The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pediatrics. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Wed, 29 Apr 2026 01:08:02 GMT 2026 NEJM Group en-us 1440 There has been substantial interest in the development of GLP-1 drugs and optimism about their public health effects. But some worrisome signals related to disordered eating have emerged. https://www.nejm.org/doi/full/10.1056/NEJMp2600300?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2600300 Amanda Banks 2026-04-25 GLP-1 Receptor Agonists and Eating Disorders — Cause for Concern In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-04-24 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained. https://www.nejm.org/doi/full/10.1056/NEJMp2518278?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2518278 Ian T.T. Liu, Florence Bourgeois 2026-04-23 Closing the Evidence Gap for Drugs in Children — Measures to Strengthen the Pediatric Research Equity Act In a randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month. https://www.nejm.org/doi/full/10.1056/NEJMoa2511478?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2511478 Siyuan Lin, Yuanchen He, Lan He, Yiling Liu, Fangjie Wang, Zhenyu Xiong, Yixiang Lin, Lan Ye, Chen Chu, Feng Wang, Lu Zhao, Yinyin Cao, Yuanzheng Zheng, Qin Huang, Jie Wang, Xuecun Liang, Quming Zhao, Shuna Sun, Yalan Dou, Wennan He, Xiaobi Huang, Jingwei Sun, Xianmei Huang, Yan Li, Yanling Liao, Haitao Lv, Silin Pan, Hua Zhu, Xinjiang An, Xuehua He, Cuifen Zhao, Xiaoyan Liu, Yaofei Hu, Jinhua Piao, Lijun Qin, Xiangyu Dong, Qian Peng, Ce Wang, Shubin Lin, Ping Huang, Rongzhou Wu, Hua Peng, Zipu Li, Duolao Wang, Xiaohui Liu, Weili Yan, Fang Liu, Guoying Huang, the Chinese Kawasaki Disease Collaboration Network* 2026-04-16 Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease In the final NOS episode of the season, host Lisa Rosenbaum and her guests elucidate the quiet beauty of good primary care and consider how to induce the U.S. health care system to prize it more highly. https://www.nejm.org/doi/full/10.1056/NEJMp2514244?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2514244 2026-04-16 Not Otherwise Specified — Season 3: The Forever Crisis of Primary Care: When No One’s Watching — NOS Episode 3.12 The Trump administration’s wide-ranging actions to dismantle U.S. environmental regulations will cause long-lasting health harms, disproportionately affecting low-income and other vulnerable groups. https://www.nejm.org/doi/full/10.1056/NEJMp2514370?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2514370 Adam W. Gaffney, David Himmelstein, Steffie Woolhandler, Sancia Sehdev, Philip J. Landrigan 2026-04-16 The Dismantling of Environmental Protections — A Grave Threat to America’s Health A 16-year-old girl presented with 1 month of ankle pain and 11 days of fever. Radiographs showed an ill-defined, radiolucent distal tibial lesion; on MRI, the lesion was hypointense and surrounded by a hyperintense sclerotic rim. https://www.nejm.org/doi/full/10.1056/NEJMicm2514540?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2514540 Haijian Li, Pei Han 2026-04-16 Intraosseous Abscess from Subacute Osteomyelitis Kawasaki disease is the most common cause of acquired heart disease in children in the developed world.1 Although Kawasaki disease manifests with acute, transient systemic signs, its long-term morbidity derives from necrotizing vasculitis that predominantly affects the coronary arteries.2,3 The primary goal of therapy during the... https://www.nejm.org/doi/full/10.1056/NEJMe2518759?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518759 Jane C. Burns, Jane W. Newburger 2026-04-16 Glucocorticoids in Kawasaki Disease — Refining Indications and the Science This review summarizes the epidemiology, diagnosis, and management of celiac disease and highlights serologic testing, biopsy confirmation, associated autoimmune conditions, and a gluten-free diet as treatment. https://www.nejm.org/doi/full/10.1056/NEJMcp2415548?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2415548 Joseph A. Murray, Steffen Husby 2026-04-09 Celiac Disease The types of immigration-enforcement actions being taken in the United States can activate children’s stress-response systems, disrupting neurodevelopment, immune function, and emotional regulation. https://www.nejm.org/doi/full/10.1056/NEJMp2601176?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2601176 Nikhil A. Patel, Amy Hunter, Royce B. Murray 2026-04-09 Effects of Pervasive Immigration Enforcement on Children’s Health A study in a mouse model of MYCN-amplified neuroblastoma implicates polyamine levels in affecting the makeup of the proteome and biologic characteristics of the tumor. https://www.nejm.org/doi/full/10.1056/NEJMcibr2516825?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcibr2516825 Michelle Haber, Murray D. Norris 2026-04-09 Altering the Diet to Rewire Cancer A collaboration between a college and a public school system centers young people’s health outcomes and considers family perceptions of neighborhood conditions as drivers of health-focused community development. https://www.nejm.org/doi/full/10.1056/NEJMp2516497?