The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Pulmonary/Critical Care. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Sat, 10 Oct 2026 23:18:59 GMT 2026 NEJM Group en-us 1440 Among adults with septic shock, the use of restricted fluids and early vasopressors did not result in more days alive and out of the hospital through day 90 than the use of liberal fluids and later vasopressors. https://www.nejm.org/doi/full/10.1056/NEJMoa2516225?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516225 The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network 2026-10-08 Vasopressors or Fluids in Early Septic Shock Septic shock — the dysregulated response to infection that leads to end-organ hypoperfusion — remains a worldwide threat to patient’s lives and ability to thrive.1 There is consensus that excellent care for patients with septic shock involves early source control to limit the dysregulated “friendly fire” response in... https://www.nejm.org/doi/full/10.1056/NEJMe2609170?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609170 Theodore J. Iwashyna 2026-10-08 More Than One Way to Save a Life in Septic Shock Andes virus, the sole orthohantavirus with documented human-to-human transmission, causes hantavirus pulmonary syndrome (case fatality rate, 25 to 40%). Aggressive supportive care and strict infection-control measures are needed. https://www.nejm.org/doi/full/10.1056/NEJMra2606651?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2606651 Gavin H. Harris, Anabel Sinchi, James Lawler, Maria Frank 2026-10-01 Andes Virus — A Clinical Review A 23-year-old man was brought to the ED after intentional ingestion of 2000 mg of sertraline. Six hours after ingestion, spontaneous and sustained, inducible clonus and patellar hyperreflexia were noted in his legs (shown in a video). https://www.nejm.org/doi/full/10.1056/NEJMicm2607537?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2607537 Hiro Takefuji, Junpei Komagamine 2026-10-01 Serotonin Syndrome In four patients with bilateral vocal-fold paralysis, bilateral neuromuscular laryngeal pacing was found to restore vocal-fold abduction, increase inspiratory flow, and preserve voice and swallowing function. https://www.nejm.org/doi/full/10.1056/NEJMc2603650?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2603650 Maria E. Powell, Yike Li, Kate Von Wahlde, Li-Ching Huang, Sarah L. Rhode, Gaelyn Garrett, Kenji Kobayashi, Robert H. Ossoff, Roland D. Eavey, Eben Rosenthal, James L. Netterville, Alexander Gelbard, David L. Zealear 2026-10-01 Bilateral Pacing Neuromuscular Prosthesis for Laryngeal Paralysis In this trial involving participants with obesity, retatrutide, a triple hormone receptor agonist, resulted in substantial weight reduction and a decrease in knee osteoarthritis pain and obstructive sleep apnea events. https://www.nejm.org/doi/full/10.1056/NEJMoa2604169?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2604169 Ania M. Jastreboff, Lee M. Kaplan, Melanie J. Davies, John P.H. Wilding, Nadia N. Ahmad, Megan Murray, Yu Du, Nune Makarova, Kathryn Giblin, Nanette C. Schloot, Yan Wang, the TRIUMPH-1 Investigators* 2026-09-29 Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity Among critically ill adults with metabolic acidosis receiving vasopressors in the ICU, sodium bicarbonate did not lead to a lower risk of major adverse kidney events within 30 days than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2600526?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2600526 The SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group 2026-09-17 Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock Acute metabolic acidosis is common in hospitalized patients owing to conditions such as shock, kidney disease, and diabetic ketoacidosis. While the underlying cause is being treated, it may be tempting to use buffer solutions concurrently to try to raise extracellular pH, particularly in critically ill patients. Clinical approaches to this... https://www.nejm.org/doi/full/10.1056/NEJMe2610218?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2610218 Marlies Ostermann, Deborah J. Cook 2026-09-17 Sodium Bicarbonate in Critical Illness — A New Chapter for the Book Virus-induced immune thrombocytopenia and thrombosis after HAdV-B3 infection supports a shared platelet factor 4–targeted immune mechanism linking natural adenovirus infection and adenoviral vector–associated disease. https://www.nejm.org/doi/full/10.1056/NEJMc2605960?