The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology/Neurosurgery. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sat, 10 Oct 2026 23:22:02 GMT 2026 NEJM Group en-us 1440 In this study, the safety of ganglion cell–directed optogenetic therapy was evaluated in 10 participants with blindness due to advanced retinitis pigmentosa. https://www.nejm.org/doi/full/10.1056/NEJMoa2602215?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2602215 José-Alain Sahel, Stefan Futterknecht, Isabelle Audo, Joseph N. Martel, Shouyu Ling, Chloé Pagot, Angelo Arleo, Elise Boulanger-Scemama, Antonin Duret, Jean-Baptiste de Saint Aubert, Alexandre Delaux, Simona Degli Esposti, Cécilia Coen, Caroline de Montleau, Dana Aravich, William Smith, Cecile Hayem, Magali Taiel, Marlene Behrmann, Botond Roska 2026-10-08 Optogenetic Therapy for Restoring Aspects of Visual Function The author describes the science behind a study of intravitreal delivery of an AAV vector encoding a light-gated ion channel in 10 blind patients with advanced retinitis pigmentosa. https://www.nejm.org/doi/full/10.1056/NEJMe2610388?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2610388 Karl Deisseroth 2026-10-08 Science behind the Study: Optogenetics in Sight A 2-month-old boy was brought to the ED after a seizure. The scalp hair was sparse and coarse. Serum copper and ceruloplasmin levels were markedly low. MR angiography showed tortuosity of the intracranial and extracranial arteries. https://www.nejm.org/doi/full/10.1056/NEJMicm2607595?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2607595 Hsin-Yu Chen, Chi-Nien Chen 2026-10-08 Menkes Disease In older adults without cardiovascular disease, treatment with atorvastatin led to a lower risk of major cardiovascular events than placebo at a median of 5.9 years but did not result in longer disability-free survival. https://www.nejm.org/doi/full/10.1056/NEJMoa2607314?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2607314 Sophia Zoungas, Rory Wolfe, Chris Moran, Stephen J. Nicholls, Geoffrey C. Cloud, Christopher M. Reid, Andrew M. Τonkin, Lawrence Beilin, Anthony S. Wierzbicki, Trevor T.-J. Chong, Jonathan C. Broder, Andrea J. Curtis, Zachary Flanagan, Ingrid Hopper, Joanne Ryan, Simone Spark, John J. McNeil, Mark R. Nelson, the STAREE Investigators 2026-10-01 Atorvastatin, Cardiovascular Events, and Disability-free Survival in Older Adults When a robust long-time patient with chronic pain and heavy alcohol use declines precipitously after a complicated hospital course, her medical team must find a way to revive her old self. https://www.nejm.org/doi/full/10.1056/NEJMp2603393?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2603393 Michael A. Incze, Laura Stolebarger 2026-10-01 The Mayor For decades, one of the most important unresolved questions in preventive cardiovascular medicine has been whether statin therapy should be initiated for primary prevention in healthy older adults. Although age is among the strongest determinants of absolute risk, the benefits of statin therapy beyond 70 to 75 years of age... https://www.nejm.org/doi/full/10.1056/NEJMe2611127?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2611127 Martin Bødtker Mortensen 2026-10-01 Statins in Older Adults — Evidence at Last A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2607537?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2607537 Hiro Takefuji, Junpei Komagamine 2026-10-01 Serotonin Syndrome In four patients with bilateral vocal-fold paralysis, bilateral neuromuscular laryngeal pacing was found to restore vocal-fold abduction, increase inspiratory flow, and preserve voice and swallowing function. https://www.nejm.org/doi/full/10.1056/NEJMc2603650?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2603650 Maria E. Powell, Yike Li, Kate Von Wahlde, Li-Ching Huang, Sarah L. Rhode, Gaelyn Garrett, Kenji Kobayashi, Robert H. Ossoff, Roland D. Eavey, Eben Rosenthal, James L. Netterville, Alexander Gelbard, David L. Zealear 2026-10-01 Bilateral Pacing Neuromuscular Prosthesis for Laryngeal Paralysis In two placebo-controlled trials, oveporexton improved wakefulness, reduced daytime sleepiness, and lowered the cataplexy rate among patients with narcolepsy type 1. Increased urinary frequency and transient insomnia were common. https://www.nejm.org/doi/full/10.1056/NEJMoa2601598?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601598 Yves Dauvilliers, Emmanuel Mignot, Jakub Antczak, Isabelle Arnulf, Lucie Barateau, Erik Buntinx, Bruce Corser, Alex Iranzo, Ramin Khatami, Gert Jan Lammers, Katharina Lederer, Kristian Bernhard Nilsen, Fabio Pizza, Markus H. Schmidt, Sheila Sivam, Oliver Sum-Ping, Mitsutaka Taniguchi, Shuqin Zhan, Anson Abraham, Alice Cai, Yeting Du, Mark R. Etherton, Helene Faessel, Samuel Hsiao, Harisha Kadali, Elena Koundourakis, Melissa Naylor, Rachel Neuwirth, Tina Olsson, Raquel Rogers, Sarah Sheikh, Shinichiro Tanaka, Philipp von Rosenstiel, Christian von Hehn, Yaming Hang, Baiyun Yao, Rafael del Rio Villegas, Giuseppe Plazzi 2026-09-24 Oveporexton for Narcolepsy Type 1 — Results from Two Phase 3 Trials A 4-year-old boy presented with fatigue and frequent falls. After falling, he could not stand up using his legs and would instead push himself up with his hands. The aminotransferase levels were elevated. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603181?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603181 Alexy D. Arauz Boudreau, Hee Mang Yoon, Brenda L. Wong 2026-09-24 Case 27-2026: A 4-Year-Old Boy with Fatigue, Imbalance, and Frequent Falls A rice farmer presented to the ED after a 1-minute episode of arm and leg shaking on the right side. MRI showed linear enhancement associated with a cluster of enhancing nodules and surrounding edema in the left frontal lobe. https://www.nejm.org/doi/full/10.1056/NEJMicm2609443?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2609443 Mary-France G. Lebii, Bonifacio C. Pedregosa II 2026-09-24 Cerebral Schistosomiasis For more than 25 years, narcolepsy type 1 (formerly narcolepsy with cataplexy) has been known to be associated with a deficiency of orexin within cerebrospinal fluid (CSF) and reduced staining of orexin-containing hypothalamic neurons on autopsy.1 Subsequent work has led to the current understanding of narcolepsy type 1... https://www.nejm.org/doi/full/10.1056/NEJMe2607491?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2607491 Lynn Marie Trotti 2026-09-24 Targeted Treatment for Narcolepsy Type 1 Drs. Yanagisawa and Mignot received the 2026 Albert Lasker Award for Basic Medical Research for their pivotal work in the discovery of the orexin (hypocretin) system and its role in narcolepsy. https://www.nejm.org/doi/full/10.1056/NEJMcibr2608811?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcibr2608811 Sebastiaan Overeem, Birgitte R. Kornum 2026-09-24 The Legacy of Orexin (Hypocretin) Research in Narcolepsy and Beyond A 62-year-old woman with a history of stroke and metastatic breast cancer that was being treated with immunomodulator therapy presented with memory loss, confabulation, anhedonia, ataxia, and weight loss. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603180?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603180 Sejal B. Shah, Robert H. Unger, Emily M. Sorg 2026-09-17 Case 26-2026: A 62-Year-Old Woman with Memory Loss, Anhedonia, and Temporal Wasting A 54-year-old woman presented to the emergency department with progressive asthenia, falls, and dyspnea. Physical examination and muscle biopsy provided clues to the diagnosis. https://www.nejm.org/doi/full/10.1056/NEJMicm2516626?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2516626 Sofia S. Rodrigues, Ines Marques Ferreira 2026-09-17 Late-Onset Pompe Disease A 36-year-old man presented with a 1-week history of asymptomatic anisocoria. On examination, the right pupil was dilated and constricted minimally to light and the left pupil constricted briskly to light (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2606883?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2606883 Aaron Donnelly, Richard Farnan 2026-09-10 Adie Tonic Pupil Trichodysplasia spinulosa–associated polyomavirus was identified as a likely cause of neuroinvasive infection in a 16-year-old patient who had undergone renal transplantation. https://www.nejm.org/doi/full/10.1056/NEJMc2602730?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2602730 Aaron Bodansky, Natalie Pierson, Venice Servellita, Kaitlin Marquis, Robert Valdovinos, Nahid Hiermandi, Andrew W. Bollen, Ilay Caliskan, Kanish Mirchia, Charles Omura, Jessica Streithorst, Brian LaFranchi, Timothy J. Henrich, Chung-Yu Wang, Bryan Castillo-Rojas, William Bernal, Alexandra Bicki, Erica Winnicki, Marsha Lee, Kelsey Zorn, Sukhman Sidhu, Orit Glenn, Mary Karalius, Matt S. Zinter, Kendall Nash, Michael R. Wilson, Thomas M. Tarro, Joseph L. DeRisi, Charles Y. Chiu 2026-09-10 Neuroinvasive Trichodysplasia Spinulosa–Associated Polyomavirus Infection Among 16 patients with refractory neurologic autoimmune disorders, lentiviral CD19 CAR T-cell therapy was associated with manageable side effects, complete B-cell depletion, and preliminary clinical improvement across disease groups. https://www.nejm.org/doi/full/10.1056/NEJMc2603114?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2603114 Yu-Hang Cheng, Ke Shang, Chuan Qin, Ming-Hao Dong, Yun-Hui Chu, Ke Huang, Zhi-Cheng Mei, Jun Xiao, Zi-Hao Liang, Yu-Hang Li, Wei Wang, Dai-Shi Tian 2026-09-03 Lentiviral In Vivo CD19 CAR T-Cell Therapy in Neurologic Autoimmune Disorders A 74-year-old man with myasthenia gravis was evaluated for dyspnea, proximal muscle weakness, hypoxemia, and a painful tongue lesion. Medications included prednisone and mycophenolate mofetil. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2603179?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2603179 Pierre O. Ankomah, Cynthia L. Czawlytko, Joseph B. El Khoury, Stefen Andrianus, M. Lauren Donnelly-Morell 2026-08-20 Case 24-2026: A 74-Year-Old Man with Dyspnea, Proximal Muscle Weakness, and Hypoxemia A proposed reclassification of medical marijuana products as Schedule III drugs would address only two of the three key barriers to research on marijuana’s safety and effectiveness for various indications. https://www.nejm.org/doi/full/10.1056/NEJMp2606593?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2606593 Rebecca L. Haffajee, Robert A. Mikos, Ziva D. Cooper 2026-08-20 Marijuana Rescheduling — A Game Changer for Research?