The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Infectious Disease. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Tue, 12 May 2026 06:23:36 GMT 2026 NEJM Group en-us 1440 A 50-year-old man presented to the ED with a 1-month history of headache and worsening weakness of the left arm and leg. Brain MRI showed an enhancing lesion with extensive surrounding edema. https://www.nejm.org/doi/full/10.1056/NEJMicm2518333?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2518333 Ke Xiao, Ying Si 2026-05-09 Cerebral Syphilitic Gumma Among adults 50 years of age or older, fewer cases of confirmed influenza-like illness were observed with an mRNA influenza vaccine than with standard vaccines. Reactogenicity was higher with the mRNA vaccine. https://www.nejm.org/doi/full/10.1056/NEJMoa2516491?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516491 Isabel Leroux-Roels, Grace Huang, Murdo Ferguson, Anita Kohli, Rebecca Clark, Markus Bickel, Mieke Soens, Evelyn Du, Alicia Pucci, Bryony Hicks, Colbie Eschen, Rituparna Das, Eleanor Wilson, the Fluent Trial Investigators* 2026-05-07 Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults In this randomized trial, higher-dose ivermectin plus permethrin was no better than standard-dose ivermectin plus permethrin, but both regimens were effective, leading to cure in 75% and 82% of the patients, respectively. https://www.nejm.org/doi/full/10.1056/NEJMoa2411721?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2411721 Charlotte Bernigaud, Giao Do-Pham, Elie Guichard, Marie Beylot-Barry, Elisa Goujon, Camille Isnard, Nathalie Beneton, Mahtab Samimi, Billal Tedbirt, Henri Adamski, Selma Azib, Emmanuel Mahé, Catherine Michel, Jean-Luc Perrot, Marie Acquitter, Anne-Claire Bursztejn, Guillaume Chaby, Frédéric Caux, Thierry Passeron, Clélia Vanhaecke, Antoine Mahé, Marie-Thérèse Leccia, Sébastien Barbarot, Cédric Lenormand, François Aubin, Françoise Foulet, Laëtitia Grégoire, Bruno Giraudeau, Olivier Chosidow 2026-05-07 Combined Oral Ivermectin and 5% Permethrin Cream to Treat Severe Scabies A 22-year-old man presented with a 5-day history of painful lesions on his hands, feet, lips, and tongue. Physical examination showed erosions on the tongue and target lesions on the palms. https://www.nejm.org/doi/full/10.1056/NEJMicm2517901?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2517901 Inês Pereira Amaral, Joana Antunes 2026-05-07 Erythema Multiforme A 62-year-old man was admitted to the hospital for malaise, anorexia, rash, and diffuse lymphadenopathy. Fatigue and anorexia began 6 months earlier. Four months before admission, a pruritic rash developed on the back and spread. https://www.nejm.org/doi/full/10.1056/NEJMcps2511351?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcps2511351 Masami Matsumura, Naoki Kanda, Shuji Hatakeyama, Gurpreet Dhaliwal 2026-05-07 Immune Interference In a study involving 180 blood bags, use of a double-knot closure rather than the usual single knot prevented bacterial contamination. This strategy may reduce the risk of blood-product contamination in resource-limited settings. https://www.nejm.org/doi/full/10.1056/NEJMc2600589?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2600589 Kathleen Selleng, Halima Ismail, Christian Kohler, Jan Wesche, Jessica Fuhrmann, Anne Kohler, Claudia Wiede, Vivien Huj, Yazid Ibrahim, Evgeny A. Idelevich, Dalhat Gwarzo, Andreas Greinacher 2026-05-07 Reducing Bacterial Contamination of Blood Bags with a Double Knot Avian influenza can jump species from birds to humans, a fact that arouses concern for serious illness and broader human transmission. In this report, avian influenza A(H5N5) was shown to cause severe human illness. https://www.nejm.org/doi/full/10.1056/NEJMc2518178?