The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Infectious Disease. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Wed, 02 Sep 2026 22:05:49 GMT 2026 NEJM Group en-us 1440 In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-09-03 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock This review summarizes the management of pulmonary nodules, with an emphasis on nodule type, imaging follow-up, cancer risk, and strategies to balance timely diagnosis with avoidance of unnecessary procedures. https://www.nejm.org/doi/full/10.1056/NEJMcp2515063?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2515063 Matthew E.J. Callister, Gerard A. Silvestri 2026-09-03 Pulmonary Nodules A 72-year-old man presented with a 2-month history of a painful lump on his neck. Cytologic analysis of fine-needle aspirate was consistent with suppurative lymphadenopathy. The lesion subsequently ulcerated and released purulent discharge. https://www.nejm.org/doi/full/10.1056/NEJMicm2517515?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2517515 Ana Rita Ambrosio, Hugo Pego 2026-09-03 Scrofuloderma Improving the clinical treatment of patients with sepsis remains a major focus of critical care physicians worldwide.1,2 To date, few studies in either the pediatric or adult literature have established universal management principles that reliably improve outcomes, which attests to the heterogeneity of this syndrome. Fluid resuscitation is... https://www.nejm.org/doi/full/10.1056/NEJMe2609856?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609856 Michael F. O’Connor, Juliane Bubeck-Wardenburg 2026-09-03 Fluid Resuscitation in Patients with Sepsis — For Whom the Balance Tolls A new pathogenic orthonairovirus was identified in patients with a febrile illness in China. This virus was found in Haemaphysalis longicornis ticks in the same region. https://www.nejm.org/doi/full/10.1056/NEJMc2602496?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2602496 Xiao-Ai Zhang, Bo Liu, Si-Qian Wu, Xin Yang, Ning Cui, Ling Lin, Xue-Jun Wang, Nan Li, Ming Chen, Ming-Da Hu, Jun Wu, Ellen Owen, Jonathan E. Owen, Li-Qun Fang, Wei Liu 2026-09-03 A Zoonotic Orthonairovirus from Febrile Patients in China Among adults with endocarditis caused by S. aureus, E. faecalis, or streptococcus species, tailored-duration antibiotic therapy led to 13 more days alive without antibiotics than standard therapy, but with a higher incidence of relapse. https://www.nejm.org/doi/full/10.1056/NEJMoa2607887?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607887 Henning Bundgaard, Mia Pries-Heje, Julie Hjulmand, Rasmus Hasselbalch, Peter Godsk Jørgensen, Søren Fanø, Nana Køber, Christian Tuxen, Nareen Kader, Ekim Seven, Lars Ege Rasmussen, Malene Wienberg, Niels Eske Bruun, Marlene Tofterup, Magnus Rasmussen, Lindsey R. Baden, Ann Woolley, Theis Lange, Jannik Helweg-Larsen, Jonas Agerlund Povlsen, Emil Fosbøl, Claus Moser, Kasper Iversen, the POET II Investigators* 2026-08-28 Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603179?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603179 Pierre O. Ankomah, Cynthia L. Czawlytko, Joseph B. El Khoury, Stefen Andrianus, M. Lauren Donnelly-Morell 2026-08-20 Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia An 82-year-old man was brought to the ED after being “found down.” One week earlier, he had returned from a 1-month visit to Chad. A peripheral-blood smear showed ring-form trophozoites within erythrocytes. https://www.nejm.org/doi/full/10.1056/NEJMicm2603855?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603855 Emilie Karoline Van Pee, Johan Van Laethem 2026-08-20 Severe Plasmodium falciparum Malaria A 61-year-old man with prolonged neutropenia after chemotherapy for AML was evaluated for persistent fever despite antimicrobial therapy. Physical examination was notable for a skin macule with central necrosis on the chest. https://www.nejm.org/doi/full/10.1056/NEJMicm2603271?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603271 Hanna Osawa, Takahisa Fujino 2026-08-13 Disseminated Fusariosis Without deliberate efforts to evaluate long-acting injectable ART in the populations that need these therapies most, their benefits may accrue primarily to people who are well served by existing systems. https://www.nejm.org/doi/full/10.1056/NEJMp2605547?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605547 Jonathan Falconer, Linda-Gail Bekker, Joseph N. Jarvis 2026-08-13 Long-Acting Treatment and Advanced HIV Disease — Addressing a Public Health Priority Ebola virus continues to be a global threat. In a phase 1 study, an inactivated Ebola virus vaccine was tested in healthy volunteers for safety and immunogenicity. https://www.nejm.org/doi/full/10.1056/NEJMc2518666?