The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Mon, 20 Jul 2026 00:35:22 GMT 2026 NEJM Group en-us 1440 A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules. https://www.nejm.org/doi/full/10.1056/NEJMicm2603020?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603020 Rolter Lorenz M. Lee, Bonifacio C. Pedregosa II 2026-07-18 Neurocysticercosis In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death. https://www.nejm.org/doi/full/10.1056/NEJMp2516818?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516818 Tristan Jones 2026-07-18 Love and Death Health care–associated infections remain a major cause of illness across U.S. hospitals. In this cross-sectional study, the burden of such infections is compared between 2015 and 2023 with attention to changing definitions. https://www.nejm.org/doi/full/10.1056/NEJMoa2510881?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2510881 Nora Chea, Rongxia Li, Taniece Eure, Rebecca Alkis Ramirez, Joelle Nadle, Jane E. Lee, Monica Lehmann, Lyndzie Sardenga, Christopher A. Czaja, Helen Johnston, Melissa Kellogg, Catherine Emanuel, Alana Cilwick, Maria A. Correa, Meghan Maloney, Susan M. Ray, Jessica Howard-Anderson, Stacy Carswell, Lucy E. Wilson, Rebecca Perlmutter, Kaytlynn Marceaux-Galli, J.P. Mahoehney, Ruth Lynfield, Marla Sievers, Cory Cline, Melissa Judson, Ghinwa Dumyati, Christine Hurley, Elizabeth Keller, Marissa Walsh, Erin Licherdell, Julia Tellerman, Rebecca Pierce, Valerie L.S. Ocampo, Monika E. Samper, Kimberly A. Hires, Lauren T. Adrian, Roza P. Tammer, Alexia Zhang, Shannon Hiratzka, Angela Dusko, Christopher Wilson, Melphine Harriott, Henrietta Smith, Victoria Russo, LaTasha Boswell, Dominique Godfrey, Denise Leaptrot, Marissa McMeen, Melissa Otis, Jennifer Watkins, Amber Taylor, Rita Allen, Nicola D. Thompson, Jonathan R. Edwards, Shelley S. Magill, Cheri T. Grigg 2026-07-16 Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2516150?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Richard A. Furie, Maria Dall’Era, Edward M. Vital, Jay P. Garg, Fedra Irazoque Palazuelos, Adolfina E. Zuta Santillán, Jorge Ravelo-Hernández, Mittermayer B. Santiago, Beatriz Zazueta Montiel, Stella Botha, Piotr Leszczyński, Viviane Angelina de Souza, Sandra A. Sicsik, Luis Bellatin, Asokan Naidoo, Zahir Amoura, Maria Antonietta D’Agostino, Sunil Kumar, Biruh Workeneh, Julie Rae, Huiyan A. Mao, Felix Erblang, Oliver Meier, Justine C. Maller, Anca D. Askanase, the ALLEGORY Trial Investigators* 2026-07-16 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended. https://www.nejm.org/doi/full/10.1056/NEJMcp2411656?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2411656 David A. Williams, Daniel J. Clauw 2026-07-16 Fibromyalgia Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians. https://www.nejm.org/doi/full/10.1056/NEJMp2603126?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603126 Miguel A. Linares, Daniel Liauw, Lilia Cervantes 2026-07-16 The Exam Room as Sanctuary — Caring for Undocumented Patients Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach. https://www.nejm.org/doi/full/10.1056/NEJMp2602649?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602649 Yaara Zisman-Ilani, Ron Walfisch, Jeremy Veenstra-VanderWeele, David S. Mandell 2026-07-16 Pharmacotherapeutic Decisions in Autism A 6-month-old baby boy was transferred to a quaternary children’s hospital for seizures. A radiograph of a hand and wrist showed dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges. https://www.nejm.org/doi/full/10.1056/NEJMicm2603074?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603074 Jason Haines, Tony Huynh 2026-07-16 Lead Lines in Severe Lead Poisoning As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline. https://www.nejm.org/doi/full/10.1056/NEJMp2516621?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516621 Steven McGaughey 2026-07-16 The Symptom Tracker A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544 Aima A. Ahonkhai, Howard M. Heller, Sarah M. Schrader 2026-07-16 Case 20-2026: A 38-Year-Old Man with Abdominal Pain A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. https://www.nejm.org/doi/full/10.1056/NEJMicm2505469?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2505469 Maithili Charan Gattu, Mehul K 2026-07-16 Descending Thoracic Aortic Aneurysm Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach. https://www.nejm.org/doi/full/10.1056/NEJMc2601997?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2601997 Tadej Avčin, Andreas Reiff, Maša Bizjak, Barbara Jenko Bizjan, Tina Vesel Tajnšek, Maruša Debeljak, Tyler Artner, Bernd Jilma, Christian Lood, Abdul Hakkim, Tobias A. Fuchs 2026-07-16 Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency In a phase 3 trial involving patients with idiopathic pulmonary fibrosis, inhaled treprostinil was associated with a smaller decline in forced vital capacity and a lower risk of clinical worsening than placebo over 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2512911?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2512911 Steven D. Nathan, Peter Smith, Chunqin Deng, Maria De Salvo, Wim Wuyts, Juana Pavie-Gallegos, Jin Woo Song, Mordechai R. Kramer, Christopher S. King, John A. Mackintosh, Daniel Chambers, Georgina Viviana Miranda, Natalie Breytenbach, Leigh Peterson, Heidi Bell, Kevin R. Flaherty, Juergen Behr, Vincent Cottin, the TETON-2 Trial Investigators* 2026-07-09 Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis Among participants 4 to 66 years of age with acquired hypothalamic obesity, setmelanotide, a melanocortin-4 receptor agonist, led to significantly greater reductions in body-mass index and hunger than placebo at 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2512275?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2512275 Jennifer L. Miller, Hanneke M. van Santen, Susan A. Phillips, Jill Hamilton, Jens Aberle, Thozhukat Sathyapalan, Zainaba Mohamed, Shana E. McCormack, Ashley H. Shoemaker, Megan M. Kelsey, Luma Ghalib, Guenter Stalla, Vidhu V. Thaker, Reema Habiby, Katie Larson Ode, Martin Wabitsch, Mehul Dattani, M. Jennifer Abuzzahab, Hussein Abdullatif, Ryan Morgan, Margaret Stefater-Richards, Vanita R. Aroda, Carsten Friedrich, Joan C. Han, Hiraku Ono, Keisuke Nagasaki, Tomohiro Tanaka, Tsuyoshi Isojima, Hiroshi Arima, Cecilia Scimia, Guojun Yuan, Hermann L. Müller, Christian L. Roth, the TRANSCEND Trial Group* 2026-07-09 Setmelanotide for the Treatment of Acquired Hypothalamic Obesity Among patients with idiopathic pulmonary fibrosis, inhaled treprostinil led to a smaller decline in forced vital capacity than placebo over 52 weeks. Cough and drug discontinuation were more common with treprostinil. https://www.nejm.org/doi/full/10.1056/NEJMoa2501488?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2501488 Steven D. Nathan, Peter Smith, Chunqin Deng, Christopher S. King, Maria De Salvo, S. Samuel Weigt, Sahil Pandya, Debabrata Bandyopadhyay, Joseph A. Lasky, Rachana Krishna, Nathan Hambly, Murali Ramaswamy, Jad Kebbe, Neil Ettinger, Jamie Gao, Youlan Rao, Natalie Breytenbach, Leigh Peterson, Heidi Bell, Juergen Behr, Vincent Cottin, Kevin R. Flaherty, the TETON-1 Trial Investigators* 2026-07-09 Phase 3 Trials of Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis An ICU physician believed letting her father die at home meant comfort, dignity, control, family close by, and the quiet reassurance of hospice. But she didn’t realize what it would require of her family. https://www.nejm.org/doi/full/10.1056/NEJMp2517154?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2517154 Danielle D. DeCourcey 2026-07-09 For Those Left Behind A 68-year-old man was evaluated in an outpatient clinic because of fatigue and dyspnea. Lung transplantation had been performed 15 months earlier. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517856?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517856 Hilary J. Goldberg, Harikrishnan Nandakumar, Brian C. Keller, Lida P. Hariri, Arthur Y. Kim, Briana N. Castillo 2026-07-09 Case 19-2026: A 68-Year-Old Man with Fatigue, Fever, and Hypoxemia Growing acceptance of voluntary euthanasia, which opens the door to death by organ donation, warrants a recontextualization of the dead donor rule and assessment of the ethical principles involved. https://www.nejm.org/doi/full/10.1056/NEJMms2601611?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMms2601611 Carter Winberg, Ian Ball, Robert D. Truog 2026-07-09 Contextualizing the Dead Donor Rule in an Era of Voluntary Euthanasia A 71-year-old man was found to have a tapeworm (shown in a video) in his peritoneal cavity during elective repair of a right inguinal hernia. He recalled having consumed raw snake meat during his military service 50 years earlier. https://www.nejm.org/doi/full/10.1056/NEJMicm2603440?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603440 Chang-Seop Lee, Yeon Jun Jeong 2026-07-09 Sparganosis A 42-year-old man with a recent stem-cell transplant presented with a 2-week history of urinary frequency and weak stream. Papules were seen on the penile shaft. Urethroscopy showed papillomatous lesions on the urethral mucosa. https://www.nejm.org/doi/full/10.1056/NEJMicm2603369?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603369 Jung Hoon Bae, Hyong Woo Moon 2026-07-09 Condyloma Acuminata of the Urethra