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518178 Thuy-Lan Lite, Stephanie Goya, Margaret L. Davis, Amy E. Morris, Chloe Bryson-Cahn, Alexander Vengerovsky, Carlos G. Corpuz, B. Ethan Nunley, Janine R. Maenza, Thomas R. Hawn, Andrew M. Luks, John B. Lynch, Timothy M. Uyeki, Helen Y. Chu, Alexander L. Greninger, Clifford C. Sung 2026-05-07 Human Infection with Highly Pathogenic Avian Influenza A(H5N5) Virus This cluster-randomized trial in Malawi and Uganda showed a significant benefit of an intervention to support health care providers in hand washing, preventing and managing maternal infection, and detecting and treating sepsis. https://www.nejm.org/doi/full/10.1056/NEJMoa2512698?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2512698 David Lissauer, Luis Gadama, Catriona Waitt, Sonia Whyte, Girvan Burnside, Aiswarya Anilkumar, Regina Makuluni, Peace Okwaro, Liu Yang, Peter Waitt, Owen Musopole, Rosemary Bilesi, Bertha Maseko, Joel Lwasa, Richard Mugahi, Charles Olaro, Mohammed Lamorde, Mirriam Makuta, Chimwemwe Kachiwaya, Tionge Mkandawire, Adrian Malunga, Nyadani Chitsulo, Prisca Abitimo, Tabitha Ayabo, Andrew Weeks, James Martin, Karla Hemming, Ioannis Gallos, Edward J. M. Monk, Jennifer Riches, Chikondi Chapuma, Judith Nanyondo S., Fabiana Lorencatto, Mark Monahan, Benedetta Allegranzi, Catherine Dunlop, Lou Atkins, Anna Rosala-Hallas, Tracy Roberts, Carrol Gamble, Address Malata, Nicola Desmond, Edward Kommwa, Abi Merriel, William Parry-Smith, Rebecca Smith, Ivy Ndumu, Eleanor Williams, Bob Faque, Gertrude Banda, Alinane L. Nyondo-Mipando, Adelline Twimukye, Tim Chater, Aristotelis Diplas, Vanessa Brizuela, Joao Paulo Souza, Jamie Rylance, James Cheshire, Lydia Hawker, Arri Coomarasamy, Mercedes Bonet 2026-04-30 A Multicomponent Intervention to Improve Maternal Infection Outcomes Rapid, affordable, and easy-to-use diagnostic testing for tuberculosis is needed. In a multinational study, the accuracy of a tuberculosis diagnostic deployable to peripheral health care centers was assessed. https://www.nejm.org/doi/full/10.1056/NEJMoa2509761?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2509761 Seda Yerlikaya, Masuzyo Chirwa, Bukola Ajide, Maria del Mar Castro, Huy Ha, Midori Kato-Maeda, Esther Kisakye, Danaida Marcelo, Tessa Mochizuki, Loren Rockman, Amy Steadman, Balamugesh Thangakunam, John Samson Bimba, Devasahayam J. Christopher, Monde Muyoyeta, Ha Phan, Grant Theron, Charles Yu, Kristin Kremer, Patrick P.J. Phillips, Payam Nahid, Claudia M. Denkinger, Adithya Cattamanchi, Alfred Andama, the R2D2 TB Network and SMART4TB Consortia* 2026-04-30 Pulmonary Tuberculosis Detection with MiniDock MTB Using Swab Samples A 30-year-old man who worked as an agricultural laborer presented with a 2-year history of skin lesions on his right foot. Examination was notable for swelling of the right foot with overlying ulcerated nodules. https://www.nejm.org/doi/full/10.1056/NEJMicm2515474?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2515474 Juan C. Cataño, Valentina Montoya 2026-04-30 Mycetoma A 76-year-old woman, who had a history of treated hepatitis C virus infection, presented with rapidly progressive kidney failure and a stroke. Palpable purpura on the legs was noted. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517862?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517862 Frank B. Cortazar, Meghan E. Sise, Otto Rapalino, Andrew R. Branagan, Claire Trivin-Avillach 2026-04-30 Case 13-2026: A 76-Year-Old Woman with Fatigue, Rash, and Kidney Failure In the mid-19th century, the Hungarian physician Ignaz Semmelweis’s observations and theories about the transfer of “cadaverous particles” on the hands of doctors led to the development of hygiene protocols, such as hand washing with chlorine, which resulted in a reduction in maternal mortality associated with puerperal fever.1,2 ... https://www.nejm.org/doi/full/10.1056/NEJMe2518018?