The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Gastroenterology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Mon, 10 Aug 2026 09:47:24 GMT 2026 NEJM Group en-us 1440 A 60-year-old man presented with a 1-month history of postprandial epigastric pain. CT of the abdomen showed a diffusely enlarged pancreas with a capsule-like rim. Serum levels of IgG4 were elevated. https://www.nejm.org/doi/full/10.1056/NEJMicm2604806?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2604806 Atsuto Kayashima, Masayasu Horibe 2026-08-06 Type 1 Autoimmune Pancreatitis Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy. https://www.nejm.org/doi/full/10.1056/NEJMoa2600743?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600743 Jonathan Barratt, Necmi Eren, Naoki Kashihara, Bart Maes, Dana V. Rizk, Brad Rovin, Hernán Trimarchi, Hong Zhang, Weiming Wang, Ismail Kocyigit, Chuanming Hao, Vladimir Tesař, Kenan Turgutalp, Li Yang, Guangqun Xing, Valter Duro Garcia, Seung Hyeok Han, Wanhong Lu, Antonio Pisani, Julia Weinmann-Menke, Frank Eitner, Nicolas Guerard, Dmytro Butylin, Luca Monaco, Emil Scosyrev, Annabel Magirr, Ronny Renfurm, Thomas Hach, Vlado Perkovic, the APPLAUSE-IgAN Study Group* 2026-07-30 Iptacopan in IgA Nephropathy — Final 24-Month Data A 51-year-old woman with right heart failure presented with worsening abdominal distention and leg swelling. Examination was notable for ascites, leg edema, a grade 4/6 holosystolic murmur, and a pulsatile liver (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2601392?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2601392 André Vaz, Lucas Araújo 2026-07-30 Pulsatile Liver in Severe Tricuspid Regurgitation Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. https://www.nejm.org/doi/full/10.1056/NEJMoa2605555?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2605555 Eileen M. O’Reilly, Zev A. Wainberg, Andrew E. Hendifar, Mitesh J. Borad, Filippo Pietrantonio, Shubham Pant, Pascal Hammel, Chiara Cremolini, Gulam A. Manji, Paul E. Oberstein, Ignacio Garrido-Laguna, Christoph Springfeld, Nilofer S. Azad, Makoto Ueno, Stephen Y. Chui, Ying Zhang, Hina Patel, Yeonju Lee, Zeena Salman, Brian M. Wolpin, the RASolute 302 Trial Investigators* 2026-07-23 Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system. https://www.nejm.org/doi/full/10.1056/NEJMp2602773?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602773 Josiah D. Rich, Karla Thornton, Matthew J. Akiyama 2026-07-23 National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails For decades, pancreatic ductal adenocarcinoma (PDAC) has been perhaps the clearest example of a cancer that is driven by a dominant oncogenic event yet is resistant to therapeutic exploitation. More than 90% of pancreatic cancers harbor activating RAS mutations, most commonly those involving KRAS codon 12,... https://www.nejm.org/doi/full/10.1056/NEJMe2606948?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2606948 Shivan Sivakumar 2026-07-23 Breaking the RAS Barrier in Pancreatic Cancer A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544 Aima A. Ahonkhai, Howard M. Heller, Sarah M. Schrader 2026-07-16 Case 20-2026: A 38-Year-Old Man with Abdominal Pain During the acute phase of critical illness, early restrictive-dose enteral nutrition is preferred over parenteral nutrition to support gut integrity. Full-dose enteral nutrition increases the risk of adverse effects. https://www.nejm.org/doi/full/10.1056/NEJMra2506111?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2506111 Jayshil J. Patel, Stephen A. McClave 2026-07-09 Nutrition Therapy in Critically Ill Adults This feature about treatment of appendicitis offers a case vignette accompanied by two essays, one recommending operative management and the other supporting a nonoperative approach. https://www.nejm.org/doi/full/10.1056/NEJMclde2600182?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMclde2600182 Katerina Lin, Theodore N. Pappas, Dimitrios P. Moris, David R. Flum 2026-07-02 Operative versus Nonoperative Management for Appendicitis This artificial intelligence–derived and validated machine-learning system appeared to predict the risk of Hirschsprung disease with the use of genetic and demographic data from participants in China. https://www.nejm.org/doi/full/10.1056/NEJMc2401139?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2401139 Yang Wang, Xingjie Hao, Zhonghua Yang, Allan M. Goldstein 2026-07-02 Artificial Intelligence and Detection of Hirschsprung Disease In two phase 3 trials, 19% of patients with chronic hepatitis B infection had a functional cure with the antisense oligonucleotide bepirovirsen, 24 weeks after stopping all HBV treatment; functional cure was not seen with placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2515131?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515131 Jinlin Hou, Seng-Gee Lim, Maria Buti, Man-Fung Yuen, Edward Gane, Pietro Lampertico, Norah Terrault, Huy Nguyen, Hyung Joon Yim, Qing Xie, Jianmei Lin, Yunqing Qiu, Wen-Juei Jeng, Jeong Heo, Cheng-Yuan Peng, Chien-Hung Chen, Wan-Long Chuang, Yao Xie, Maria Hlebowicz, Nevin Idriz, Rajiv Mehta, Kosh Agarwal, Monica M. Gomes da Silva, Alex Franca, Roxana Cernat, Apinya Leerapun, Carla S. Coffin, Adrian Gadano, Pietro Andreone, Shigetoshi Fujiyama, Vasileios Sevastianos, Yuichiro Suzuki, Vlad Ratziu, Ghassan Riachi, Hartmut Stocker, Tien Huey Lim, Tarik Asselah, Yasuhito Tanaka, Jacinta Holmes, Xieer Liang, Jennifer Cremer, Tamara Lukić, Helene Plein, Geoff Quinn, Yu Tao, Melanie Paff, Dickens Theodore, Robert Elston, the B-Well Study Group* 2026-06-25 Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection Peanuts should be introduced at 4 to 6 months of age in infants at high risk for allergy and at approximately 6 months of age in other infants. For infants with peanut allergy, early immunotherapy is safer and more effective. https://www.nejm.org/doi/full/10.1056/NEJMcp2314424?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2314424 George Du Toit, Gideon Lack 2026-06-25 Prevention and Treatment of Peanut Allergy The current treatment of chronic hepatitis B infection includes nucleoside or nucleotide analogue (NA) therapy and pegylated interferon. Both of these treatments are effective in suppressing hepatitis B virus (HBV) replication and in reducing the risk of cirrhosis and hepatocellular carcinoma.1 However, these treatments do not eradicate HBV,... https://www.nejm.org/doi/full/10.1056/NEJMe2605575?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2605575 Anna S. Lok 2026-06-25 A Major Step toward a Cure for Hepatitis B Infection A 66-year-old man with a history of Crohn’s disease treated with long-term adalimumab presented with fever and swelling of both knees. Analysis of a biopsy sample of the left knee synovium showed an atypical T-cell infiltrate. https://www.nejm.org/doi/full/10.1056/NEJMicm2501877?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2501877 Edward Robert Scheffer Cliff, Melita Kenealy 2026-06-18 Immunosuppression-Associated Peripheral T-Cell Lymphoma Neutralizing interleukin-10 autoantibodies were found in a subgroup of patients with inflammatory bowel disease and in no controls without IBD. Seropositivity was strongly associated with the IBD HLA-DRB1*01:03 risk allele. https://www.nejm.org/doi/full/10.1056/NEJMoa2513654?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513654 Nima Gharahdaghi, Pai-Jui Yeh, Lourdes Ceron-Gutierrez, Helen Griffin, Hannah Gordon, Chamara Jayamanne, Alice Fracchia, Amanda Y. Chong, Alissa Walsh, Oliver Brain, Katherine Baker, Hannah Kockelbergh, Yang Luo, Martha Guevara Becerra, Katherine Vadakethala, Madeleine Coy, Ladan Kabiri, Martin Barnardo, Susanna Dunachie, Barbara Kronsteiner, Anna Adams, Darren Fowler, Qian Zhang, Laura Fachal, Carl A. Anderson, Rofaida Desoki, Marie Vibeke Vestergaard, Lone Larsen, Nicola J. Wyatt, Robert D. Lees, Robert J. Mulligan, Chaonan Dong, Mohmmed Tauseef Sharip, Siân E. Faustini, Adrian Shields, Julia Pakpoor, Bushra Naz, Alex Richter, Jack Satsangi, Christopher A. Lamb, Miles Parkes, Fiona Powrie, Alexander J. Mentzer, Aleksejs Sazonovs, Tine Jess, Paul Klenerman, Simon Travis, Sophie Hambleton, Rainer Doffinger, Holm H. Uhlig 2026-06-11 Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease The authors describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease. https://www.nejm.org/doi/full/10.1056/NEJMe2603635?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603635 Paul Bastard, Jean-Laurent Casanova 2026-06-11 Science behind the Study: Autoantibodies against Cytokines — From Infection to Inflammation If the current cholera pandemic, which began in 1961, is ever to end, the world will need better cholera vaccines that are effective in young children and global access to safe water and adequate sanitation. https://www.nejm.org/doi/full/10.1056/NEJMp2600873?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600873 Edward T. Ryan, Firdausi Qadri, Julia A. Lynch 2026-06-11 Global Cholera-Control Efforts — Progress and Remaining Challenges A 53-year-old man with Crohn’s disease and psoriasis presented with a 2-day history of headache, slurred speech, nausea, and vomiting. During the previous 2 weeks, he had had yellowing of the skin and eyes and dark urine. https://www.nejm.org/doi/full/10.1056/NEJMcps2506943?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcps2506943 Brittany B. Bromfield, Nikroo Hashemi, Mark S. Redston, Katherine H. Walker, Bruce D. Levy 2026-06-04 The Unusual Suspects A study dissects the way in which fasting or a fasting-mimicking diet augments the effect of hormonal therapy in a mouse model of breast cancer. https://www.nejm.org/doi/full/10.1056/NEJMcibr2600647?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcibr2600647 Nima Sharifi 2026-06-04 Fasting, Glucocorticoids, and Breast Cancer A 44-year-old man presented with a 4-year history of choking episodes while eating. Endoscopy revealed narrowing of the upper esophagus by a pulsating, cordlike structure in the posterior wall (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2600585?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2600585 Ishita Dubey, Neha Wadhwa 2026-06-04 Dysphagia Lusoria