The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology/Neurosurgery. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Mon, 08 Jun 2026 01:39:42 GMT 2026 NEJM Group en-us 1440 Despite recognition that racial and ethnic categories are poor proxies for genetic diversity, race is still used to guide pharmaceutical use, posing risks of ineffectively low or dangerously high dosing. https://www.nejm.org/doi/full/10.1056/NEJMp2516090?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516090 Harsimar K. Ahuja, David S. Jones, Winfred W. Williams 2026-06-06 Prescription without Precision — Dangers of Dosing on the Basis of Race as Biology A neuroepithelial tumor occurred in a child who had previously received AAV gene therapy for mucopolysaccharidosis type I. Analysis of tumor tissue showed the integration of rearranged AAV vector elements in the gene PLAG1. https://www.nejm.org/doi/full/10.1056/NEJMoa2601608?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601608 Rebecca C. Ahrens-Nicklas, Chelsea Kotch, Aoife M. Roche, John K. Everett, Shantan Reddy, Mariarita Santi, Peter J. Madsen, Cristina Martos-Rus, Carolyn M. Yrigollen, Juliana C. Small, Sarah McCague, Beverly L. Davidson, Benjamin J. Samelson-Jones, Lea F. Surrey, Marilyn Li, Can Ficicioglu, Raymond Wang, Frederic D. Bushman, Lindsey A. George 2026-06-04 Brief Report: Neuroepithelial Tumor with AAV Integration after Intracisternal Magna Vector Delivery Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to... https://www.nejm.org/doi/full/10.1056/NEJMe2605851?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2605851 Yoshiya Tanaka 2026-06-03 Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting In a trial involving children with Chiari type I malformation and syringomyelia, the percentage with surgical complications did not differ significantly between posterior fossa decompression with duraplasty and decompression alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2402821?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2402821 David D. Limbrick Jr., Chevis N. Shannon, Emine O. Bayman, Thanda Meehan, Marisa Kallem, Laurie L. Ackerman, P. David Adelson, Raheel Ahmed, Gregory Albert, Philipp R. Aldana, Tord D. Alden, Richard C.E. Anderson, Lissa C. Baird, David Bauer, Tammy Bethel-Anderson, Karin Bierbrauer, Douglas L. Brockmeyer, Joshua J. Chern, Daniel E. Couture, David J. Daniels, Robert C. Dauser, Brian J. Dlouhy, Susan R. Durham, Richard G. Ellenbogen, Ramin Eskandari, Stephen R. Gannon, Gerald A. Grant, Patrick C. Graupman, Jacob K. Greenberg, Stephanie Greene, Jeffrey P. Greenfield, Naina L. Gross, Daniel J. Guillaume, Todd C. Hankinson, Gregory Heuer, Mark Iantosca, Bermans J. Iskandar, Eric M. Jackson, George I. Jallo, James M. Johnston, Robert F. Keating, Michael P. Kelly, Elaine Kennedy, Mark D. Krieger, Abhaya V. Kulkarni, Rick Labuda, Jeffrey R. Leonard, Cormac O. Maher, Francesco T. Mangano, J. Gordon McComb, Sean D. McEvoy, Robert C. McKinstry, Arnold H. Menezes, Toba N. Niazi, Jerry Oakes, Greg Olavarria, Brent R. O’Neill, Dorothy Poppe, John Ragheb, Samuel Reeves, Lisa Reynolds, Nathan R. Selden, Manish N. Shah, Joshua S. Shimony, Matthew D. Smyth, Sandy Spears, Scellig S.D. Stone, Jennifer M. Strahle, Mandeep Tamber, Gina Tramelli, Gerald F. Tuite, Elizabeth C. Tyler-Kabara, Haley Vance, Scott D. Wait, John C. Wellons III, William E. Whitehead, Alexander T. Yahanda, Yan Yan, Ralph G. Dacey Jr., Tae Sung Park, James C. Torner, the Park-Reeves Syringomyelia Research Consortium Investigators 2026-05-28 Decompression with or without Duraplasty for Chiari I and Syringomyelia After a physician pronounces his 15-year-old patient dead over the phone, he respects her parents’ silence, though it leaves him isolated in his grief and craving some form of closure. https://www.nejm.org/doi/full/10.1056/NEJMp2513303?