The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Fri, 09 Oct 2026 07:11:08 GMT 2026 NEJM Group en-us 1440 In patients with severe tricuspid regurgitation and heart failure, transcatheter tricuspid-valve repair plus medical therapy was superior to medical therapy alone in reducing hospitalizations for heart failure and deaths. https://www.nejm.org/doi/full/10.1056/NEJMoa2606934?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2606934 Jörg Hausleiter, Thomas J. Stocker, Tobias Geisler, Philipp Lurz, Wolfgang Rottbauer, Edith Lubos, Niklas Schofer, Christian Frerker, Johanne Frank, Holger Thiele, Rico Osteresch, Volker Rudolph, Alexander Lauten, Erion Xhepa, Jürgen Rothe, Tienush Rassaf, Stephan Baldus, Georg Nickenig, David M. Leistner, Eike Tigges, Victoria Kehl, Mirjam Kessler, Tobias Kister, Tobias Ruf, Muhammed Gerçek, Meinrad Gawaz, Derk Frank, Ingo Eitel, Ralph Stephan von Bardeleben, Daniel Kalbacher, Osama Soliman, Michael Näbauer, Steffen Massberg, the TRIC-I-HF-DZHK24 Investigators* 2026-10-08 Tricuspid-Valve Intervention in Heart Failure In a trial of a blood-based multicancer early-detection test added to usual care, the incidence of stage III or IV cancer after three rounds of screening did not differ significantly from that with usual care alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2505723?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2505723 Peter Sasieni, Peter Johnson, Thomas Round, Jane Warwick, Helen Jones, Saoirse Dolly, Lennard Lee, Yujin Lee, Harpal Kumar, Wei Liang, Rebecca Smittenaar, Richard D. Neal, Charles Swanton 2026-10-08 Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors. https://www.nejm.org/doi/full/10.1056/NEJMoa2516225?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516225 The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network 2026-10-08 Vasopressors or Fluids in Early Septic Shock Biomedical research encompasses diverse scientific activities with distinct sources of variation, attainable precision, and standards of inference, as this functional typology of reproducibility clarifies. https://www.nejm.org/doi/full/10.1056/NEJMms2607020?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMms2607020 Harvey V. Fineberg 2026-10-08 Reproducibility in Biomedical Science — From Repetition to Corroboration A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple. https://www.nejm.org/doi/full/10.1056/NEJMicm2605910?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2605910 Yangbin Wang, Chun-Fang Guo 2026-10-08 Syphilitic Chancre on the Nipple When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread. https://www.nejm.org/doi/full/10.1056/NEJMp2608136?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2608136 Celestin Mutuyimana, Clare Killikelly 2026-10-08 Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in... https://www.nejm.org/doi/full/10.1056/NEJMe2609170?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609170 Theodore J. Iwashyna 2026-10-08 More Than One Way to Save a Life in Septic Shock A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603182?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603182 Ezra M. Cohen, Shohei Fujita, Daniel R. Brown, Vanda F. Torous 2026-10-08 Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia The diagnosis of cancer at earlier stages is generally associated with improved survival. Detecting circulating tumor–derived cell-free DNA (cfDNA) is an established method of monitoring the response to therapy for many cancer types, particularly hematopoietic and metastatic cancers — which leads to the question of whether screening for cfDNA in... https://www.nejm.org/doi/full/10.1056/NEJMe2611312?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2611312 David J. Hunter 2026-10-08 A Step in the Search for the Elusive Holy Grail of Early Detection of Cancer A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries. https://www.nejm.org/doi/full/10.1056/NEJMicm2607595?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2607595 Hsin-Yu Chen, Chi-Nien Chen 2026-10-08 Menkes Disease The care of patients with valvular heart disease has been revolutionized by three key advances in the field: technological innovation of transcatheter therapies combined with the audacity to try new procedures; a heart team that includes interventional cardiologists, cardiac surgeons, imaging specialists, and, when needed, heart-failure cardiologists working in partnership... https://www.nejm.org/doi/full/10.1056/NEJMe2611648?