The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology/Neurosurgery. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Mon, 10 Aug 2026 09:41:02 GMT 2026 NEJM Group en-us 1440 As the health of his brother and running buddy rapidly declines and he faces his own health scares, a physician feels compelled — and grateful — to keep moving forward. https://www.nejm.org/doi/full/10.1056/NEJMp2518293?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2518293 James T. Rosenbaum 2026-08-08 Last Man Running Among patients who were unresponsive after cardiac arrest, conservative oxygen therapy did not increase 180-day survival with favorable function as compared with liberal oxygen therapy. https://www.nejm.org/doi/full/10.1056/NEJMoa2513814?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513814 The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group 2026-08-06 Conservative Oxygen for Unresponsive Patients after Cardiac Arrest This review summarizes the classification, evaluation, risk stratification, and management of syncope. History, examination, electrocardiography, and orthostatic blood-pressure measurement identify the cause in most patients. https://www.nejm.org/doi/full/10.1056/NEJMcp2517255?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2517255 Rose Anne Kenny 2026-08-06 Syncope In unresponsive patients after cardiac arrest, a complex pathophysiological response including potential brain injury, myocardial dysfunction, and systemic ischemia–reperfusion injury is at play, in addition to the challenges of the underlying cause of cardiac arrest.1 This complex and unique, but heterogeneous, constellation has prompted clinicians and researchers to... https://www.nejm.org/doi/full/10.1056/NEJMe2609084?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609084 Lars W. Andersen, Asger Granfeldt 2026-08-06 Oxygen Targets after Cardiac Arrest — A LOGICAL Finding In a patient with Duchenne muscular dystrophy, cardiotoxic effects developed after treatment with delandistrogene moxeparvovec. Microdystrophin levels in the heart and skeletal muscle were less than 1% of normal dystrophin levels. https://www.nejm.org/doi/full/10.1056/NEJMc2518477?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518477 Benjamin J. Samelson-Jones, Cristina Martos-Rus, Carolyn M. Yrigollen, Luis Tecedor, Juliana C. Small, Susan E. Matesanz, Connor T. Watson, Andrew R. Vanden Heuvel, Sean Carrig, Sabrina W. Yum, John F. Brandsema, Kimberly Lin, Carol Wittlieb-Weber, Angela N. Viaene, Pierre P. Russo, Sara Partington, Katie Huynh, Tiffany Seneviratne, Silvia Juarez Rojas, Bhavya S. Doshi, Perry Shieh, Kevin M. Flanigan, Emma Frair, Stefan Nicolau, Michael W. Lawlor, Julie M. Crudele, Beverly L. Davidson, Lindsey A. George 2026-08-06 Cardiotoxic Effects and Microdystrophin Expression after Gene Therapy for DMD The selective NaV1.8 inhibitor LTG-001 led to significantly greater reductions in pain scores than placebo over the course of 48 hours among patients who had moderate or severe pain after abdominoplasty. https://www.nejm.org/doi/full/10.1056/NEJMoa2602910?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2602910 Neil Singla, Nathaniel P. Katz, Ben Vaughn, Timothy Rogier, Todd Bertoch, Harold Minkowitz, Mallory Loflin 2026-07-30 Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain When a patient receives a diagnosis of amyotrophic lateral sclerosis, he is shocked. But he’s also dubious enough to seek a second opinion. https://www.nejm.org/doi/full/10.1056/NEJMp2517208?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2517208 Brendan M. Reilly 2026-07-30 Braking Bad News This study supports enzymatic cross-correction of neurons and oligodendrocytes by atidarsagene autotemcel, a gene therapy that prevents or slows neurodegeneration in children with early-onset metachromatic leukodystrophy. https://www.nejm.org/doi/full/10.1056/NEJMc2505002?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2505002 Vasco Meneghini, Valeria Calbi, Filippo Casalini, Elisabeth Mangiameli, Francesco Morena, Marco Piccoli, Ilaria Laface, Ilaria Rossomanno, Francesca Ornaghi, Andrea Ghiroldi, Paola M.V. Rancoita, Francesca Fumagalli, Sabata Martino, Luigi Anastasia, Luigi Naldini, Alessandro Aiuti, Angela Gritti 2026-07-30 Cross-Correction in HSC Gene Therapy for Metachromatic Leukodystrophy A 52-year-old woman presented with a 4-month history of headache and visual hallucinations. MRI of the brain showed cystic lesions containing bright nodules. https://www.nejm.org/doi/full/10.1056/NEJMicm2603020?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2603020 Rolter Lorenz M. Lee, Bonifacio C. Pedregosa II 2026-07-23 Neurocysticercosis A 28-year-old man was admitted to the hospital because of monocular vision loss. Examination showed optic disk edema, and imaging revealed liver lesions and lymphadenopathy. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2518086 Aubrey L. Gilbert, Bart K. Chwalisz, Racine S. Gue, Lisa M. Bebell 2026-07-23 Case 21-2026: A 28-Year-Old Man with Headache and Vision Loss in the Right Eye In a patient with a staghorn calculus, chronic urinary tract infection with Klebsiella pneumoniae enabled within-patient evolution of virulence properties that facilitated dissemination of infection, leading to a brain abscess. https://www.nejm.org/doi/full/10.1056/NEJMc2108952?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2108952 Christoph M. Ernst, Lilly K.S. Fischer, Abigail L. Manson, Li Li, Peijun Ma, Melis N. Anahtar, Roby P. Bhattacharyya, Ashlee M. Earl, Anne E. Clatworthy, Deborah T. Hung 2026-07-23 Klebsiella Brain Abscess and Evolution of Heterovirulence in the Urinary Tract Fibromyalgia is associated with widespread pain, sleep difficulty, fatigue, and cognitive symptoms. Treatment includes education and nonpharmacologic interventions; selected drugs may help, but opioid agents are not recommended. https://www.nejm.org/doi/full/10.1056/NEJMcp2411656?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2411656 David A. Williams, Daniel J. Clauw 2026-07-16 Fibromyalgia Medication management in autism requires clinicians to navigate uncertainty while respecting the experiences of autistic people and their families. Shared decision making can be a helpful approach. https://www.nejm.org/doi/full/10.1056/NEJMp2602649?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2602649 Yaara Zisman-Ilani, Ron Walfisch, Jeremy Veenstra-VanderWeele, David S. Mandell 2026-07-16 Pharmacotherapeutic Decisions in Autism As his physician-father’s neurologic health suddenly deteriorates, a physician-son takes notes. With his usual compartmentalization failing him, he knows he can at least bear witness to his father’s decline. https://www.nejm.org/doi/full/10.1056/NEJMp2516621?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516621 Steven McGaughey 2026-07-16 The Symptom Tracker A 21-year-old man had measles after allogeneic stem-cell transplantation complicated by graft-versus-host disease. After he had recovered from the acute infection, an encephalitis developed that was ultimately fatal. https://www.nejm.org/doi/full/10.1056/NEJMc2511896?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2511896 Benjamin Nemoz, Meriadeg Ar Gouilh, Karin Pernet-Gallay, Anais Dartevel, Jean Boutonnat, Cyrille Mathieu, Sylvie Berthier, Denis Gerlier, Bryce Leterrier, Anne Thiébaut, Patrice Morand, Julien Lupo, Olivier Epaulard 2026-07-09 Measles Inclusion-Body Encephalitis after Allogeneic Stem-Cell Transplantation Among patients with newly diagnosed relapsing multiple sclerosis, rituximab was noninferior to ocrelizumab in preventing new or enlarging lesions on MRI. The risk of serious adverse events was similar in the two groups. https://www.nejm.org/doi/full/10.1056/NEJMoa2600993?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600993 Øivind Torkildsen, Hilde Kjelgaard Brustad, Einar August Høgestøl, Karl Bjørnar Alstadhaug, Alok Bhan, Heidi Øyen Flemmen, Andrea Habbestad, Rune A.A. Høglund, Marissa LeBlanc, Peter Lopen, Åslaug Rudjord Lorentzen, Åse Hagen Morsund, Andreas Lossius, Rigmor Lundby, Gro O. Nygaard, Brit Ellen Rød, Cecilia Smith Simonsen, Linn Steffensen, Hilde Torgauten, Fredrik Piehl, Stig Wergeland, Kjell-Morten Myhr, the OVERLORD-MS Investigators* 2026-07-02 Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis This review summarizes advances in the treatment of multiple sclerosis, with emphasis on effective disease-modifying therapies for relapsing disease and the need for better treatments to prevent progression and rebuild myelin. https://www.nejm.org/doi/full/10.1056/NEJMra2501195?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2501195 Stephen L. Hauser 2026-07-02 Advances in Multiple Sclerosis A 56-year-old woman was hospitalized with gait instability. Eight weeks earlier, she had noticed ascending symmetric sensations of painful “pins and needles” that had begun in her feet; she later had memory impairment and irritability. https://www.nejm.org/doi/full/10.1056/NEJMcps2517160?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcps2517160 Jasdeep Singh Bajwa, Gurpreet Dhaliwal, Reza Manesh, Sandesh Rao 2026-07-02 The Daily Grind Pain interferes with daily activities and undermines people’s ability to engage in treatment for opioid use disorder. Yet barriers to assessment and treatment of pain persist. https://www.nejm.org/doi/full/10.1056/NEJMp2601411?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601411 Zu-In Su, Carlos Blanco, Tisha Wiley, Nora D. Volkow 2026-07-02 Opportunities to Combat the Chronic Pain–Opioid Use Disorder Syndemic Patients with shrinking cognitive bandwidth may feel their disability keenly in daily life, even if they can pass a controlled test of cognitive capacity. How should clinicians approach and care for them? https://www.nejm.org/doi/full/10.1056/NEJMp2600769?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600769 Jan Stubberud 2026-07-02 The Invisible Load of Cognitive Symptoms