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMc2605960 Christian Irsara, Habib Benainouna, Jing Jing Wang, Andrea Griesmacher, Christoph Winkler, Lorin Loacker, Markus Anliker, Xiaoyan Wang, Alex Moser, Thomas Müller, Werner Streif, Andreas Greinacher, Thomas Thiele, Wibke Bayer, Linda Schönborn 2026-09-17 Human Adenovirus B3–Induced Immune Thrombocytopenia and Thrombosis A 46-year-old man with cirrhosis presented with a 1-week history of left flank pain. Physical examination was notable for a large ecchymosis on the left flank that was tender to palpation. https://www.nejm.org/doi/full/10.1056/NEJMicm2605791?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2605791 Kan-Ru Li, Chien Hao Lin 2026-09-10 Grey Turner’s Sign In two replicate phase 3 trials involving patients with COPD who were receiving inhaled maintenance therapy, add-on tozorakimab resulted in a lower rate of moderate or severe exacerbations than placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2606998?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2606998 Frank C. Sciurba, Henrik Watz, Arnaud Bourdin, Wim Janssens, Fernando J. Martinez, Jinping Zheng, Maarten van den Berge, Matteo Bonini, MeiLan K. Han, Dave Singh, Gerard J. Criner, Christopher E. Brightling, Alberto Papi, Surya P. Bhatt, Martin Jenkins, Marta Mikosz, Piotr Chołbiński, Monika Ziemiecka, Magnus Löfdahl, Deepa Arya, Madhavi Yadavalli, Bryan H. Brodek, Malin Fagerås, Samuel Bardsley, Neil Martin, Rajesh Patel, Ioannis Psallidas, the OBERON and TITANIA Trial Investigators* 2026-09-08 Tozorakimab to Prevent COPD Exacerbations In a phase 1–2 study of daraxonrasib, 54% of patients with RAS-mutant non–small-cell lung cancer had grade 3 or higher adverse events, mainly pneumonia, diarrhea, and rash; more than 30% of patients had a response. https://www.nejm.org/doi/full/10.1056/NEJMoa2504059?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2504059 Kathryn C. Arbour, Salman Punekar, Jia Luo, Melissa Johnson, Alexander Spira, Benjamin Herzberg, Alexander Starodub, David Sommerhalder, Joel Randolph Hecht, Ignacio Garrido-Laguna, Minal Barve, Sai-Hong Ignatius Ou, Sumit Kar, Lei Bao, Lin Tao, Rashmi Vora, Aparna Hegde, Andreas Saltos, Nilofer S. Azad, David S. Hong, the RMC-6236-001 Investigators* 2026-09-03 Daraxonrasib for Previously Treated RAS-Mutant Non–Small-Cell Lung Cancer In children with septic shock, no significant difference was seen in the incidence of death, new renal-replacement therapy, or persistent kidney dysfunction with balanced fluid as compared with 0.9% saline for fluid resuscitation. https://www.nejm.org/doi/full/10.1056/NEJMoa2601969?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601969 Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda S. Artis, Atzael B. Campos, Meredith L. Borland, Stuart R. Dalziel, Adriana Yock-Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz, Christopher P. Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah J. Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E. Gripp, Priya G. Jain, Shefali Jani, Gary I. Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, Julia Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, Natalie Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann, the PRoMPT BOLUS Investigators of the PECARN, PERC, and PREDICT Networks* 2026-09-03 Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock This review summarizes the management of pulmonary nodules, with an emphasis on nodule type, imaging follow-up, cancer risk, and strategies to balance timely diagnosis with avoidance of unnecessary procedures. https://www.nejm.org/doi/full/10.1056/NEJMcp2515063?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2515063 Matthew E.J. Callister, Gerard A. Silvestri 2026-09-03 Pulmonary Nodules Improving the clinical treatment of patients with sepsis remains a major focus of critical care physicians worldwide.1,2 To date, few studies in either the pediatric or adult literature have established universal management principles that reliably improve outcomes, which attests to the heterogeneity of this syndrome. Fluid resuscitation is... https://www.nejm.org/doi/full/10.1056/NEJMe2609856?