The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Clinical Medicine. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Tue, 28 Jul 2026 03:10:51 GMT 2026 NEJM Group en-us 1440 As legislative support for medical aid in dying grows, the paradox at the heart of this option, with its broader-than-expected benefits, becomes increasingly clear: its expansion hinges on its rarity. https://www.nejm.org/doi/full/10.1056/NEJMp2606019?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2606019 Mara Buchbinder 2026-07-25 The Paradox of Medical Aid in Dying When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion. https://www.nejm.org/doi/full/10.1056/NEJMp2517208?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2517208 Brendan M. Reilly 2026-07-25 Braking Bad News A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2601392?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2601392 André Vaz, Lucas Araújo 2026-07-25 Pulsatile Liver in Severe Tricuspid Regurgitation The Trump administration’s legal theories about gender-affirming care, if accepted, could shift the equilibrium of medical decision making in the United States in important ways. https://www.nejm.org/doi/full/10.1056/NEJMp2605975?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605975 Benjamin A. Barsky, Brendan Reid, Christopher Robertson 2026-07-25 Medical Standards by Federal Fiat In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2601103?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601103 Joseph W. Rossano, Charles Canter, Cordula M. Wolf, Andrew Papez, Marta Gambra, Randall M. Bryant, Juan Alejos, Michael McCulloch, Georgia Sarquella Brugada, Matthew J. Bock, Aamir Jeewa, F. Bennett Pearce, Milind Y. Desai, Nicholas Favatella, Atefeh Javidialsaadi, Van Phung, Thomas Rano, Lin Zhu, Joshua L. Dyme, Seema Mital, the SCOUT-HCM Investigators* 2026-07-23 Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules. https://www.nejm.org/doi/full/10.1056/NEJMicm2603020?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603020 Rolter Lorenz M. Lee, Bonifacio C. Pedregosa II 2026-07-23 Neurocysticercosis In the ICU, a resident is surrounded by deaths, each one leaving him with a sense of emptiness. Then a Christmas tragedy highlights medicine’s privilege of bearing witness to love as well as death. https://www.nejm.org/doi/full/10.1056/NEJMp2516818?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516818 Tristan Jones 2026-07-23 Love and Death A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086 Aubrey L. Gilbert, Bart K. Chwalisz, Racine S. Gue, Lisa M. Bebell 2026-07-23 Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye A 35-year-old man with well-controlled plaque psoriasis presented with new skin lesions. Two weeks earlier, he had undergone wet cupping. Physical examination revealed erythematous, scaly papules and plaques on his back. https://www.nejm.org/doi/full/10.1056/NEJMicm2603647?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603647 Yusuf Demir, Zekayi Kutlubay 2026-07-23 Koebner Phenomenon from Wet Cupping The more capable an AI copilot appears, the more likely clinicians are to offload tasks to it, eroding skills required for detecting its errors. CRM can help overcome this “automation paradox.” https://www.nejm.org/doi/full/10.1056/NEJMp2600938?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600938 Raja-Elie E. Abdulnour, Hossein Akbarialiabad, Alireza Haghighi, Sancy A. Leachman 2026-07-22 Crew Resource Management — Navigating AI’s Automation Paradox Health care–associated infections remain a major cause of illness across U.S. hospitals. In this cross-sectional study, the burden of such infections is compared between 2015 and 2023 with attention to changing definitions. https://www.nejm.org/doi/full/10.1056/NEJMoa2510881?