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518666 Tokiko Watanabe, Michiko Koga, Masanori Nojima, Minako Kono, Yuriko Tomita, Tadashi Maemura, Itsuki Anzai, Yuri Furusawa, Calvin Duong, Yoichiro Kino, Peter J. Halfmann, Fumitaka Nagamura, Hiroshi Yotsuyanagi, Yoshihiro Kawaoka 2026-08-13 iEvac-Z, an Inactivated Ebola Vaccine — Phase 1 Study in Japan In South Carolina, 997 measles cases occurred in the reported outbreak. In one health care system, 81 cases were identified. Most were in unvaccinated persons; 13 persons were hospitalized, and 2 had measles encephalitis. https://www.nejm.org/doi/full/10.1056/NEJMc2605131?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2605131 Katherine M. Richardson, Johnathon Elkes, Claudia Nieuwoudt, Jonathan Markowitz, Robin Lacroix 2026-08-13 A Regional Measles Outbreak — South Carolina, 2025–2026 The lack of vaccines and disease-specific therapeutics for Bundibugyo Ebola has dramatically affected the community’s perception of Ebola treatment centers. In this context, trust becomes critical. https://www.nejm.org/doi/full/10.1056/NEJMp2607429?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607429 Serge Tonen-Wolyec, Laurent Bélec 2026-08-06 The Social Contract of Bundibugyo Ebola Isolation An accurate history of Ebola begins with partnerships, including those between responders and the populations they serve. One of its key lessons is that equity must be integral to outbreak preparedness. https://www.nejm.org/doi/full/10.1056/NEJMp2607819?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607819 Alimuddin Zumla, Francine Ntoumi, Nicaise Ndembi, Sabue Mulangu, Peter Piot, Jean-Jacques Muyembe-Tamfum, Jean B. Nachega 2026-08-06 Ebola at 50 — Lessons for Outbreak Response and Preparedness Increasing pandemic frequency and increasing economic inequality are creating a self-reinforcing cycle. What’s needed is therefore a new, inequality-informed approach to pandemic preparedness. https://www.nejm.org/doi/full/10.1056/NEJMp2607839?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607839 Matthew M. Kavanagh, Joseph E. Stiglitz, Monica Geingos, Winnie Byanyima, Michael G. Marmot, the Global Council on Inequality, AIDS, and Pandemics 2026-08-06 The Inequality–Pandemic Cycle — Rethinking Preparedness The Bundibugyo virus outbreak in the DRC and Uganda has focused concern on potential countermeasures. Investigators assessed cross-reactive immune responses in serum obtained during previous Ebola vaccine trials. https://www.nejm.org/doi/full/10.1056/NEJMc2608018?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2608018 Edouard Lhomme, Aurélie Wiedemann, Ahidjo Ayouba, Safaa Ben-Farhat, Guillaume Thaurignac, Céline Roy, Abdoul Habib Beavogui, Seydou Doumbia, Mark Kieh, Bailah Leigh, Samba Sow, Stephen A. Migueles, Deborah Watson-Jones, Yazdan Yazdanpanah, Rodolphe Thiébaut, Martine Peeters, Laura Richert, Yves Levy, for the PREVAC Study Team* 2026-08-06 Cross-Reactive Bundibugyo Antibody Responses after Receipt of Licensed Ebola Vaccines Bundibugyo virus, a filovirus, is currently spreading in the Democratic Republic of Congo. This report presents early data on symptoms and illness severity as well as diagnostic challenges. https://www.nejm.org/doi/full/10.1056/NEJMc2608070?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2608070 Pierre Akilimali, Dav M. Ebengo, Samuel V. Scarpino, Adrienne Amuri-Aziza, Tony Wawina-Bokalanga, Placide Matondo-Mbundu, Benjamin Kanku, Eddy Kinganda-Lusamaki, Jean-Claude Makangara, Daniel Mukadi-Bamuleka, Amanda Rojek, Moritz U.G. Kraemer, Christian Ngandu, Dieudonné Mwamba, Placide Mbala-Kingebeni 2026-08-06 Clinical Characteristics of Patients Infected with Bundibugyo Virus, DRC 2026 This review summarizes platelet-activating anti–platelet factor 4 disorders, including heparin-induced thrombocytopenia and related syndromes, highlighting diagnosis, antibody mechanisms, and treatment strategies. https://www.nejm.org/doi/full/10.1056/NEJMra2502459?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2502459 Theodore E. Warkentin, Andreas Greinacher 2026-07-30 Platelet-Activating Anti–Platelet Factor 4 Disorders A 37-year-old woman was evaluated for a 17-year history of unilateral nasal scabbing and bleeding. Nasal endoscopy showed marked, multifocal crusting and ulceration. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603178?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603178 Stacey T. Gray, Carolina D. Geadas, Peter M. Sadow 2026-07-30 Case 22-2026: A 37-Year-Old Woman with Persistent Nasal Ulceration Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. https://www.nejm.org/doi/full/10.1056/NEJMoa2607973?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607973 Jürgen K. Rockstroh, Moti N. Ramgopal, Adrian Curran Fàbregas, Malcolm Hedgcock, Kimberly A. Workowski, Sylvie Ronot-Bregigeon, Isabel Cassetti, Cynthia Brinson, Samir K. Gupta, Chien-Ching Hung, Mark O’Reilly, Jihad Slim, Hiroyuki Gatanaga, Peter Shalit, Shan-Yu Liu, Stephanie O. Klopfer, Fadi Shihadeh, Nidhi Patel, Reneé-Claude Mercier, Melissa Shaughnessy, Hadas Dvory-Sobol, Devi SenGupta, Cyril Llamoso, Martin S. Rhee, Chloe Orkin, the ISLEND-1 Study Team* 2026-07-29 Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment