The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sun, 20 Sep 2026 12:55:41 GMT 2026 NEJM Group en-us 1440 The turmoil of the past 20 months has inflicted lasting damage on American science and public health. But history and recent events suggest that the attacks will subside. https://www.nejm.org/doi/full/10.1056/NEJMp2605442?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605442 David Blumenthal, James A. Morone 2026-09-19 The End of the War on Biomedical Science? To address drivers of poor child health, society should move from responding to health crises one symptom and one child at a time to reimagining ecosystems in ways that facilitate healthy development. https://www.nejm.org/doi/full/10.1056/NEJMp2609124?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2609124 Christopher B. Forrest, Neal Halfon 2026-09-19 Declining Child Health in the United States — Addressing the Developmental Ecosystem How can anyone in the U.S. medical community help children facing down the demons unleashed on them by the human traffickers entrusted with delivering them to better lives? https://www.nejm.org/doi/full/10.1056/NEJMp2601340?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601340 Brandon Oddo 2026-09-19 Gaps and Borders Among children with high-risk B-cell acute lymphoblastic leukemia, two cycles of blinatumomab led to a higher 4-year event-free survival than two cycles of chemotherapy (83.0% vs. 70.3%), with a lower risk of serious infection. https://www.nejm.org/doi/full/10.1056/NEJMoa2604166?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2604166 Martin Schrappe, Franco Locatelli, Maria Grazia Valsecchi, Gerhard Zugmaier, Michaela Vossen-Gajcy, Jan Starý, Andishe Attarbaschi, Anja Möricke, Jean-Pierre Bourquin, Draga Barbaric, Sarah Elitzur, Daniela Silvestri, Alexandra Kolenova, Luciano Dalla-Pozza, Nicole Bodmer, Martin Stanulla, Julia Alten, Faraz Zaman, Anke Bergmann, Giovanni Cazzaniga, Monika Brüggemann, Barbara Buldini, Rolf Köhler, Grazia Fazio, Claudia Rössig, Lucie Sramkova, Rosanna Parasole, Patrick Hundsdörfer, Maria Caterina Putti, Arndt Borkhardt, Franca Fagioli, Laura Rachele Bettini, Fiona Poyer, Arend von Stackelberg, Luciana Vinti, Valentino Conter, Martin Zimmermann, Carmelo Rizzari, Gunnar Cario, Andrea Biondi, the AIEOP-BFM ALL 2017 Consortium* 2026-09-17 Blinatumomab for Replacing Chemotherapy in Pediatric Acute Lymphoblastic Leukemia Among infants with a family history of allergy, a maternal diet high in eggs and peanuts during pregnancy and lactation did not result in a lower risk of egg or peanut allergy at 1 year than a standard diet. https://www.nejm.org/doi/full/10.1056/NEJMoa2605659?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2605659 Debra J. Palmer, Dianne E. Campbell, Ralph Nanan, Peter S. Hsu, Anita M. Jorgensen, Michael O’Sullivan, Merryn J. Netting, Vicki McWilliam, Susan L. Prescott, Michael S. Gold, Kirsten P. Perrett, Maria Makrides, Thomas R. Sullivan 2026-09-17 Trial of a Maternal Diet Rich in Eggs and Peanuts to Reduce Infant Allergy Research involving the treatment of pediatric acute lymphoblastic leukemia (ALL) established the paradigm for improving survival in cancer. In iterative clinical trials conducted by cooperative groups, long-term survival has improved from less than 10% to 90% owing to the use of improved multidrug regimens and treatment tailored to clinical and... https://www.nejm.org/doi/full/10.1056/NEJMe2610500?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2610500 Regina M. Myers, Stephen P. Hunger 2026-09-17 Blinatumomab — A New Standard of Care in Acute Lymphoblastic Leukemia Food-allergy prevention has undergone a major conceptual shift over the past decade. After years in which avoidance of allergenic foods during infancy, and sometimes during pregnancy and lactation, was considered to be a biologically plausible strategy to prevent food allergy, randomized trials of early infant feeding changed practice by showing... https://www.nejm.org/doi/full/10.1056/NEJMe2610158?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2610158 Maria C. Jenmalm 2026-09-17 Maternal Allergen Consumption and Infant Food Allergy — Reassurance, Not Prescription Policymakers have so far failed to hold perpetrators in Jeffrey Epstein’s trafficking network accountable, but the medical and public health community should confront the resulting health crisis. https://www.nejm.org/doi/full/10.1056/NEJMp2605483?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2605483 Nicholas Peoples, Preeti Panda, Hanni Stoklosa 2026-09-17 The Epstein Files Transparency Act and the Health of Trafficked Children Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease. https://www.nejm.org/doi/full/10.1056/NEJMc2605960?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2605960 Christian Irsara, Habib Benainouna, Jing Jing Wang, Andrea Griesmacher, Christoph Winkler, Lorin Loacker, Markus Anliker, Xiaoyan Wang, Alex Moser, Thomas Müller, Werner Streif, Andreas Greinacher, Thomas Thiele, Wibke Bayer, Linda Schönborn 2026-09-17 Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis The authors report the results of interim analyses of two phase 3 studies of exa-cel, a gene-edited cellular therapy, in children with transfusion-dependent β-thalassemia or sickle cell disease. https://www.nejm.org/doi/full/10.1056/NEJMoa2603387?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2603387 Haydar Frangoul, Josu de la Fuente, Yogi Chopra, Roland Meisel, Persis J. Amrolia, Mattia Algeri, Akshay Sharma, Maria Domenica Cappellini, Selim Corbacioglu, Antonis Kattamis, Stephan Lobitz, Mariane de Montalembert, Damiano Rondelli, Sujit Sheth, Martin H. Steinberg, Mark C. Walters, Kevin Boerner, Tina Liu, Sakellarios Zairis, William Hobbs, Stephan A. Grupp, Franco Locatelli, the CLIMB THAL-141 and CLIMB SCD-151 Study Groups* 2026-09-10 Exa-cel in Children with Transfusion-Dependent β-Thalassemia or Sickle Cell Disease Sickle cell disease and β-thalassemia are highly prevalent inherited conditions associated with serious complications and a shortened life span. Transfusions in patients with severe β-thalassemia and hydroxyurea therapy in those with sickle cell disease can improve outcomes for many of these patients, yet early diagnosis, consistent access to safe blood... https://www.nejm.org/doi/full/10.1056/NEJMe2607923?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2607923 Alexis A. Thompson 2026-09-10 Advancing Gene Editing for Children with Hemoglobinopathies During Operation Metro Surge in Minneapolis, volunteer health care professionals quickly improvised a new system, often without institutional authorization, to continue to care for terrified patients. https://www.nejm.org/doi/full/10.1056/NEJMp2607981?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2607981 Munira Maalimisaq, Jennifer Needle-Suarez 2026-09-10 When Fear Became the Barrier to Care — Lessons of a Clinical Rapid Response during Operation Metro Surge A 3-year-old boy with chemotherapy-resistant metastatic hepatoblastoma had complete regression lasting at least 12 months after two infusions of glypican-3–specific CAR T cells coexpressing interleukin-15 and interleukin-21. https://www.nejm.org/doi/full/10.1056/NEJMc2605958?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2605958 David Steffin, Amy N. Courtney, Michelle Choe, Nisha Ghatwai, Magdalena A. Esparza Cerda, Ramy Sweidan, Rajdekar Dhanashree, Huimin Zhang, Natasha Lapteva, Zhuyong Mei, Bambi J. Grilley, Leonid S. Metelitsa, Helen E. Heslop, Malcolm K. Brenner, Andras Heczey 2026-09-10 Complete Regression of Hepatoblastoma after Interleukin-15– and Interleukin-21–Coexpressing CAR T-Cell Therapy Trichodysplasia spinulosa–associated polyomavirus was identified as a likely cause of neuroinvasive infection in a 16-year-old patient who had undergone renal transplantation. https://www.nejm.org/doi/full/10.1056/NEJMc2602730?