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2510881 Nora Chea, Rongxia Li, Taniece Eure, Rebecca Alkis Ramirez, Joelle Nadle, Jane E. Lee, Monica Lehmann, Lyndzie Sardenga, Christopher A. Czaja, Helen Johnston, Melissa Kellogg, Catherine Emanuel, Alana Cilwick, Maria A. Correa, Meghan Maloney, Susan M. Ray, Jessica Howard-Anderson, Stacy Carswell, Lucy E. Wilson, Rebecca Perlmutter, Kaytlynn Marceaux-Galli, J.P. Mahoehney, Ruth Lynfield, Marla Sievers, Cory Cline, Melissa Judson, Ghinwa Dumyati, Christine Hurley, Elizabeth Keller, Marissa Walsh, Erin Licherdell, Julia Tellerman, Rebecca Pierce, Valerie L.S. Ocampo, Monika E. Samper, Kimberly A. Hires, Lauren T. Adrian, Roza P. Tammer, Alexia Zhang, Shannon Hiratzka, Angela Dusko, Christopher Wilson, Melphine Harriott, Henrietta Smith, Victoria Russo, LaTasha Boswell, Dominique Godfrey, Denise Leaptrot, Marissa McMeen, Melissa Otis, Jennifer Watkins, Amber Taylor, Rita Allen, Nicola D. Thompson, Jonathan R. Edwards, Shelley S. Magill, Cheri T. Grigg 2026-07-16 Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2516150?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Richard A. Furie, Maria Dall’Era, Edward M. Vital, Jay P. Garg, Fedra Irazoque Palazuelos, Adolfina E. Zuta Santillán, Jorge Ravelo-Hernández, Mittermayer B. Santiago, Beatriz Zazueta Montiel, Stella Botha, Piotr Leszczyński, Viviane Angelina de Souza, Sandra A. Sicsik, Luis Bellatin, Asokan Naidoo, Zahir Amoura, Maria Antonietta D’Agostino, Sunil Kumar, Biruh Workeneh, Julie Rae, Huiyan A. Mao, Felix Erblang, Oliver Meier, Justine C. Maller, Anca D. Askanase, the ALLEGORY Trial Investigators* 2026-07-16 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended. https://www.nejm.org/doi/full/10.1056/NEJMcp2411656?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2411656 David A. Williams, Daniel J. Clauw 2026-07-16 Fibromyalgia Caring for undocumented immigrants at a time of heightened fear requires actionable frameworks guided by compassion and respect. Trauma-informed care is a vital approach for physicians. https://www.nejm.org/doi/full/10.1056/NEJMp2603126?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603126 Miguel A. Linares, Daniel Liauw, Lilia Cervantes 2026-07-16 The Exam Room as Sanctuary — Caring for Undocumented Patients Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach. https://www.nejm.org/doi/full/10.1056/NEJMp2602649?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602649 Yaara Zisman-Ilani, Ron Walfisch, Jeremy Veenstra-VanderWeele, David S. Mandell 2026-07-16 Pharmacotherapeutic Decisions in Autism A 6-month-old baby boy was transferred to a quaternary children’s hospital for seizures. A radiograph of a hand and wrist showed dense, transverse bands of metaphyseal sclerosis in the radius, ulna, metacarpals, and phalanges. https://www.nejm.org/doi/full/10.1056/NEJMicm2603074?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603074 Jason Haines, Tony Huynh 2026-07-16 Lead Lines in Severe Lead Poisoning As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline. https://www.nejm.org/doi/full/10.1056/NEJMp2516621?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516621 Steven McGaughey 2026-07-16 The Symptom Tracker A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544 Aima A. Ahonkhai, Howard M. Heller, Sarah M. Schrader 2026-07-16 Case 20-2026: A 38-Year-Old Man with Abdominal Pain A man presented with a 2-month history of chest heaviness and a 2-week history of shortness of breath. Pulsations were visible between his ribs (shown in a video). Ultrasonography revealed a rounded structure near the heart. https://www.nejm.org/doi/full/10.1056/NEJMicm2505469?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2505469 Maithili Charan Gattu, Mehul K 2026-07-16 Descending Thoracic Aortic Aneurysm Recombinant DNASE1L3 therapy reduced symptoms in a patient with severe lupus with DNASE1L3 deficiency. Antidrug antibodies caused effects to wane, but findings support NET-targeted therapy as a nonimmunosuppressive approach. https://www.nejm.org/doi/full/10.1056/NEJMc2601997?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2601997 Tadej Avčin, Andreas Reiff, Maša Bizjak, Barbara Jenko Bizjan, Tina Vesel Tajnšek, Maruša Debeljak, Tyler Artner, Bernd Jilma, Christian Lood, Abdul Hakkim, Tobias A. Fuchs 2026-07-16 Targeted Degradation of NETs in Lupus with DNASE1L3 Deficiency