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2609856 Michael F. O’Connor, Juliane Bubeck-Wardenburg 2026-09-03 Fluid Resuscitation in Patients with Sepsis — For Whom the Balance Tolls Catheter-directed thrombolysis led to a lower risk of death, recurrent pulmonary embolism, or cardiorespiratory decompensation or collapse at 7 days than anticoagulation alone in intermediate-high–risk acute pulmonary embolism. https://www.nejm.org/doi/full/10.1056/NEJMoa2608012?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2608012 Josef Kroupa, Martin Radvan, Jan Mrozek, Martin Sluka, Stepan Jirous, Ota Hlinomaz, Milan Pliva, Jan Pudil, Hana Voberkova, Karolina Bartoskova, Martin Poloczek, Martin Kamenik, Michal Brabec, Eva Lichnerova, Martin Hutyra, Ivo Bernat, Martin Novak, Johana Horakova, Lucie Jelinkova, Tomas Knize, Petr Tousek, Cyril Stechovsky, Filip Varhanik, Zdenek Coufal, Jiri Jarkovsky, Viktor Kocka 2026-08-31 Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism In pulmonary hypertension associated with left heart disease and heart failure, pulmonary-artery denervation reduced clinical worsening and recurrent heart failure events as compared with guideline-directed medical therapy alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2609056?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2609056 Hang Zhang, Qiguang Wang, Ming Liang, Xiang Chen, Wei Zhuang, Biao Cheng, Yue Li, Jieyan Shen, Bin Liu, Caojing Zhang, Gangcheng Zhang, Xinxue Liao, Zhenwen Yang, Ruilin He, Yuquan He, Yunshan Cao, Yan Wang, Dajun Chai, Wei Huang, Xiaoping Peng, Wen Gu, Gregg W. Stone, Yaling Han, Shao-Liang Chen, the PADN-HF-PH Investigators* 2026-08-30 Pulmonary Denervation for Heart Failure–Related Pulmonary Hypertension Azithromycin did not lead to a greater reduction in symptom severity than placebo among preschool children presenting to the ED with wheezing, regardless of whether they tested positive for pathogenic bacteria. https://www.nejm.org/doi/full/10.1056/NEJMoa2516505?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516505 Kurt R. Denninghoff, T. Charles Casper, Joseph J. Zorc, Richard M. Ruddy, Sarah Satola, Wendi-Jo Wendt, Claudia R. Morris, Melissa M. Tavarez, Matthew J. Lipshaw, Maria Y. Kwok, Jo-Ann O. Nesiama, Kyle A. Nelson, Michael Webb, Fernando D. Martinez, the PECARN AZ-SWED Trial Study Group* 2026-08-20 Azithromycin for Preschoolers with Wheezing in the Emergency Department Among critically ill adults with acute respiratory failure, neither carbocisteine nor hypertonic saline reduced the duration of mechanical ventilation, and each strategy was associated with harm. https://www.nejm.org/doi/full/10.1056/NEJMoa2603406?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2603406 Bronwen Connolly, Naomi Dickson, Christina Campbell, Judy M. Bradley, Brenda O’Neill, Ashley Agus, Mike Barker, Jeremy S. Bewley, Bronagh Blackwood, Mark Borthwick, Luigi Camporota, Marc Chikhani, Mike Clarke, Paul Dark, Lisa Higgins, Penelope Lambert, Thomas Lunn, Cliona McDowell, Margaret McFarland, Una McShane, Reena Mehta, Ben Messer, Ben Morton, Nehal Patel, Gavin D. Perkins, Deborah Rowley, Murali Shyamsundar, Jonathan A. Silversides, Gordon Sturmey, John Warburton, Barry Williams, Ranjit Lall, Daniel F. McAuley, the MARCH Trial Investigators* 2026-08-20 Carbocisteine or Hypertonic Saline for Acute Respiratory Failure In NSCLC with EGFR exon 20 insertions, first-line sunvozertinib led to longer progression-free survival than chemotherapy. The most common adverse events of grade 3 or higher were elevated creatine kinase, diarrhea, and anemia. https://www.nejm.org/doi/full/10.1056/NEJMoa2604461?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2604461 Caicun Zhou, Laurent Greillier, Geoffrey Liu, Thomas John, Ligang Xing, Dariusz Kowalski, Regan M. Memmott, Ozan Yazici, Meili Sun, Catherine A. Shu, Elvire Pons-Tostivint, Yun Fan, Gonzalo Fernandez-Hinojal, Elaine Shum, Mengzhao Wang, Federica Bertolini, D. Ross Camidge, Chengzhi Zhou, Ludovic Doucet, Qunying Hong, Jian Fang, Dingzhi Huang, Bo Jin, Yan Yu, Lorenzo Antonuzzo, Denis Moro-Sibilot, Jaafar Bennouna, Gilberto de Castro Jr., Li Zheng, John V. Heymach, the WU-KONG28 Investigators* 2026-08-20 First-Line Sunvozertinib in NSCLC with EGFR Exon 20 Insertion Mutations