The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Fri, 11 Sep 2026 04:06:23 GMT 2026 NEJM Group en-us 1440 Among patients with ST-segment elevation myocardial infarction and multivessel disease, physiology-guided angiography led to a lower risk of major cardiovascular events than conventional angiography-guided treatment. https://www.nejm.org/doi/full/10.1056/NEJMoa2605373?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2605373 Simone Biscaglia, Andrea Erriquez, Iginio Colaiori, Abdul Hakeem, Francesca Mantovani, Mila Menozzi, Marco Barbierato, Manfredi Arioti, Giulia Bugani, Roberto Scarsini, Domenico D’Amario, Luca Donazzan, Alberto Polimeni, Massimo Giordan, Giorgio Benatti, Gabriele Venturi, Marco Ruozzi, Francesco Moretti, Alberto Monello, Elisabetta Moscarella, Francesco Versaci, Jehangir Ali Shah, Vincenzo Guiducci, Caterina Cavazza, Francesco Gallo, Andrea Rubboli, Marco Borgi, Ahsan Ali Lakho, Alessandro Capecchi, Valerio Lanzilotti, Filippo Ottani, Gianni Casella, Antonio Maria Leone, Matteo Tebaldi, Rita Pavasini, Raffaele Piccolo, Jacopo Farina, Donato Martella, Gianluca Campo, the AIR-STEMI Trial Investigators* 2026-09-10 Complete Revascularization Guided by Functional Coronary Angiography in STEMI Severe acquired methemoglobinemia was identified in 82 migrants disembarking in Sicily, 74 of whom were treated with methylene blue. Dermal absorption of N-methylaniline was identified as the likely cause. https://www.nejm.org/doi/full/10.1056/NEJMoa2606487?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2606487 Lucia Bernasconi, Davide Lonati, Alessandra Teresi, Francesco D’Arca, Nicolò Ricca, Daniele Merli, Martina Pes, Antonella Rotolo, Elena Grignani, Cristina Agozzino, Cristina Carolina Benussi, Benedetta Brolli, Eleonora Buscaglia, Monica Carnovale, Arianna Centonze, Massimo Ciotta, Francesco Di Lascio, Gerlando Fiorica, Tommaso Frigerio, Fabio Genco, Agostino Massimo Geraci, Giovanni Ippati, Vincenzo Mazzarese, Valentina Maria Negrini, Marco Palmeri, Valeria Margherita Petrolini, Francesco Petrusa, Elisa Roda, Giulia Scaravaggi, Azzurra Schicchi, Sara Scotto, Francesca Zaffino, Carlo Alessandro Locatelli 2026-09-10 Outbreak of Severe Methemoglobinemia during Maritime Migration In this 104-week trial involving patients with primary membranous nephropathy, the type II anti-CD20 antibody obinutuzumab was superior to the calcineurin inhibitor tacrolimus in inducing complete remission. https://www.nejm.org/doi/full/10.1056/NEJMoa2602678?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2602678 Fernando C. Fervenza, Fan Fan Hou, Chuan-Ming Hao, Gianna M. Kirsztajn, Loreto Gesualdo, Tomasz Hryszko, Antonio Pisani, Dario Roccatello, Andrew S. Bomback, Julie Rae, Farima Barmaki, Eriola Berisha, Thomas Schindler, Theodore A. Omachi, Jay P. Garg, Ana Malvar, the MAJESTY Trial Investigators* 2026-09-10 Obinutuzumab or Tacrolimus in Primary Membranous Nephropathy In May 2026, two members of the U.S. Preventive Services Task Force were fired. Vigilance will be necessary to ensure that the panel continues to adhere to rigorous scientific methods. https://www.nejm.org/doi/full/10.1056/NEJMp2607441?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607441 Elizabeth Kaplan, Carmel Shachar 2026-09-10 The Future of the USPSTF and Evidence-Based Recommendations During Operation Metro Surge in Minneapolis, volunteer health care professionals quickly improvised a new system, often without institutional authorization, to continue to care for terrified patients. https://www.nejm.org/doi/full/10.1056/NEJMp2607981?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607981 Munira Maalimisaq, Jennifer Needle-Suarez 2026-09-10 When Fear Became the Barrier to Care — Lessons of a Clinical Rapid Response during Operation Metro Surge A dying patient in a state psychiatric hospital has no access to a DNR order that would make the process as peaceful as possible — as the notorious Bedlam casts a shadow over mental health care to this day. https://www.nejm.org/doi/full/10.1056/NEJMp2600529?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600529 Richard Elledge 2026-09-10 The Long Shadow of Bedlam Throughout U.S. health care settings, patients with a preferred language other than English frequently receive oral interpretation services but English-only written instructions. https://www.nejm.org/doi/full/10.1056/NEJMp2603777?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603777 Melanie F. Molina, Mateo C. Rutherford, Elaine C. Khoong 2026-09-10 AI-Based Translation of Discharge Instructions — Aligning Policy with Practice A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517855?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517855 Jacqueline T. Chu, Robert G. Rasmussen, Jacquelyn M. Nestor, Mack Y. Su 2026-09-10 Case 25-2026: A 65-Year-Old Man with Fever and Rash Membranous nephropathy, the leading cause of nephrotic syndrome in adults, is generally diagnosed through a kidney biopsy in patients presenting with heavy proteinuria, hypoalbuminemia, and edema. Its diagnostic hallmarks include subepithelial immune-complex deposition along the outer aspect of the glomerular basement membrane, which leads to diffuse capillary-wall thickening and a... https://www.nejm.org/doi/full/10.1056/NEJMe2609719?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609719 María José Soler 2026-09-10 A Step Forward — Obinutuzumab for Membranous Nephropathy A 46-year-old man with cirrhosis presented with a 1-week history of left flank pain. Physical examination was notable for a large ecchymosis on the left flank that was tender to palpation. https://www.nejm.org/doi/full/10.1056/NEJMicm2605791?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2605791 Kan-Ru Li, Chien Hao Lin 2026-09-10 Grey Turner’s Sign A 36-year-old man presented with a 1-week history of asymptomatic anisocoria. On examination, the right pupil was dilated and constricted minimally to light and the left pupil constricted briskly to light (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2606883?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2606883 Aaron Donnelly, Richard Farnan 2026-09-10 Adie Tonic Pupil In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common. https://www.nejm.org/doi/full/10.1056/NEJMoa2601598?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601598 Yves Dauvilliers, Emmanuel Mignot, Jakub Antczak, Isabelle Arnulf, Lucie Barateau, Erik Buntinx, Bruce Corser, Alex Iranzo, Ramin Khatami, Gert Jan Lammers, Katharina Lederer, Kristian Bernhard Nilsen, Fabio Pizza, Markus H. Schmidt, Sheila Sivam, Oliver Sum-Ping, Mitsutaka Taniguchi, Shuqin Zhan, Anson Abraham, Alice Cai, Yeting Du, Mark R. Etherton, Helene Faessel, Samuel Hsiao, Harisha Kadali, Elena Koundourakis, Melissa Naylor, Rachel Neuwirth, Tina Olsson, Raquel Rogers, Sarah Sheikh, Shinichiro Tanaka, Philipp von Rosenstiel, Christian von Hehn, Yaming Hang, Baiyun Yao, Rafael del Rio Villegas, Giuseppe Plazzi 2026-09-09 Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type 1... https://www.nejm.org/doi/full/10.1056/NEJMe2607491?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2607491 Lynn Marie Trotti 2026-09-09 Targeted Treatment for Narcolepsy Type 1 In two replicate phase 3 trials involving patients with COPD who were receiving inhaled maintenance therapy, add-on tozorakimab resulted in a lower rate of moderate or severe exacerbations than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2606998?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2606998 Frank C. Sciurba, Henrik Watz, Arnaud Bourdin, Wim Janssens, Fernando J. Martinez, Jinping Zheng, Maarten van den Berge, Matteo Bonini, MeiLan K. Han, Dave Singh, Gerard J. Criner, Christopher E. Brightling, Alberto Papi, Surya P. Bhatt, Martin Jenkins, Marta Mikosz, Piotr Chołbiński, Monika Ziemiecka, Magnus Löfdahl, Deepa Arya, Madhavi Yadavalli, Bryan H. Brodek, Malin Fagerås, Samuel Bardsley, Neil Martin, Rajesh Patel, Ioannis Psallidas, the OBERON and TITANIA Trial Investigators* 2026-09-08 Tozorakimab to Prevent COPD Exacerbations In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-09-03 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock This review summarizes the management of pulmonary nodules, with an emphasis on nodule type, imaging follow-up, cancer risk, and strategies to balance timely diagnosis with avoidance of unnecessary procedures. https://www.nejm.org/doi/full/10.1056/NEJMcp2515063?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2515063 Matthew E.J. Callister, Gerard A. Silvestri 2026-09-03 Pulmonary Nodules A 46-year-old man with CKD presented with a 2-year history of painless shortening and rounding of the fingertips. Radiographs of the hands showed resorption of the terminal tufts of all the distal phalanges. https://www.nejm.org/doi/full/10.1056/NEJMicm2605116?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2605116 Nawarat Pengpong, Thiti Snabboon 2026-09-03 Acro-Osteolysis A 33-year-old man with systemic lupus erythematosus presented with pruritic, burning plaques that evolved into urticarial lesions. Skin biopsy revealed papillary dermal edema, intravascular neutrophils, and C3 deposition. https://www.nejm.org/doi/full/10.1056/NEJMicm2602968?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2602968 Arjun Mahajan, Evan W. Piette 2026-09-03 Urticarial Vasculitis Achondroplasia, the most common skeletal dysplasia, is characterized by impaired longitudinal growth resulting in disproportionate short stature as well as craniofacial abnormalities, spinal stenosis, and increased mortality during infancy from cervicomedullary compression. This condition is caused by mutations in the gene encoding fibroblast growth factor receptor 3 (FGFR3) ,... https://www.nejm.org/doi/full/10.1056/NEJMe2609749?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609749 Isidro B. Salusky, Harald Jüppner 2026-09-03 Infigratinib in Achondroplasia — A Potentially Giant Step Forward In states with abortion bans, clinicians and hospitals should reduce harm by maximizing care to the extent legally possible, thereby recentering medical expertise and commitment to patient-centered care. https://www.nejm.org/doi/full/10.1056/NEJMp2603470?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603470 Rachel Jensen, Elise Boos, Ghazaleh Moayedi, Nisha Verma 2026-09-03 Maximizing Legal Care under Bans on Abortion Provision — A Framework for Reclaiming Agency