The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Infectious Disease. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sun, 18 Oct 2026 22:47:17 GMT 2026 NEJM Group en-us 1440 A 36-year-old woman presented with a 6-year history of gradually worsening low back pain and intermittent night sweats. On examination, she had a sharp, kyphotic angulation of the lower spine. https://www.nejm.org/doi/full/10.1056/NEJMicm2607513?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2607513 Sara Pereira Henriques, Margarida Mota 2026-10-17 Spinal Tuberculosis Trust is the precondition for informed consent, shared decision making, and any clinical intervention. But public trust in medicine is rapidly eroding, and it can’t be rebuilt in a single policy cycle. https://www.nejm.org/doi/full/10.1056/NEJMp2604584?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2604584 Robert B. Shpiner 2026-10-17 What I See before Anyone Speaks Full adherence to daily antiretroviral therapy for HIV can be challenging. In this phase 3b trial in Kenya, South Africa, and Uganda, a long-acting ART regimen was noninferior to daily ART use. https://www.nejm.org/doi/full/10.1056/NEJMoa2518753?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2518753 Fiona V. Cresswell, Jonathan Kitonsa, Claire Norcross, Victoria Tumusiime, Loice Achieng Ombajo, Nigel Garrett, Sheetal Kassim, Noela C. Owarwo, Eva A. Laker Odongpiny, Ibrahim Yawe, Sharana Mahomed, Henry Mugerwa, Paddy L. Kafeero, Joseph Nkuranga, Ubaldo Bahemuka, Jane Nabbuto, Violet Ankunda, Phiona Nabaggala, Charles Ogwang, Geofrey Kimbugwe, Ayoub Kakande, Upasna Singh, Dorothie van der Vendt, Arnold Onyango, Eve Koile, David S. Lawrence, Awhonukeh Idahosa, Veerle van Eygen, Fafa Addo Boateng, Ingrid Eshun-Wilsonova, Daniel J. Grint, Eugene Ruzagira, the IMPALA Study Group* 2026-10-15 Long-Acting HIV Therapy in African Adults with Adherence Challenges An antiviral therapy has not been approved for dengue. In this report, mosnodenvir, a small-molecule antiviral, was shown to be protective in a human challenge model of dengue, and a weekly regimen provided adequate blood levels. https://www.nejm.org/doi/full/10.1056/NEJMc2516395?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2516395 Liesbeth Van Wesenbeeck, Freya Rasschaert, Kristen K. Pierce, Guillermo Herrera-Taracena, Beulah P. Sabundayo, Annemie Buelens, Patricia Lutton, Veerle Van Eygen, Megan McKnight, Kim De Clerck, Isabel Fetter, Xi Fang, Nele Goeyvaerts, Kathleen Callewaert, Sarah Sampson, Jeffrey Mayfield, Oliver Lenz, Sandra De Meyer, Thomas N. Kakuda, Helen He, Emérito Amaro-Carambot, Ruxandra Draghia-Akli, Marya Carmolli, Marnix Van Loock, Stephen S. Whitehead, Anna P. Durbin 2026-10-15 Once-Weekly Mosnodenvir as Dengue Prophylaxis in a Human Infection Model Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors. https://www.nejm.org/doi/full/10.1056/NEJMoa2516225?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516225 The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network 2026-10-08 Vasopressors or Fluids in Early Septic Shock A 35-year-old woman presented with a 20-day history of a nipple ulcer. On examination, there was ulceration, crusting, and a yellowish exudate on the right nipple. https://www.nejm.org/doi/full/10.1056/NEJMicm2605910?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2605910 Yangbin Wang, Chun-Fang Guo 2026-10-08 Syphilitic Chancre on the Nipple When public health measures conflict with cultural, relational, and emotional practices surrounding severe illness and death, they may lead to uprisings that increase the risk of infection spread. https://www.nejm.org/doi/full/10.1056/NEJMp2608136?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2608136 Celestin Mutuyimana, Clare Killikelly 2026-10-08 Grief as a Vector for Disease — Tradition and Public Health in Ebola Outbreaks Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in... https://www.nejm.org/doi/full/10.1056/NEJMe2609170?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609170 Theodore J. Iwashyna 2026-10-08 More Than One Way to Save a Life in Septic Shock A 19-year-old woman presented with fever and cervical lymphadenopathy. The white-cell count was 2900 per microliter (reference range, 4000 to 11,000), and the lactate dehydrogenase level was elevated. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603182?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603182 Ezra M. Cohen, Shohei Fujita, Daniel R. Brown, Vanda F. Torous 2026-10-08 Case 28-2026: A 19-Year-Old Woman with Fever, Cervical Lymphadenopathy, and Leukopenia Pedro Sánchez and Tedros Adhanom Ghebreyesus reflect on the management of Andes hantavirus and the way in which careful, coordinated outbreak response can limit risk without undermining dignity. https://www.nejm.org/doi/full/10.1056/NEJMp2611801?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2611801 Pedro Sánchez, Tedros Adhanom Ghebreyesus 2026-10-08 Hantavirus — Lessons Learned about Security and Solidarity Among patients with HIV-1 suppression while receiving bictegravir–emtricitabine–tenofovir alafenamide (B/F/TAF), switching to weekly islatravir–lenacapavir was noninferior to continuing daily B/F/TAF in maintaining suppression. https://www.nejm.org/doi/full/10.1056/NEJMoa2607973?