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2513303 James A. Feinstein 2026-05-28 When Closure Finds You A 64-year-old woman presented with fatigue, memory changes, and falls. MRI of the head revealed numerous hyperintense foci in the white matter on fluid-attenuated inversion recovery images. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517865?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517865 Shamik Bhattacharyya, Samuel C.D. Cartmell, Albert Y. Hung, Philippe A. Bilodeau, Elizabeth C. Conner 2026-05-28 Case 15-2026: A 64-Year-Old Woman with Fatigue, Memory Changes, and Falls Two patients with inborn errors of immunity and progressive multifocal leukoencephalopathy received polyomavirus-specific T cells, followed by allogeneic hematopoietic transplantation with good neurologic outcomes. https://www.nejm.org/doi/full/10.1056/NEJMc2514186?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2514186 Corina E. Gonzalez, Anita Fletcher, Tonya L. Jenkins, Sara Zahraeifard, Rose Peterson, Milo Taylor, Christine Jones, Amanda Urban, Daniele Avila, Mauricio Campillay, Jamie Wilhelm, Ariane Soldatos, Jens Kuhle, Poorva Jain, Sydney Corey, Jenna R.E. Bergerson, Daniel S. Reich, Steven Highfill, David Stroncek, Anh Dinh, Stefania Pittaluga, Heidi H. Kong, Helen C. Su, Luigi D. Notarangelo, Sung-Yun Pai, Michael Grimley, Alexandra F. Freeman, Irene Cortese 2026-05-28 Resolution of PML after Treatment with Virus-Specific T Cells and HCT Among patients with stroke due to medium-vessel occlusion, thrombectomy led to functional independence at 90 days (in 58.6% of patients, vs. 46.6% with medical management) but also to a higher risk of intracranial hemorrhage. https://www.nejm.org/doi/full/10.1056/NEJMoa2514120?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2514120 Wei Hu, Xiaozhong Jing, Zhongjun Chen, Jin Zheng, Tingyu Yi, Tuanyuan Zheng, Zhide Li, Junzhong Liu, Tao Cui, Jianshang Wen, Ganghua Feng, Cunfeng Song, Lei Yang, Shunfu Jiang, Lin Tong, Changchun Jiang, Zhongfan Ruan, ˒Peiyang Zhou, Shouchun Wang, Tao Wang, Zhiming Zhou, Youquan Ren, Tao Qiu, Chong Zheng, Hao Wang, Yong Liu, Yun Luo, Jing Wang, Zhengfei Ma, Bin Mei, Yong Liang, Yuyou Zhu, Rui Li, Jun Sun, Li Wang, Chao Zhang, Tianlong Liu, Jianlong Song, Chunrong Tao, Anmo Wang, Jinjing Wang, Pengfei Xu, Xiaofan Guo, Liqi Shu, Adnan I. Qureshi, Thanh N. Nguyen, Mohamad AbdalKader, Jeffrey L. Saver, Wenhuo Chen, Raul G. Nogueira 2026-05-14 Endovascular Treatment of Medium-Vessel-Occlusion Strokes In a trial of brepocitinib in adults with dermatomyositis, the 30-mg dose (but not the 15-mg dose) led to greater improvement on a composite myositis index at 52 weeks than placebo. Serious infections were more frequent with the 30-mg dose. https://www.nejm.org/doi/full/10.1056/NEJMoa2503531?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2503531 Ruth Ann Vleugels, Julie J. Paik, Iazsmin Bauer Ventura, Aaron R. Mangold, Prateek C. Gandiga, Anna Haemel, Hector Chinoy, Yessar M. Hussain, Kumaraswamy Sivakumar, Zoltan Griger, Eun Bong Lee, Francisca Bozan, Chung-Yuan Hsu, Alisa Femia, Mazen M. Dimachkie, Michelle S. Min, Tahseen Mozaffar, Christina Charles-Schoeman, David R. Fernandez, Oluwakemi Onajin, Raquel Campanilho-Marques, Galina Marder, Floranne Ernste, Elena Schiopu, Jason Sluzevich, David Pearson, Stephen Lindsey, Michael Luggen, Michael R. Bubb, Erin Boh, Rashmi Maganti, Latisha Heinlen, Katharina S. Shaw, Matthew D. Cascino, Paul N. Mudd Jr., Jiri Vencovsky, Anthony P. Fernandez, David Fiorentino, Lisa Christopher-Stine, Victoria P. Werth, Rohit Aggarwal, the VALOR Investigators* 2026-05-14 A Phase 3 Trial of Brepocitinib in Dermatomyositis Inflammatory myopathies are typically associated with a myositis-specific autoantibody that determines the diagnosis and prognosis. Myositis subgroups have distinct pathomechanisms that now allow for targeted therapies. https://www.nejm.org/doi/full/10.1056/NEJMra2415426?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2415426 Yves Allenbach, Olivier Benveniste 2026-05-14 Inflammatory Myopathies A 50-year-old man presented to the ED with a 1-month history of headache and worsening weakness of the left arm and leg. Brain MRI showed an enhancing lesion with extensive surrounding edema. https://www.nejm.org/doi/full/10.1056/NEJMicm2518333?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2518333 Ke Xiao, Ying Si 2026-05-14 Cerebral Syphilitic Gumma Dermatomyositis is a subgroup of idiopathic inflammatory myopathies — systemic autoimmune disorders that are typically characterized by the involvement of multiple organs, including muscle, skin, joints, lungs, gastrointestinal tract, and heart — all conditions with high morbidity and mortality.1 Treatment of myositis is based on off-label use of... https://www.nejm.org/doi/full/10.1056/NEJMe2604009?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2604009 Ingrid E. Lundberg 2026-05-14 A Phase 3 Trial of Brepocitinib in Dermatomyositis One way to classify acute ischemic stroke is by the anatomy of vessel occlusion. Initial randomized trials of endovascular thrombectomy focused on large-vessel occlusions.1-5 These proximal occlusions of the intracranial carotid artery or the stem of the middle cerebral artery (MCA) represent the most severe form of anterior... https://www.nejm.org/doi/full/10.1056/NEJMe2601852?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2601852 Johanna M. Ospel, Michael D. Hill 2026-05-14 Endovascular Therapy for Medium-Vessel Occlusion Stroke — Narrowing the Target Population Cerebral amyloid angiopathy, caused by beta-amyloid deposition in brain blood vessels, leads to lobar cerebral hemorrhage, microbleeds, and white-matter lesions and contributes to cognitive decline. https://www.nejm.org/doi/full/10.1056/NEJMra2411298?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2411298 Steven M. Greenberg 2026-05-07 Cerebral Amyloid Angiopathy An 86-year-old man presented to the neurology clinic with 2 years of progressive memory loss and difficulty walking. An MRI showed microbleeds that appeared as hypointense foci throughout the lobar regions. https://www.nejm.org/doi/full/10.1056/NEJMicm2511044?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2511044 Sihui Chen, Xueping Chen 2026-05-07 Cerebral Amyloid Angiopathy Among survivors of intracerebral hemorrhage, a single pill with three low-dose antihypertensive agents added to standard care was associated with a lower incidence of stroke and major cardiovascular events than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2515043?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2515043 The Trident Research Group, Craig S. Anderson, Clara K. Chow, H. Asita de Silva, Bimsara Senanayake, Kolawole Wahab, Rustam Al-Shahi Salman, Catharina J.M. Klijn, Sheila Ouriques Martins, Natalie Espinosa, Lauren Kuhles, Laurent Billot, Hisatomi Arima, Cheryl Carcel, Xia Wang, Qiang Li, Sana Shan, Mathangi Shanthakumar, Huy Thang Nguyen, Dilum Palliyaguruge, Janaka Peiris, Udaya K. Ranawaka, Senaka Bandusena, Thambipillai Rajendiran, Darshana Wijegunasinghe, Harsha Gunasekera, Indunil Wijeweera, Athula Dissanayake, Ajantha Keshavaraj, Reginald O. Obiako, Rufus Akinyemi, Luiz Nasi, Rodrigo Bazan, Carla Heloisa Cabral Moro, Mariana Battaglini, Viviane Zétola, Wan Chung Law, Yuen Kang Chia, Dennis Cordato, Rohan Grimley, Anuradha Dahanayaka, Sonali Liyanagamage, Nilukshi Fernando, Nihara Abdul Rasheed, Nodar Kakabadze, Maia Beridze, Mythily Aravinthan, Vithoosan Sahathevan, Devasmitha Wijesundara, Pramith Ruwanpathirana, Wan Asyraf Wan Zaidi, Tinatin Kherkheulidze, Urs Fischer, Ana Cláudia de Souza, Tsong-Hai Lee, Christopher Chen, Octavio Pontes-Neto, Thompson Robinson, Jiguang Wang, Sharon L. Naismith, Michael Barnett, Carlos Delfino, Shoujiang You, Feifeng Liu, Candice Delcourt, Tom J. Moullaali, Tim Wilkinson, Neil Watson, Karla Santo, Qiao Han, Mariana Almudi Souza, Wilmar M.T. Jolink, Anderson Berni Cristofari, Zien Zhou, Floris H. Schreuder, Richard I. Lindley, Manuela Armenis, Mark Woodward, Ruth Freed, Lili Song, John Chalmers, Anthony Rodgers 2026-04-23 Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage Spinal epidural abscess is an infection in the epidural space commonly caused by Staphylococcus aureus. Symptoms include back pain, neck pain, fever, and neurologic symptoms. Prompt evaluation is important. https://www.nejm.org/doi/full/10.1056/NEJMra2412728?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2412728 Aaron J. Tande, Bradford L. Currier, Douglas R. Osmon 2026-04-23 Spinal Epidural Abscess Effective blood-pressure control is the cornerstone of management after intracerebral hemorrhage; it is both the primary determinant of risk and the most vital intervention for reducing the threat of a second vascular event.1 Yet, despite the availability of effective treatments, blood pressure remains poorly controlled in survivors of... https://www.nejm.org/doi/full/10.1056/NEJMe2600995?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2600995 Ayush Batra, Farzaneh Sorond 2026-04-23 Blood-Pressure Control after Intracerebral Hemorrhage — An Unbroken Glass Ceiling In this trial involving patients undergoing mechanical ventilation in the ICU, selective decontamination of the digestive tract did not result in a lower incidence of in-hospital death than standard care alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2506398?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2506398 The SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group 2026-04-16 Selective Decontamination of the Digestive Tract during Ventilation in the ICU In a placebo-controlled trial involving patients with noncardioembolic ischemic stroke or high-risk TIA, asundexian added to antiplatelet therapy led to a lower risk of ischemic stroke without increasing major bleeding. https://www.nejm.org/doi/full/10.1056/NEJMoa2513880?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2513880 Mukul Sharma, Qiang Dong, Teruyuki Hirano, Scott E. Kasner, Jeffrey L. Saver, Jaime Masjuan, Andrew M. Demchuk, Charlotte Cordonnier, Daniel Bereczki, Georgios Tsivgoulis, Roland Veltkamp, Ivan Staikov, Hee-Joon Bae, Bruce C.V. Campbell, Andrea Zini, I-Hui Lee, Martin Kovar, Robert Mikulik, Robin Lemmens, José M. Ferro, Thompson Robinson, Hanne Christensen, Serefnur Ozturk, Ronen R. Leker, Peter Turcani, Agnieszka Slowik, Pablo Amaya, Fan Kee Hoo, Gian Marco De Marchis, Michael Knoflach, P.N. Sylaja, Jukka Putaala, Jonathan M. Coutinho, H. Bart van der Worp, Evija Miglane, Vaidas Matijošaitis, Arne G. Lindgren, Gisele Sampaio Silva, Else Charlotte Sandset, Saule T. Turuspekova, Pierre Amarenco, Kevin N. Sheth, Eric E. Smith, John W. Eikelboom, Raed A. Joundi, Karleen Schulze, Lizhen Xu, Laura Heenan, Pablo Colorado, Lars Keller, Eva Muehlhofer, Christoph Neumann, Hardi Mundl, Ashkan Shoamanesh, the OCEANIC-STROKE Investigators* 2026-04-16 Asundexian for Secondary Stroke Prevention