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516497 Elizabeth I. Ackley 2026-04-09 Efforts toward Equity: Leveraging School Systems as Data Partners to Advance Health Equity Findings from an analysis of deidentified electronic health record data from a national database indicate that the prevalence of youth-onset type 2 diabetes has increased substantially during the past decade. https://www.nejm.org/doi/full/10.1056/NEJMc2507615?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2507615 Michael Fang, Yunwen Xu, Elizabeth Selvin, Jung-Im Shin 2026-04-09 Trends in Youth-Onset Type 2 Diabetes, 2013–2024 In this study, a Cas12a–guide RNA complex was used to target the promoters of HBG1 and HBG2 in autologous stem cells to treat sickle cell disease. https://www.nejm.org/doi/full/10.1056/NEJMoa2415550?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2415550 Rabi Hanna, Haydar Frangoul, Luis Pineiro, Christopher McKinney, Markus Mapara, Jignesh Dalal, Hemalatha G. Rangarajan, Harold Atkins, Akshay Sharma, Kai-Hsin Chang, Michael C. Jaskolka, Keunpyo Kim, Qifeng Yu, Baisong Mei, Olubunmi Afonja, Mark C. Walters, the RUBY Investigators* 2026-04-02 CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat Sickle Cell Disease In this study, a Cas12a–guide RNA complex was used to target the promoters of HBG1 and HBG2 in autologous stem cells to treat transfusion-dependent β-thalassemia. https://www.nejm.org/doi/full/10.1056/NEJMoa2501277?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2501277 Haydar Frangoul, Rabi Hanna, Mark C. Walters, Roy L. Kao, Clinton Carroll, Meghann McManus, Kai-Hsin Chang, Michael C. Jaskolka, Keunpyo Kim, Qifeng Yu, Nnenna Badamosi, Baisong Mei, Olubunmi Afonja, Alexis Thompson, the EdiThal Investigators* 2026-04-02 CRISPR-Cas12a Gene Editing of HBG1 and HBG2 Promoters to Treat β-Thalassemia Transfusion-dependent β-thalassemia and sickle cell disease, both characterized by defective hemoglobin synthesis, are the most common monogenic diseases worldwide. Each year, approximately 60,000 infants are born with transfusion-dependent β-thalassemia, and 500,000 infants receive a diagnosis of sickle cell disease.1,2 Historically, patients with these disorders have rarely survived beyond... https://www.nejm.org/doi/full/10.1056/NEJMe2602194?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602194 Franco Locatelli 2026-04-02 More Options for Gene Editing in Hemoglobinopathies Chiles v. Salazar, a challenge to Colorado’s ban on conversion therapy, could seriously affect LGBTQ+ health, mental health professionals, and the legal relevance of standards of care. https://www.nejm.org/doi/full/10.1056/NEJMp2516723?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516723 Michael R. Ulrich 2026-04-02 Therapy’s Conversion — Chiles v. Salazar’s Threat to Mental Health Treatment and Standards of Care In a 12-year-old boy with severe idiopathic acute necrotizing pancreatitis, CT showed a right portal vein thrombus and a wedge-shaped area of hyperperfusion corresponding to the liver region supplied by the thrombosed vein. https://www.nejm.org/doi/full/10.1056/NEJMicm2516362?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2516362 Tushar Kumar, Sakura M. Noda 2026-04-02 Hepatic Arterial Buffer Response Alternative complement pathway overactivation contributes to IgA nephropathy. In a placebo-controlled trial, iptacopan, a complement factor B inhibitor, significantly slowed kidney-function decline in patients with IgA nephropathy. https://www.nejm.org/doi/full/10.1056/NEJMoa2600743?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600743 Jonathan Barratt, Necmi Eren, Naoki Kashihara, Bart Maes, Dana V. Rizk, Brad Rovin, Hernán Trimarchi, Hong Zhang, Weiming Wang, Ismail Kocyigit, Chuanming Hao, Vladimir Tesař, Kenan Turgutalp, Li Yang, Guangqun Xing, Valter Duro Garcia, Seung Hyeok Han, Wanhong Lu, Antonio Pisani, Julia Weinmann-Menke, Frank Eitner, Nicolas Guerard, Dmytro Butylin, Luca Monaco, Emil Scosyrev, Annabel Magirr, Ronny Renfurm, Thomas Hach, Vlado Perkovic, the APPLAUSE-IgAN Study Group* 2026-03-29 Iptacopan in IgA Nephropathy — Final 24-Month Data In this trial, among adolescents with obstructive hypertrophic cardiomyopathy, the cardiac myosin inhibitor mavacamten led to a significantly greater reduction in left ventricular outflow tract obstruction than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2601103?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601103 Joseph W. Rossano, Charles Canter, Cordula M. Wolf, Andrew Papez, Marta Gambra, Randall M. Bryant, Juan Alejos, Michael McCulloch, Georgia Sarquella Brugada, Matthew J. Bock, Aamir Jeewa, F. Bennett Pearce, Milind Y. Desai, Nicholas Favatella, Atefeh Javidialsaadi, Van Phung, Thomas Rano, Lin Zhu, Joshua L. Dyme, Seema Mital, the SCOUT-HCM Investigators* 2026-03-29 Mavacamten in Adolescents with Obstructive Hypertrophic Cardiomyopathy