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607973 Jürgen K. Rockstroh, Moti N. Ramgopal, Adrian Curran Fàbregas, Malcolm Hedgcock, Kimberly A. Workowski, Sylvie Ronot-Bregigeon, Isabel Cassetti, Cynthia Brinson, Samir K. Gupta, Chien-Ching Hung, Mark O’Reilly, Jihad Slim, Hiroyuki Gatanaga, Peter Shalit, Shan-Yu Liu, Stephanie O. Klopfer, Fadi Shihadeh, Nidhi Patel, Reneé-Claude Mercier, Melissa Shaughnessy, Hadas Dvory-Sobol, Devi SenGupta, Cyril Llamoso, Martin S. Rhee, Chloe Orkin, the ISLEND-1 Study Team* 2026-10-01 Phase 3 Trial of Weekly Oral Islatravir–Lenacapavir for HIV-1 Treatment Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed. https://www.nejm.org/doi/full/10.1056/NEJMra2606651?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2606651 Gavin H. Harris, Anabel Sinchi, James Lawler, Maria Frank 2026-10-01 Andes Virus — A Clinical Review A 58-year-old woman with previously stable hearing impairment was admitted for rapidly progressive bilateral hearing loss. She reported no headache, vertigo, tinnitus, or dizziness. https://www.nejm.org/doi/full/10.1056/NEJMcps2600385?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcps2600385 Roni Eichel, Gabriel S. Breuer, Eyal Ben Dori, Merav Weil, Eli Ben-Chetrit 2026-10-01 An Echo Unheard The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside. https://www.nejm.org/doi/full/10.1056/NEJMp2605442?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605442 David Blumenthal, James A. Morone 2026-09-24 The End of the War on Biomedical Science? A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. https://www.nejm.org/doi/full/10.1056/NEJMicm2609443?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2609443 Mary-France G. Lebii, Bonifacio C. Pedregosa II 2026-09-24 Cerebral Schistosomiasis Oya virus, an orthobunyavirus, was identified in a 54-year-old woman who had sepsis-like symptoms, including leukocytosis, thrombocytopenia, elevated liver-function values, and disseminated intravascular coagulation. https://www.nejm.org/doi/full/10.1056/NEJMc2602616?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2602616 Yulong Wang, Linjin Fan, Zhipeng Zhang, Xudan Chen, Yiwen Chen, Yang Zhou, Jingcheng Wu, Pengfei Ye, Jicheng Huang, Jun Dai, Jiahao Lin, Pinfu Lai, Jian Wang, Sisi Liu, Yihui Huang, Linghua Li, Hongbing Jiang, Jun Qian, Linna Liu 2026-09-24 Oya Virus in a Patient with Severe Hepatitis, Enteritis, and Coagulopathy Progress against the U.S. HIV epidemic is stalling, owing in part to government attacks and fear. But clinicians, patients, and activists can learn from the epidemic’s early heroes and find ways to advance. https://www.nejm.org/doi/full/10.1056/NEJMp2601860?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601860 Ofole Mgbako 2026-09-17 Honoring the Legacy of the HIV Epidemic Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease. https://www.nejm.org/doi/full/10.1056/NEJMc2605960?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2605960 Christian Irsara, Habib Benainouna, Jing Jing Wang, Andrea Griesmacher, Christoph Winkler, Lorin Loacker, Markus Anliker, Xiaoyan Wang, Alex Moser, Thomas Müller, Werner Streif, Andreas Greinacher, Thomas Thiele, Wibke Bayer, Linda Schönborn 2026-09-17 Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis In a randomized trial involving adults who received local antibiotics during surgery for orthopedic infection, a short duration of systemic antibiotics was noninferior to a long duration regarding treatment failure at 12 months. https://www.nejm.org/doi/full/10.1056/NEJMoa2506756?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2506756 Martin McNally, Maria Dudareva, Michelle Kümin, Werner Vach, Claire L. Scarborough, Matthew J. Cichero, Ricardo Sousa, Jamie Ferguson, David A. Stubbs, Bridget L. Atkins, Alex J. Ramsden, Bernadette C. Young, Andre D. Carvalho, Adrian R. Kendal, Abtin Alvand, Antony J.R. Palmer, Con L. Loizou, Ben Kendrick, Adrian H. Taylor, Amirul Islam, Michael J. Riste, Anand Pillai, Sunil K. Sharma, Jonathan Folb, Neal Jacobs, Simon C. Ellis, Aaron B.Y. Ng, Daniel Perez-Prieto, Irene K. Sigmund, Reinhard Windhager, Alexis D. Iliadis, Andrew J.F. Bing, Henry Wynn Jones, John Williams, Ben J. Ollivere, Volker Alt, Simon Warren, Neil E. Jenkins, Andreas Leithner, Harriet C. Hughes, Steve A. Jones, O. Martin Williams, Matthew Scarborough 2026-09-16 Short or Long Antibiotic Regimens in Orthopedics A 65-year-old man was admitted to this hospital because of fever, intermittent abdominal pain, and rash. The fever began 5 weeks earlier, and palpable purpura developed 1 week before admission. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517855?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517855 Jacqueline T. Chu, Robert G. Rasmussen, Jacquelyn M. Nestor, Mack Y. Su 2026-09-10 Case 25-2026: A 65-Year-Old Man with Fever and Rash