The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Tue, 28 Apr 2026 21:26:28 GMT 2026 NEJM Group en-us 1440 A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney biopsy was performed. https://www.nejm.org/doi/full/10.1056/NEJMicm2513605?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2513605 Noriaki Kawano, Ikuo Kikuchi 2026-04-25 Membranoproliferative Glomerulonephritis Due to Cryoglobulinemia A physician offers to help in a medical emergency on a transatlantic flight. Though she faces limits of bureaucracy, equipment, and ultimately biology, she discovers her physicianhood is inescapable. https://www.nejm.org/doi/full/10.1056/NEJMp2511971?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2511971 Elizabeth Rourke 2026-04-25 Shock Not Advised In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-04-24 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2515043?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515043 The Trident Research Group, Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Bazan, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers 2026-04-23 Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage In this randomized trial involving critically ill patients undergoing intubation in EDs or ICUs, the use of ketamine for the induction of anesthesia did not lead to significantly lower in-hospital mortality than etomidate. https://www.nejm.org/doi/full/10.1056/NEJMoa2511420?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2511420 Jonathan D. Casey, Kevin P. Seitz, Brian E. Driver, Kevin W. Gibbs, Adit A. Ginde, Stacy A. Trent, Derek W. Russell, Amelia L. Muhs, Matthew E. Prekker, John P. Gaillard, Daniel Resnick-Ault, L. Jane Stewart, Micah R. Whitson, Stephanie C. DeMasi, Aaron E. Robinson, Jessica A. Palakshappa, Neil R. Aggarwal, Jason C. Brainard, David J. Douin, Tanya K. Marvi, Benjamin K. Scott, Sarah M. Alber, Carolynn Lyle, Sheetal Gandotra, Graham W. Van Schaik, Aaron J. Lacy, Kristen C. Sherlin, Heidi L. Erickson, J. Maycee Cain, Brianne Redman, Logan L. Beach, Barbara Gould, Jasmine McIntosh, Ariel A. Lewis, Bradley D. Lloyd, Tiffany L. Israel, Brant Imhoff, Li Wang, Alexandra B. Spicer, Matthew M. Churpek, Todd W. Rice, Wesley H. Self, Jin H. Han, Matthew W. Semler, the RSI Investigators and the Pragmatic Critical Care Research Group* 2026-04-23 Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults Spinal epidural abscess is an infection in the epidural space commonly caused by Staphylococcus aureus. Symptoms include back pain, neck pain, fever, and neurologic symptoms. Prompt evaluation is important. https://www.nejm.org/doi/full/10.1056/NEJMra2412728?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2412728 Aaron J. Tande, Bradford L. Currier, Douglas R. Osmon 2026-04-23 Spinal Epidural Abscess A 74-year-old man presented with a painful laceration on his leg that he had sustained 3 days earlier in waters off the Gulf Coast of Florida. Ecchymosis, swelling, and crepitus were observed in the lower leg. https://www.nejm.org/doi/full/10.1056/NEJMicm2600207?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2600207 Natalie Rosseau, Norman L. Beatty 2026-04-23 Vibrio vulnificus Necrotizing Soft-Tissue Infection Jack, a retired teacher whose 91 years hadn’t been easy, wanted to leave the hospital forever. With a hospice nurse who was Polish like his cherished grandmother, he could finally take comfort in his care. https://www.nejm.org/doi/full/10.1056/NEJMp2510702?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2510702 Mark Earnest 2026-04-23 Goals of Care and the Importance of Being Polish An 86-year-old woman with a history of diabetes and breast cancer was admitted to the hospital with anorexia and weight loss. Imaging revealed multifocal liver lesions. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2412525?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2412525 Margaret M. Chapman, Rory L. Cochran, Kumar Krishnan, Kristen M. Hysell, Ahmad Alkashash 2026-04-23 Case 12-2026: An 86-Year-Old Woman with Anorexia, Weight Loss, and Liver Lesions Effective blood-pressure control is the cornerstone of management after intracerebral hemorrhage; it is both the primary determinant of risk and the most vital intervention for reducing the threat of a second vascular event.1 Yet, despite the availability of effective treatments, blood pressure remains poorly controlled in survivors of... https://www.nejm.org/doi/full/10.1056/NEJMe2600995?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2600995 Ayush Batra, Farzaneh Sorond 2026-04-23 Blood-Pressure Control after Intracerebral Hemorrhage — An Unbroken Glass Ceiling This Double Take video reviews heart failure with preserved ejection fraction, its risk factors and causes, and the challenge in establishing the diagnosis. https://www.nejm.org/doi/full/10.1056/NEJMp2516847?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516847 Sadiya Khan, Donald Lloyd-Jones, Neha J. Pagidipati, Sanjiv Shah, Susan Lehrer, Jane Leopold 2026-04-23 Double Take: HFpEF Explained — Prevalence, New Advances, and How to Diagnose An 87-year-old man presented with difficulty breathing after having inhaled thick smoke from a forest fire for several hours. Respiratory failure developed. On flexible bronchoscopy, black casts were seen in the airway. https://www.nejm.org/doi/full/10.1056/NEJMicm2518379?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2518379 Yuling Wang, Xiangdong Mu 2026-04-23 Bronchial Casts from Inhalation of Forest-Fire Smoke In this trial involving patients undergoing mechanical ventilation in the ICU, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2506398?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2506398 The SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group 2026-04-16 Selective Decontamination of the Digestive Tract during Ventilation in the ICU In a randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month. https://www.nejm.org/doi/full/10.1056/NEJMoa2511478?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2511478 Siyuan Lin, Yuanchen He, Lan He, Yiling Liu, Fangjie Wang, Zhenyu Xiong, Yixiang Lin, Lan Ye, Chen Chu, Feng Wang, Lu Zhao, Yinyin Cao, Yuanzheng Zheng, Qin Huang, Jie Wang, Xuecun Liang, Quming Zhao, Shuna Sun, Yalan Dou, Wennan He, Xiaobi Huang, Jingwei Sun, Xianmei Huang, Yan Li, Yanling Liao, Haitao Lv, Silin Pan, Hua Zhu, Xinjiang An, Xuehua He, Cuifen Zhao, Xiaoyan Liu, Yaofei Hu, Jinhua Piao, Lijun Qin, Xiangyu Dong, Qian Peng, Ce Wang, Shubin Lin, Ping Huang, Rongzhou Wu, Hua Peng, Zipu Li, Duolao Wang, Xiaohui Liu, Weili Yan, Fang Liu, Guoying Huang, the Chinese Kawasaki Disease Collaboration Network* 2026-04-16 Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2513880?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513880 Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh, the OCEANIC-STROKE Investigators* 2026-04-16 Asundexian for Secondary Stroke Prevention Combined oral contraceptives and hormone-replacement therapy increase the risk of venous thromboembolism, although the absolute risk is low. Transdermal estradiol and micronized progesterone carry lower risk. https://www.nejm.org/doi/full/10.1056/NEJMra2202438?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2202438 Leslie Skeith, Shannon M. Bates 2026-04-16 Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk This Double Take video reviews the differential diagnosis for a woman with night sweats and unintentional weight loss and how it evolves as new clinical findings are presented. https://www.nejm.org/doi/full/10.1056/NEJMp2516852?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516852 Sarah Gorey, Alison E. Burke, Natalie Koscal, Emily Ling, Nadine Tan, Caren G. Solomon 2026-04-16 Double Take: The Devil Is in the Details In the final NOS episode of the season, host Lisa Rosenbaum and her guests elucidate the quiet beauty of good primary care and consider how to induce the U.S. health care system to prize it more highly. https://www.nejm.org/doi/full/10.1056/NEJMp2514244?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2514244 2026-04-16 Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: When No One’s Watching — NOS Episode 3.12 A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during fever. Laboratory tests showed an elevated ESR and elevated C-reactive protein and ferritin levels. https://www.nejm.org/doi/full/10.1056/NEJMicm2514594?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2514594 Gabrielle Cognacq, Richard Stratton 2026-04-16 Adult-Onset Still’s Disease Despite the implementation of efficacious interventions for secondary prevention, patients with ischemic stroke or transient ischemic attack (TIA) remain at substantial residual risk for short- and long-term recurrent ischemic stroke and coronary events.1,2 Approximately three quarters of ischemic strokes or TIAs are noncardioembolic and may be attributable to... https://www.nejm.org/doi/full/10.1056/NEJMe2601859?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2601859 Marion Boulanger 2026-04-16 Asundexian for Noncardioembolic Ischemic Stroke