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518018 James A. Berkley 2026-04-30 Tackling Maternal Sepsis — Doing the Basics, and Doing Them Well A physician offers to help in a medical emergency on a transatlantic flight. Though she faces limits of bureaucracy, equipment, and ultimately biology, she discovers her physicianhood is inescapable. https://www.nejm.org/doi/full/10.1056/NEJMp2511971?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2511971 Elizabeth Rourke 2026-04-30 Shock Not Advised A Tennessee bill focused on directed blood donation exemplifies a pattern of efforts to legislate medical practice in ways that override scientific consensus while invoking the language of autonomy. https://www.nejm.org/doi/full/10.1056/NEJMp2602587?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602587 Jeremy W. Jacobs, Nikki B. Zite, Miriam Brown, Sarah S. Osmundson, Deva Sharma 2026-04-30 Legislating Medicine — Directed Donation and the Politics of Patient Choice In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-04-24 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock In two open-label trials, nirmatrelvir–ritonavir did not reduce the incidence of hospitalization or death among vaccinated higher-risk participants with SARS-CoV-2 infection. https://www.nejm.org/doi/full/10.1056/NEJMoa2502457?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2502457 Christopher C. Butler, Andrew D. Pinto, Victoria Harris, Jane Holmes, Najib M. Rahman, Lucy Cureton, Gail Hayward, Duncan B. Richards, David M. Lowe, Joseph F. Standing, Judith Breuer, Kerenza Hood, May Ee Png, Stavros Petrou, Jienchi Dorward, Mahendra G. Patel, Nicholas P.B. Thomas, Philip Evans, Nigel D. Hart, Bhautesh D. Jani, Banafshe Hosseini, Srinivas Murthy, Kerry McBrien, Amanda Condon, Emily G. McDonald, Peter Daley, Michelle Greiver, Bruno R. da Costa, Peter Selby, Peter Jüni, Todd C. Lee, Haolun Shi, Michelle A. Detry, Christina T. Saunders, Mark Fitzgerald, Nicholas S. Berry, Benjamin R. Saville, Saye H. Khoo, Jonathan S. Nguyen-Van-Tam, F.D. Richard Hobbs, Ly-Mee Yu, Paul Little, the PANORAMIC Trial and CanTreatCOVID Trial Collaborative Groups* 2026-04-23 Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients Spinal epidural abscess is an infection in the epidural space commonly caused by Staphylococcus aureus. Symptoms include back pain, neck pain, fever, and neurologic symptoms. Prompt evaluation is important. https://www.nejm.org/doi/full/10.1056/NEJMra2412728?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2412728 Aaron J. Tande, Bradford L. Currier, Douglas R. Osmon 2026-04-23 Spinal Epidural Abscess Consolidation in drug markets could promote availability of innovative treatments. But current antitrust screening is inadequate for detecting anticompetitive behavior, including “killer acquisitions.” https://www.nejm.org/doi/full/10.1056/NEJMp2516842?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516842 S. Sean Tu, Jaime King 2026-04-23 Anticompetitive Mergers — Pharmaceutical Buyouts as a Strategy for Maintaining Market Dominance A 74-year-old man presented with a painful laceration on his leg that he had sustained 3 days earlier in waters off the Gulf Coast of Florida. Ecchymosis, swelling, and crepitus were observed in the lower leg. https://www.nejm.org/doi/full/10.1056/NEJMicm2600207?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2600207 Natalie Rosseau, Norman L. Beatty 2026-04-23 Vibrio vulnificus Necrotizing Soft-Tissue Infection The first cases of Covid-19 were reported at the end of 2019, and from January 20, 2020, to May 5, 2023, Covid-19 was considered to be a public health emergency of international concern. The total number of cases worldwide exceeded 1 million by early April 2020. In the United States,... https://www.nejm.org/doi/full/10.1056/NEJMe2603127?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603127 H. Clifford Lane, Anthony S. Fauci 2026-04-23 Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir