The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary/Critical Care. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sun, 12 Apr 2026 12:41:12 GMT 2026 NEJM Group en-us 1440 A 68-year-old man who had undergone intubation 25 days earlier had difficulty swallowing after extubation. A swallowing study showed fluid penetrating into the trachea without triggering a cough reflex (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2516115?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2516115 Shuo-Ting Jian, Hsiu-Nien Shen 2026-04-09 Silent Aspiration Chronologic age plays an outsized role in various aspects of medicine. Yet people of the same age can differ dramatically when it comes to aging-related risk factors. https://www.nejm.org/doi/full/10.1056/NEJMp2516973?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2516973 Martin G. Lee 2026-04-02 The Age Illusion — Limitations of Chronologic Age in Medicine In a simulation involving 15 healthy trainees, slowing respiration to 10 seconds per breath produced pulsus measurements exceeding 20 mm Hg, enabling improved teaching simulation and understanding of underlying physiology. https://www.nejm.org/doi/full/10.1056/NEJMc2518685?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2518685 Rona Yu, Glen Cook, J. Edwin Atwood 2026-04-02 Simulating and Teaching the Physiology of Pulsus Paradoxus In patients with pulmonary embolism, ultrasound-facilitated, catheter-directed fibrinolysis led to a lower risk of a composite of major adverse outcomes than anticoagulation alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2516567?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516567 Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, Andrew S.P. Sharp, Fionnuala Ní Áinle, Michael R. Jaff, Stefano Barco, Samuel Z. Goldhaber, Nils Kucher, Irene M. Lang, Irene Schmidtmann, Keith M. Sterling, Aleksander Araszkiewicz, Vishal Arora, Rafael Cires-Drouet, John Coghlan, Lukas Hobohm, Wulf D. Ito, Kurt Jacobson, Christoph Kaiser, Grzegorz Kopec, Kristin Marx, Samuel McElwee, Nicolas Meneveau, Peter Monteleone, Jose M. Montero-Cabezas, Christoph B. Olivier, John Park, Marek Roik, Rahul Sakhuja, Andi Tego, Markus Theurl, Gautam Visveswaran, Jan Albert Vos, Michael N. Young, Federico M. Asch, Stavros V. Konstantinides, the HI-PEITHO Investigators* 2026-03-28 Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism Pulmonary embolism is the third leading cardiovascular cause of complications and death after myocardial infarction and stroke, with a rising incidence globally.1 The approach to management of acute pulmonary embolism as a condition to be treated nonsurgically with systemic heparin anticoagulation was established more than 60 years ago. https://www.nejm.org/doi/full/10.1056/NEJMe2603115?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2603115 Alex C. Spyropoulos, Suresh Vedantham 2026-03-28 Advanced Therapy for Intermediate-Risk Pulmonary Embolism A woman with a history of necrotizing pancreatitis presented with abdominal pain and fevers. CT showed a fluid collection with gas and septations in the pancreatic region. A retroperitoneal necrosectomy was performed (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2515752?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2515752 Zhuo-Long Tu, Jin-Fu Tu 2026-03-26 Walled-Off Pancreatic Necrosis The Trump administration’s wide-ranging actions to dismantle U.S. environmental regulations will cause long-lasting health harms, disproportionately affecting low-income and other vulnerable groups. https://www.nejm.org/doi/full/10.1056/NEJMp2514370?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2514370 Adam W. Gaffney, David Himmelstein, Steffie Woolhandler, Sancia Sehdev, Philip J. Landrigan 2026-03-25 The Dismantling of Environmental Protections — A Grave Threat to America’s Health In a multicenter trial involving patients with acute hypoxemic respiratory failure, 28-day mortality with high-flow oxygen was not significantly different from that with standard oxygen. https://www.nejm.org/doi/full/10.1056/NEJMoa2516087?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516087 Jean-Pierre Frat, Jean-Pierre Quenot, Christophe Guitton, Rémi Coudroy, Arnaud Gacouin, Julio Badie, Alexandre Demoule, Damien Contou, Guillaume Carteaux, Stephan Ehrmann, Fabien Jarousseau, Nicholas Sedillot, Jean-Philippe Rigaud, Jean Reignier, François Beloncle, Anne-Florence Dureau, Alexis Ferré, Cédric Daubin, Anna Bourreau, Agathe Delbove, Gaël Pradel, Abdelhamid Fatah, Gwenhael Colin, Guillaume Deniel, Olivier Lamouret, Béatrice La Combe, Gwénaël Prat, Louis-Marie Galerneau, Gaël Bourdin, Gautier Julien, Anaïs Curtiaud, Mélanie Saint-Léger, Emanuele Turbil, Faustine Reynaud, Louis Chamblet, Stéphanie Ragot, Arnaud W. Thille, the SOHO Trial Group and the REVA Network* 2026-03-17 High-Flow or Standard Oxygen in Acute Hypoxemic Respiratory Failure Among patients with traumatic hemorrhage, prehospital whole-blood transfusion was not superior to standard transfusion with red-cell and plasma components in reducing the risk of death or massive transfusion. https://www.nejm.org/doi/full/10.1056/NEJMoa2516043?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516043 Jason E. Smith, Rebecca Cardigan, Emily Sanderson, Laura Silsby, Claire Rourke, Ed B.G. Barnard, Peter Basham, Grazia Antonacci, Richard Charlewood, Nikki Dallas, Jane Davies, Elizabeth Goodwin, Annie Hawton, Cara Hudson, Joanne Lucas, Katie Keen, Richard M. Lyon, Brodie Nolan, Gavin D. Perkins, Viona Rundell, Laura Smith, Simon J. Stanworth, Anne Weaver, Tom Woolley, Laura Green, the SWiFT Trial Group* 2026-03-17 Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial Acute hypoxemic respiratory failure remains one of the most common conditions encountered in the intensive care unit (ICU).1 During the past decade, high-flow nasal oxygen has moved from physiological curiosity to frontline therapy.2 Early enthusiasm followed the publication of the results of the 2015 FLORALI trial, https://www.nejm.org/doi/full/10.1056/NEJMe2602037?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2602037 Ary Serpa Neto 2026-03-17 Rethinking High-Flow Oxygen in Acute Hypoxemic Respiratory Failure In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. https://www.nejm.org/doi/full/10.1056/NEJMoa2510703?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2510703 Lana A. Castellucci, Vivien M. Chen, Michael J. Kovacs, Alejandro Lazo-Langner, Peter Greenstreet, Susan Kahn, Benoit Côté, Sam Schulman, Kerstin de Wit, James Douketis, Deepa Suryanarayan, Tony Wan, Erik Yeo, Genevieve Le Templier, Huyen A. Tran, Abbey Willcox, Helen J. Crowther, Ritam Prasad, Sudeep Shivakumar, Etimbuk Umana, Fionnuala Ni Ainle, Tobias Tritschler, Stefano Barco, Jean-Philippe Galanaud, Marc Blondon, Lisa Baumann Kreuziger, Susan Solymoss, Clive Kearon, Erin Thomas, Tim Ramsay, Gregoire Le Gal, Marc Rodger, the COBRRA Trial Investigators† 2026-03-12 Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism The landscape of treatment options for venous thromboembolism was transformed by the arrival of direct oral anticoagulants. Large-scale trials showed that the direct oral anticoagulants apixaban and rivaroxaban were noninferior to vitamin K antagonists in terms of efficacy and had a better safety profile. However, for over a decade, a... https://www.nejm.org/doi/full/10.1056/NEJMe2600525?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2600525 Lisa K. Moores 2026-03-12 The COBRRA Trial — Ending the Venous Thromboembolism Safety Toss-up In a phase 3 trial involving patients with idiopathic pulmonary fibrosis, inhaled treprostinil was associated with a smaller decline in forced vital capacity and a lower risk of clinical worsening than placebo over 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2512911?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2512911 Steven D. Nathan, Peter Smith, Chunqin Deng, Maria De Salvo, Wim Wuyts, Juana Pavie-Gallegos, Jin Woo Song, Mordechai R. Kramer, Christopher S. King, John A. Mackintosh, Daniel Chambers, Georgina Viviana Miranda, Natalie Breytenbach, Leigh Peterson, Heidi Bell, Kevin R. Flaherty, Juergen Behr, Vincent Cottin, the TETON-2 Trial Investigators* 2026-03-11 Inhaled Treprostinil for Idiopathic Pulmonary Fibrosis A woman with asthma and obstructive sleep apnea presented with a 1-month history of worsening dyspnea and dry cough. CT of the chest showed anterior bowing of the posterior wall of the intrathoracic trachea during expiration. https://www.nejm.org/doi/full/10.1056/NEJMicm2503296?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2503296 Hadi Jaradeh, Alejandro P. Comellas 2026-03-05 Expiratory Central Airway Collapse A CD19-targeted therapy induced remission in a woman with refractory immune thrombocytopenia and antiphospholipid syndrome by stabilizing platelet counts, eliminating pathogenic antibodies, and enabling safer long-term anticoagulation. https://www.nejm.org/doi/full/10.1056/NEJMc2516228?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2516228 Adrian Gottschlich, Veit Bücklein, Karim El-Marouk, Rainer Kaiser, Michael Schmid, Thomas A. Janert, Michael Winkelmann, Frank Ziemann, Gerulf Hänel, Stefan Handtke, Thomas Thiele, Christian Wichmann, Sebastian Kobold, Gerhard Zugmaier, Christian Rausch, Hendrik Schulze-Koops, Lars H. Lindner, Karsten Spiekermann, Michael von Bergwelt-Baildon, Marion Subklewe 2026-03-05 Blinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome When a physician’s own incidental finding sends her down a long and winding path to find answers, she finds herself overcome with worry — but also, eventually, a new appreciation for life. https://www.nejm.org/doi/full/10.1056/NEJMp2509681?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2509681 Sarah Lee 2026-02-26 An Incidental Finding Unraveled Medicare will achieve greater savings on the 15 drugs in its second round of price negotiations than it did in the first round. Despite new challenges, the effort should continue to pay growing dividends. https://www.nejm.org/doi/full/10.1056/NEJMp2517584?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2517584 Benjamin N. Rome, Aaron S. Kesselheim 2026-02-26 The Growing Success of Medicare Drug-Price Negotiation A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513546?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513546 Pavan K. Bendapudi, Maximiliano Klug, Sharl S. Azar, Mandakolathur R. Murali, Ayman Al Jurdi 2026-02-19 Case 6-2026: A 91-Year-Old Man with Shortness of Breath, Weight Loss, and Eosinophilia In Latin America, though overall smoking rates have declined, nondaily and low-intensity smoking are increasingly common, and tobacco-cessation resources remain underdeveloped in many countries. https://www.nejm.org/doi/full/10.1056/NEJMp2500630?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMp2500630 Laura Llambi, Paola Morello 2026-02-19 Reducing Tobacco Use Worldwide: Tobacco Cessation among Nondaily and Low-Intensity Smokers — Challenges and Opportunities in Latin America A 49-year-old man with acute myeloid leukemia was evaluated for prolonged neutropenic fever. On examination, there were crackles at the lung bases. CT of the chest revealed a reversed halo sign. https://www.nejm.org/doi/full/10.1056/NEJMicm2511883?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2511883 Jonas Lötscher, Justus Baarts 2026-02-12 Pulmonary Mucormycosis