The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Infectious Disease. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Tue, 11 Aug 2026 11:18:57 GMT 2026 NEJM Group en-us 1440 The lack of vaccines and disease-specific therapeutics for Bundibugyo Ebola has dramatically affected the community’s perception of Ebola treatment centers. In this context, trust becomes critical. https://www.nejm.org/doi/full/10.1056/NEJMp2607429?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607429 Serge Tonen-Wolyec, Laurent Bélec 2026-08-06 The Social Contract of Bundibugyo Ebola Isolation An accurate history of Ebola begins with partnerships, including those between responders and the populations they serve. One of its key lessons is that equity must be integral to outbreak preparedness. https://www.nejm.org/doi/full/10.1056/NEJMp2607819?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607819 Alimuddin Zumla, Francine Ntoumi, Nicaise Ndembi, Sabue Mulangu, Peter Piot, Jean-Jacques Muyembe-Tamfum, Jean B. Nachega 2026-08-06 Ebola at 50 — Lessons for Outbreak Response and Preparedness Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness. https://www.nejm.org/doi/full/10.1056/NEJMp2607839?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607839 Matthew M. Kavanagh, Joseph E. Stiglitz, Monica Geingos, Winnie Byanyima, Michael G. Marmot, the Global Council on Inequality, AIDS, and Pandemics 2026-08-06 The Inequality–Pandemic Cycle — Rethinking Preparedness The Bundibugyo virus outbreak in the DRC and Uganda has focused concern on potential countermeasures. Investigators assessed cross-reactive immune responses in serum obtained during previous Ebola vaccine trials. https://www.nejm.org/doi/full/10.1056/NEJMc2608018?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2608018 Edouard Lhomme, Aurélie Wiedemann, Ahidjo Ayouba, Safaa Ben-Farhat, Guillaume Thaurignac, Céline Roy, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Bailah Leigh, Samba Sow, Stephen A. Migueles, Deborah Watson-Jones, Yazdan Yazdanpanah, Rodolphe Thiébaut, Martine Peeters, Laura Richert, Yves Levy, for the PREVAC Study Team* 2026-08-06 Cross-Reactive Bundibugyo Antibody Responses after Receipt of Licensed Ebola Vaccines Bundibugyo virus, a filovirus, is currently spreading in the Democratic Republic of Congo. This report presents early data on symptoms and illness severity as well as diagnostic challenges. https://www.nejm.org/doi/full/10.1056/NEJMc2608070?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2608070 Pierre Akilimali, Dav M. Ebengo, Samuel V. Scarpino, Adrienne Amuri-Aziza, Tony Wawina-Bokalanga, Placide Matondo-Mbundu, Benjamin Kanku, Eddy Kinganda-Lusamaki, Jean-Claude Makangara, Daniel Mukadi-Bamuleka, Amanda Rojek, Moritz U.G. Kraemer, Christian Ngandu, Dieudonné Mwamba, Placide Mbala-Kingebeni 2026-08-06 Clinical Characteristics of Patients Infected with Bundibugyo Virus, DRC 2026 This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies. https://www.nejm.org/doi/full/10.1056/NEJMra2502459?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2502459 Theodore E. Warkentin, Andreas Greinacher 2026-07-30 Platelet-Activating Anti–Platelet Factor 4 Disorders A 37-year-old woman was evaluated for a 17-year history of unilateral nasal scabbing and bleeding. Nasal endoscopy showed marked, multifocal crusting and ulceration. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603178?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603178 Stacey T. Gray, Carolina D. Geadas, Peter M. Sadow 2026-07-30 Case 22-2026: A 37-Year-Old Woman with Persistent Nasal Ulceration Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. https://www.nejm.org/doi/full/10.1056/NEJMoa2607973?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607973 Jürgen K. Rockstroh, Moti N. Ramgopal, Adrian Curran Fàbregas, Malcolm Hedgcock, Kimberly A. Workowski, Sylvie Ronot-Bregigeon, Isabel Cassetti, Cynthia Brinson, Samir K. Gupta, Chien-Ching Hung, Mark O’Reilly, Jihad Slim, Hiroyuki Gatanaga, Peter Shalit, Shan-Yu Liu, Stephanie O. Klopfer, Fadi Shihadeh, Nidhi Patel, Reneé-Claude Mercier, Melissa Shaughnessy, Hadas Dvory-Sobol, Devi SenGupta, Cyril Llamoso, Martin S. Rhee, Chloe Orkin, the ISLEND-1 Study Team* 2026-07-29 Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment Ebola virus continues to be a global threat. In a phase 1 study, an inactivated Ebola virus vaccine was tested in healthy volunteers for safety and immunogenicity. https://www.nejm.org/doi/full/10.1056/NEJMc2518666?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518666 Tokiko Watanabe, Michiko Koga, Masanori Nojima, Minako Kono, Yuriko Tomita, Tadashi Maemura, Itsuki Anzai, Yuri Furusawa, Calvin Duong, Yoichiro Kino, Peter J. Halfmann, Fumitaka Nagamura, Hiroshi Yotsuyanagi, Yoshihiro Kawaoka 2026-07-29 iEvac-Z, an Inactivated Ebola Vaccine — Phase 1 Study in Japan Observational evidence suggests that the four-component meningococcal B vaccine (4CMenB) may reduce gonorrhea risk. In this randomized trial, 4CMenB did not result in a lower incidence of N. gonorrhoeae infection than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2516739?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516739 Kate L. Seib, Basil Donovan, Fengyi Jin, Caroline Thng, Barbara Yeung, Nicholas Comninos, Rohan I. Bopage, Anik Ray, Alison Mahony, Eric P.F. Chow, Marcus Y. Chen, Kate Maddaford, Helen Lau, Portia Westall, Dan Lu, Benjamin R Bavinton, Kathy Petoumenos, David M. Whiley, Michael P. Jennings, Amy V. Jennison, John Kaldor, Rebecca Guy, Monica M. Lahra, Jane Costello, Brent Mackie, David J. Templeton, Beng Eu, Mark O’Reilly, Christopher K. Fairley, Anna McNulty, Rick Varma, David A. Lewis, Andrew E. Grulich, the GoGoVax Study Team* 2026-07-23 Meningococcal B Vaccine to Prevent Neisseria gonorrhoeae Infection The choice of an ART regimen depends on potency, convenience, side effects, drug–drug interactions, patient factors, coexisting conditions, and access. Two- or three-drug once-daily oral regimens are recommended initially. https://www.nejm.org/doi/full/10.1056/NEJMra2511692?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2511692 Roy M. Gulick 2026-07-23 Antiretroviral Therapy The United States could take meaningful steps toward eliminating hepatitis C by broadly testing and treating people who are involved in the criminal legal system. https://www.nejm.org/doi/full/10.1056/NEJMp2602773?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602773 Josiah D. Rich, Karla Thornton, Matthew J. Akiyama 2026-07-23 National Elimination of Hepatitis C — The Case for Starting in Prisons and Jails A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules. https://www.nejm.org/doi/full/10.1056/NEJMicm2603020?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603020 Rolter Lorenz M. Lee, Bonifacio C. Pedregosa II 2026-07-23 Neurocysticercosis Well-designed observational studies are critical to advancing understanding of the effects of vaccines. But they are often dismissed as lacking the methodologic rigor necessary to inform policymaking. https://www.nejm.org/doi/full/10.1056/NEJMp2605103?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605103 Arnold S. Monto, Helen Y. Chu 2026-07-23 The Best of Both Worlds — Using Clinical Trial and Observational Data to Evaluate Vaccine Protection A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086 Aubrey L. Gilbert, Bart K. Chwalisz, Racine S. Gue, Lisa M. Bebell 2026-07-23 Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess. https://www.nejm.org/doi/full/10.1056/NEJMc2108952?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2108952 Christoph M. Ernst, Lilly K.S. Fischer, Abigail L. Manson, Li Li, Peijun Ma, Melis N. Anahtar, Roby P. Bhattacharyya, Ashlee M. Earl, Anne E. Clatworthy, Deborah T. Hung 2026-07-23 Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract Health care–associated infections remain a major cause of illness across U.S. hospitals. In this cross-sectional study, the burden of such infections is compared between 2015 and 2023 with attention to changing definitions. https://www.nejm.org/doi/full/10.1056/NEJMoa2510881?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2510881 Nora Chea, Rongxia Li, Taniece Eure, Rebecca Alkis Ramirez, Joelle Nadle, Jane E. Lee, Monica Lehmann, Lyndzie Sardenga, Christopher A. Czaja, Helen Johnston, Melissa Kellogg, Catherine Emanuel, Alana Cilwick, Maria A. Correa, Meghan Maloney, Susan M. Ray, Jessica Howard-Anderson, Stacy Carswell, Lucy E. Wilson, Rebecca Perlmutter, Kaytlynn Marceaux-Galli, J.P. Mahoehney, Ruth Lynfield, Marla Sievers, Cory Cline, Melissa Judson, Ghinwa Dumyati, Christine Hurley, Elizabeth Keller, Marissa Walsh, Erin Licherdell, Julia Tellerman, Rebecca Pierce, Valerie L.S. Ocampo, Monika E. Samper, Kimberly A. Hires, Lauren T. Adrian, Roza P. Tammer, Alexia Zhang, Shannon Hiratzka, Angela Dusko, Christopher Wilson, Melphine Harriott, Henrietta Smith, Victoria Russo, LaTasha Boswell, Dominique Godfrey, Denise Leaptrot, Marissa McMeen, Melissa Otis, Jennifer Watkins, Amber Taylor, Rita Allen, Nicola D. Thompson, Jonathan R. Edwards, Shelley S. Magill, Cheri T. Grigg 2026-07-16 Health Care–Associated Infections in U.S. Hospitals, 2023 versus 2015 This review summarizes the current state of the 2026 filovirus disease outbreak in the Democratic Republic of Congo, as well as the principles and approaches that are informing the response. https://www.nejm.org/doi/full/10.1056/NEJMra2607216?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2607216 Nancy J. Sullivan 2026-07-16 Bundibugyo Virus Disease in 2026 — Clinical and Public Health Responses A 38-year-old man was evaluated at the hospital because of postprandial abdominal pain. Six weeks earlier, a diarrheal illness had developed while he was working in Madagascar. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513544 Aima A. Ahonkhai, Howard M. Heller, Sarah M. Schrader 2026-07-16 Case 20-2026: A 38-Year-Old Man with Abdominal Pain Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed. https://www.nejm.org/doi/full/10.1056/NEJMra2606651?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2606651 Gavin H. Harris, Anabel Sinchi, James Lawler, Maria Frank 2026-07-15 Andes Virus — A Clinical Review