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2602730 Aaron Bodansky, Natalie Pierson, Venice Servellita, Kaitlin Marquis, Robert Valdovinos, Nahid Hiermandi, Andrew W. Bollen, Ilay Caliskan, Kanish Mirchia, Charles Omura, Jessica Streithorst, Brian LaFranchi, Timothy J. Henrich, Chung-Yu Wang, Bryan Castillo-Rojas, William Bernal, Alexandra Bicki, Erica Winnicki, Marsha Lee, Kelsey Zorn, Sukhman Sidhu, Orit Glenn, Mary Karalius, Matt S. Zinter, Kendall Nash, Michael R. Wilson, Thomas M. Tarro, Joseph L. DeRisi, Charles Y. Chiu 2026-09-10 Neuroinvasive Trichodysplasia Spinulosa–Associated Polyomavirus Infection In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-09-03 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock In this phase 3, randomized trial involving children with achondroplasia (3 to 17 years of age), once-daily oral infigratinib for 1 year significantly increased the annualized height velocity as compared with placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2604565?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2604565 Ravi Savarirayan, Julie Hoover-Fong, Melita Irving, Paul Arundel, Josep Maria de Bergua, Philippe M. Campeau, Toby Candler, Benjamin T. Cocanougher, Valerie Cormier-Daire, Thomas Edouard, Svein O. Fredwall, Paul Harmatz, Daniel Hoernschemeyer, Henrik U. Irgens, Saumya Jamuar, Peter Kannu, Janet M. Legare, Antonio Leiva-Gea, Helen McDevitt, Roberta Onesimo, John Phillips III, Mariana del Pino, Marie-Eve Robinson, Massimiliano Rossi, Mars Skae, Leanne M. Ward, Klane K. White, Jane Schmidt, Ted Lystig, Ariana Salvatici, Yun Bai, Peter W. Butler, David van Veenhuyzen, Daniela Rogoff 2026-09-03 Phase 3 Trial of Oral Infigratinib in Children with Achondroplasia Achondroplasia, the most common skeletal dysplasia, is characterized by impaired longitudinal growth resulting in disproportionate short stature as well as craniofacial abnormalities, spinal stenosis, and increased mortality during infancy from cervicomedullary compression. This condition is caused by mutations in the gene encoding fibroblast growth factor receptor 3 (FGFR3) ,... https://www.nejm.org/doi/full/10.1056/NEJMe2609749?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609749 Isidro B. Salusky, Harald Jüppner 2026-09-03 Infigratinib in Achondroplasia — A Potentially Giant Step Forward Improving the clinical treatment of patients with sepsis remains a major focus of critical care physicians worldwide.1,2 To date, few studies in either the pediatric or adult literature have established universal management principles that reliably improve outcomes, which attests to the heterogeneity of this syndrome. Fluid resuscitation is... https://www.nejm.org/doi/full/10.1056/NEJMe2609856?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609856 Michael F. O’Connor, Juliane Bubeck-Wardenburg 2026-09-03 Fluid Resuscitation in Patients with Sepsis — For Whom the Balance Tolls Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria. https://www.nejm.org/doi/full/10.1056/NEJMoa2516505?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516505 Kurt R. Denninghoff, T. Charles Casper, Joseph J. Zorc, Richard M. Ruddy, Sarah Satola, Wendi-Jo Wendt, Claudia R. Morris, Melissa M. Tavarez, Matthew J. Lipshaw, Maria Y. Kwok, Jo-Ann O. Nesiama, Kyle A. Nelson, Michael Webb, Fernando D. Martinez, the PECARN AZ-SWED Trial Study Group* 2026-08-20 Azithromycin for Preschoolers with Wheezing in the Emergency Department Acute wheezing attacks are common in preschool-age children. These attacks lead to impaired quality of life1 and are associated with trajectories of poor lung function that may be lifelong, especially in children who are exposed to tobacco smoke and have allergic sensitization.2 Despite increased focus on... https://www.nejm.org/doi/full/10.1056/NEJMe2606675?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2606675 Andrew Bush, Sejal Saglani 2026-08-20 No to Azithromycin for Preschoolers with Acute Wheezing in the Emergency Department