblastic lesion with a sunburst appearance. https://www.nejm.org/doi/full/10.1056/NEJMicm2600191?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2600191 Hsueh-Min Kuo, Wei-Ming Chen 2026-06-11 Osteosarcoma We now know that humans are more than 99.9% genetically alike. So why does medicine still link certain diseases to race? And what do genetics actually tell us about race, ancestry, and disease? https://www.nejm.org/doi/full/10.1056/NEJMp2601980?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601980 2026-06-11 Intention to Treat — Season 2: The Race Equation: The Myth of Race and Genetics — ITT Episode 2.6 A 14-year-old girl was admitted to the hospital because of hypertension and headache. She had hypokalemia, an elevated blood level of C-reactive protein, and an elevated erythrocyte sedimentation rate. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866 Rachel R. Osborn, Jonathan S. Hausmann, Weizhen Tan, Evan J. Zucker 2026-06-11 Case 16-2026: A 14-Year-Old Girl with Hypertension Despite recognition that racial and ethnic categories are poor proxies for genetic diversity, race is still used to guide pharmaceutical use, posing risks of ineffectively low or dangerously high dosing. https://www.nejm.org/doi/full/10.1056/NEJMp2516090?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516090 Harsimar K. Ahuja, David S. Jones, Winfred W. Williams 2026-06-11 Prescription without Precision — Dangers of Dosing on the Basis of Race as Biology Clinicians might dismiss excessive gambling as a behavior outside the scope of medical care. But screening for gambling disorder and other psychiatric conditions could help mitigate related harms. https://www.nejm.org/doi/full/10.1056/NEJMp2517679?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2517679 Debi A. LaPlante, Heather M. Gray 2026-06-11 Detecting Gambling-Related Problems — An Opportunity to Reduce Suicidality Having inherited a strong sense of professionalism from her mother and female physician mentors, a trainee finds the realities of juggling motherhood and medicine more difficult than she expected. https://www.nejm.org/doi/full/10.1056/NEJMp2513897?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2513897 Sarah Calvert 2026-06-11 Carrier A 58-year-old woman with diabetes complicated by diabetic retinopathy presented for an annual eye examination. Stereo fundus photographs showed neovascularization of the disk extending out from the retinal plane. https://www.nejm.org/doi/full/10.1056/NEJMicm2601416?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2601416 Ella J. Gehrke, Ian C. Han 2026-06-11 Neovascularization of the Disk in Proliferative Diabetic Retinopathy Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy. https://www.nejm.org/doi/full/10.1056/NEJMoa2513814?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513814 The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group 2026-06-10 Conservative Oxygen for Unresponsive Patients after Cardiac Arrest Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm. https://www.nejm.org/doi/full/10.1056/NEJMoa2603406?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2603406 Bronwen Connolly, Naomi Dickson, Christina Campbell, Judy M. Bradley, Brenda O’Neill, Ashley Agus, Mike Barker, Jeremy S. Bewley, Bronagh Blackwood, Mark Borthwick, Luigi Camporota, Marc Chikhani, Mike Clarke, Paul Dark, Lisa Higgins, Penelope Lambert, Thomas Lunn, Cliona McDowell, Margaret McFarland, Una McShane, Reena Mehta, Ben Messer, Ben Morton, Nehal Patel, Gavin D. Perkins, Deborah Rowley, Murali Shyamsundar, Jonathan A. Silversides, Gordon Sturmey, John Warburton, Barry Williams, Ranjit Lall, Daniel F. McAuley, the MARCH Trial Investigators* 2026-06-10 Carbocisteine or Hypertonic Saline for Acute Respiratory Failure In a cluster-randomized trial involving patients having major noncardiac surgery, tranexamic acid reduced the need for red-cell transfusion during hospitalization and was noninferior to placebo for venous thromboembolism within 90 days. https://www.nejm.org/doi/full/10.1056/NEJMoa2515820?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515820 Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, Salmaan Kanji, Peter Greenstreet, Meghan Andrews, Sinziana Avramescu, Hema S. Bagry, Robert Balshaw, Jayesh Daya, Kaitlin Duncan, Christopher C. Harle, Eric Jacobsohn, Tina Kerelska, Marshall Pitz, Paul Komenda, Sarah McIsaac, Tim Ramsay, Tarit Saha, Alan Tinmouth, Angela Recio, Daniel Szoke, Marshall Tenenbein, Sarah Slagerman, Dayna Solvason, Robert Talarico, Dean A. Fergusson, Ryan Zarychanski 2026-06-10 Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific evidence on the overall safety, efficacy,... https://www.nejm.org/doi/full/10.1056/NEJMe2603105?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603105 Michael F. Murphy, Ian Roberts 2026-06-10 TRACTION for Greater Surgical Use of Tranexamic Acid In a phase 3 trial involving adults with obesity but without diabetes, the glucagon receptor–GLP-1 receptor dual agonist survodutide led to significantly greater reductions in body weight than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2600751?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600751 Carel W. le Roux, Sean Wharton, Elena Startseva, Isabel M. Kloer, Samina Ajaz Hussain, Anna Unseld, Biykem Bozkurt, Jamy D. Ard, Harold E. Bays, Pawel Bogdański, Elif I. Ekinci, Ania M. Jastreboff, Linong Ji, Wataru Ogawa, Sue D. Pedersen, Kirsi H. Pietiläinen, Naveed Sattar, Jochen Seufert, Kaj Stenlöf, André P. van Beek, Roman Vangoitsenhoven, Martina Brueckmann, Ramy Younes, Lee M. Kaplan, the SYNCHRONIZE-1 Investigators* 2026-06-07 Survodutide Once Weekly for the Treatment of Adults with Obesity In this 104-week trial involving patients with primary membranous nephropathy, the type II anti-CD20 antibody obinutuzumab was superior to the calcineurin inhibitor tacrolimus in inducing complete remission. https://www.nejm.org/doi/full/10.1056/NEJMoa2602678?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2602678 Fernando C. Fervenza, Fan Fan Hou, Chuan-Ming Hao, Gianna M. Kirsztajn, Loreto Gesualdo, Tomasz Hryszko, Antonio Pisani, Dario Roccatello, Andrew S. Bomback, Julie Rae, Farima Barmaki, Eriola Berisha, Thomas Schindler, Theodore A. Omachi, Jay P. Garg, Ana Malvar, the MAJESTY Trial Investigators* 2026-06-05 Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy In a multicenter trial involving patients with acute hypoxemic respiratory failure, 28-day mortality with high-flow oxygen was not significantly different from that with standard oxygen. https://www.nejm.org/doi/full/10.1056/NEJMoa2516087?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516087 Jean-Pierre Frat, Jean-Pierre Quenot, Christophe Guitton, Rémi Coudroy, Arnaud Gacouin, Julio Badie, Alexandre Demoule, Damien Contou, Guillaume Carteaux, Stephan Ehrmann, Fabien Jarousseau, Nicholas Sedillot, Jean-Philippe Rigaud, Jean Reignier, François Beloncle, Anne-Florence Dureau, Alexis Ferré, Cédric Daubin, Anna Bourreau, Agathe Delbove, Gaël Pradel, Abdelhamid Fatah, Gwenhael Colin, Guillaume Deniel, Olivier Lamouret, Béatrice La Combe, Gwénaël Prat, Louis-Marie Galerneau, Gaël Bourdin, Gautier Julien, Anaïs Curtiaud, Mélanie Saint-Léger, Emanuele Turbil, Faustine Reynaud, Louis Chamblet, Stéphanie Ragot, Arnaud W. Thille, the SOHO Trial Group and the REVA Network* 2026-06-04 High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure Vaccine hesitancy is often driven by safety concerns. Clinician recommendations, presumptive communication, and empathy improve uptake; maintaining trust supports future acceptance and community protection. https://www.nejm.org/doi/full/10.1056/NEJMcp2516616?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2516616 Sean T. O’Leary, Margie Danchin 2026-06-04 Childhood Vaccine Hesitancy Acute hypoxemic respiratory failure remains one of the most common conditions encountered in the intensive care unit (ICU).1 During the past decade, high-flow nasal oxygen has moved from physiological curiosity to frontline therapy.2 Early enthusiasm followed the publication of the results of the 2015 FLORALI trial, https://www.nejm.org/doi/full/10.1056/NEJMe2602037?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602037 Ary Serpa Neto 2026-06-04 Rethinking High-Flow Oxygen in Acute Hypoxemic Respiratory Failure The Indian Health Pathway at the University of Washington School of Medicine aims to help bridge the health gap between Indigenous Americans and the broader U.S. population. https://www.nejm.org/doi/full/10.1056/NEJMp2605243?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605243 Joseph Nelson, Millie Kennedy, Jason F. Deen 2026-06-04 Efforts toward Equity: Advancing Indigenous Health Equity in Medical School Curricula A 56-year-old woman presented with a 3-week history of leg swelling. On physical examination, pitting edema in both legs and a milky appearance to the urine were observed. https://www.nejm.org/doi/full/10.1056/NEJMicm2516914?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2516914 Carles Cañameras, Jaume Sampere 2026-06-04 Chyluria from a Lymphatic–Urinary Fistula This feature about the interview process for residency applicants offers a case vignette accompanied by two essays, one recommending continuing virtual-only residency interviews and the other supporting a return to in-person residency interviews. https://www.nejm.org/doi/full/10.1056/NEJMclde2508421?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMclde2508421 Sarah Gorey, Cheryl O’Malley, Ciara Voy, Anne Richardson, Jennifer Corbelli 2026-06-04 Virtual-Only or In-Person Interviews for Residency Applicants