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2611648 Manesh R. Patel 2026-10-08 Transcatheter Tricuspid-Valve Intervention for Severe Tricuspid Regurgitation As access to medical knowledge is democratized, the specialist’s position atop the medical hierarchy grows shaky. With integration and synthesis more precious than ever, the generalist deserves reappraisal. https://www.nejm.org/doi/full/10.1056/NEJMp2603758?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603758 Dean Ariel 2026-10-08 A Guide for the Perplexed Physician In five pediatric heart transplantations, a rapid-recovery technique involving oxygenated preservation enabled the use of donated hearts without reanimation. All recipients had normal biventricular function by day 7. https://www.nejm.org/doi/full/10.1056/NEJMc2607437?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2607437 Aaron M. Williams, Swaroop Bommareddi, Kevin C. McGann, Awab Ahmad, John Trahanas, Brian Lima, Tammy Ruth, David W. Bearl, Rachel E. Harris, Ryan D. Byrne, Caroline West, A. Joey Lepore, Phyllis Aycock, Nicole Michaud, Sonya Burrell, Susana A. Stripling, Amir T. Dereshgi, Garrett Coyan, David Bichell, Amanpreet Kalsi, Amy M. Babb, Michael Kuntz, Jessica Clark, Shelley Scholl, Matthew Bacchetta, Ashish S. Shah, Yishay Orr, Carlos M. Mery, Ziv Beckerman 2026-10-08 Pediatric Heart Transplantation with Donation after Circulatory Death In this phase 3, double-blind, placebo-controlled trial involving adults with obesity and type 2 diabetes, the investigational glucagon receptor–GLP-1 receptor dual agonist survodutide led to significant weight reduction. https://www.nejm.org/doi/full/10.1056/NEJMoa2607219?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607219 Sean Wharton, Carel W. le Roux, Elena Startseva, Isabel M. Kloer, Ahmad Alhussein, Samina Ajaz Hussain, Anna Unseld, Biykem Bozkurt, Jamy D. Ard, Harold E. Bays, Paweł Bogdański, Jawad H. Butt, Elif I. Ekinci, Ania M. Jastreboff, Linong Ji, Morten Schou, Francisco J. Tinahones, Alexander D. Kokkinos, Béla Merkely, Wataru Ogawa, Sue D. Pedersen, Kirsi H. Pietiläinen, Dean Quinn, Naveed Sattar, Jochen Seufert, Kaj Stenlöf, André P. van Beek, Roman Vangoitsenhoven, Martina Brueckmann, Ramy Younes, Lee M. Kaplan, the SYNCHRONIZE-2 Investigators* 2026-10-01 Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival. https://www.nejm.org/doi/full/10.1056/NEJMoa2607314?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607314 Sophia Zoungas, Rory Wolfe, Chris Moran, Stephen J. Nicholls, Geoffrey C. Cloud, Christopher M. Reid, Andrew M. Τonkin, Lawrence Beilin, Anthony S. Wierzbicki, Trevor T.-J. Chong, Jonathan C. Broder, Andrea J. Curtis, Zachary Flanagan, Ingrid Hopper, Joanne Ryan, Simone Spark, John J. McNeil, Mark R. Nelson, the STAREE Investigators 2026-10-01 Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2601337?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601337 Emanuel Della-Torre, Matthew C. Baker, Wen Zhang, Cory A. Perugino, Guy Katz, Yoshiya Tanaka, Arezou Khosroshahi, Alexander Kleger, Nicolas Schleinitz, Fernando Martinez-Valle, Hendrik Schulze-Koops, Shingo Nakayamada, Vinciane Rebours, Kazuichi Okazaki, Lingli Dong, Mollie Carruthers, Luke Y.C. Chen, Luca Frulloni, Alireza Meysami, Hiroki Takahashi, Mitsuhiro Kawano, Yanying Liu, Takako Saeki, Mikael Ebbo, Tobias Alexander, Andrés González García, Omer Karadag, Maria Maślińska, Shauna M. Quinn, Allen Poma, Audrey Wells, Thomas J. Greene, John H. Stone, Emma L. Culver, the INDIGO Trial Investigators* 2026-10-01 Obexelimab for the Treatment of IgG4-Related Disease This Double Take video describes the burden of global tobacco use and examines evidence-based tobacco-cessation strategies, including their implementation and associated challenges in India and Vietnam. https://www.nejm.org/doi/full/10.1056/NEJMp2414537?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2414537 Pratima Murthy, Hoang Van Minh, Donna Shelley, Nancy A. Rigotti, Kamran Siddiqi, Emily Ling, Darren Taichman 2026-10-01 Double Take: Tobacco-Cessation Treatment for Global Impact When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self. https://www.nejm.org/doi/full/10.1056/NEJMp2603393?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603393 Michael A. Incze, Laura Stolebarger 2026-10-01 The Mayor A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness. https://www.nejm.org/doi/full/10.1056/NEJMcps2600385?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcps2600385 Roni Eichel, Gabriel S. Breuer, Eyal Ben Dori, Merav Weil, Eli Ben-Chetrit 2026-10-01 An Echo Unheard For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of age... https://www.nejm.org/doi/full/10.1056/NEJMe2611127?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2611127 Martin Bødtker Mortensen 2026-10-01 Statins in Older Adults — Evidence at Last