The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Rheumatology. NEJM (https://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice. https://www.nejm.org/action/showPodcastsFeeds NEJM Group Wed, 17 Jun 2026 02:21:34 GMT 2026 NEJM Group en-us 1440 A 66-year-old man with a history of Crohn’s disease treated with long-term adalimumab presented with fever and swelling of both knees. Analysis of a biopsy sample of the left knee synovium showed an atypical T-cell infiltrate. https://www.nejm.org/doi/full/10.1056/NEJMicm2501877?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2501877 Edward Robert Scheffer Cliff, Melita Kenealy 2026-06-13 Immunosuppression-Associated Peripheral T-Cell Lymphoma A 14-year-old girl was admitted to the hospital because of hypertension and headache. She had hypokalemia, an elevated blood level of C-reactive protein, and an elevated erythrocyte sedimentation rate. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517866 Rachel R. Osborn, Jonathan S. Hausmann, Weizhen Tan, Evan J. Zucker 2026-06-11 Case 16-2026: A 14-Year-Old Girl with Hypertension Among patients with relapsed polymyalgia rheumatica, treatment with secukinumab plus a 24-week glucocorticoid taper resulted in a higher percentage of patients with remission than a glucocorticoid taper alone. https://www.nejm.org/doi/full/10.1056/NEJMoa2602567?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2602567 John H. Stone, Frank Buttgereit, Alain Saraux, Wolfgang A. Schmidt, Christian Dejaco, Robert Spiera, Bhaskar Dasgupta, Edit Drescher, Andrew Jordan, Libor Novosad, Daiki Nakagomi, Yoshinobu Koyama, Sergio Duran-Barragan, Gerald Tracey, Adeline Ruyssen-Witrand, Andrea Rubbert Roth, Juanzhi Fang, Jennifer Ng, Renuka Hiremath, Roselyne Raffner, Ruvie Martin, Silvia Napoletano, Songqiao Huang, Julian Storim, Manmath Patekar, the REPLENISH Investigators* 2026-06-03 Phase 3 Trial of Secukinumab in Polymyalgia Rheumatica Since Dr. Phillip Hench reported on the efficacy of glucocorticoids for rheumatoid arthritis in 1949, glucocorticoids have saved many lives and have offered relief to countless patients. Glucocorticoids have been used as the mainstay of treatment for many immune-mediated inflammatory diseases, including polymyalgia rheumatica and giant-cell arteritis (GCA), owing to... https://www.nejm.org/doi/full/10.1056/NEJMe2605851?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2605851 Yoshiya Tanaka 2026-06-03 Emerging Era for Polymyalgia Rheumatica and GCA — Interleukin-17A Targeting In a phase 3 trial, obexelimab led to a lower risk of disease flares than placebo among patients with IgG4-related disease. Glucocorticoid use was lower and the incidence of remission was higher with obexelimab than with placebo. https://www.nejm.org/doi/full/10.1056/NEJMoa2601337?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2601337 Emanuel Della-Torre, Matthew C. Baker, Wen Zhang, Cory A. Perugino, Guy Katz, Yoshiya Tanaka, Arezou Khosroshahi, Alexander Kleger, Nicolas Schleinitz, Fernando Martinez-Valle, Hendrik Schulze-Koops, Shingo Nakayamada, Vinciane Rebours, Kazuichi Okazaki, Lingli Dong, Mollie Carruthers, Luke Y.C. Chen, Luca Frulloni, Alireza Meysami, Hiroki Takahashi, Mitsuhiro Kawano, Yanying Liu, Takako Saeki, Mikael Ebbo, Tobias Alexander, Andrés González García, Omer Karadag, Maria Maślińska, Shauna M. Quinn, Allen Poma, Audrey Wells, Thomas J. Greene, John H. Stone, Emma L. Culver, the INDIGO Trial Investigators* 2026-06-02 Obexelimab for the Treatment of IgG4-Related Disease IgG4-related disease has emerged as one of the clearest human models for understanding the role of B-lineage cells in immune-mediated inflammation. Although glucocorticoids remain effective for inducing remission, relapse during tapering is common, cumulative toxic effects are substantial, and durable disease control remains difficult to achieve. Della-Torre et al.1 https://www.nejm.org/doi/full/10.1056/NEJMe2605617?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2605617 Thomas Dörner 2026-06-02 Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease In a trial of brepocitinib in adults with dermatomyositis, the 30-mg dose (but not the 15-mg dose) led to greater improvement on a composite myositis index at 52 weeks than placebo. Serious infections were more frequent with the 30-mg dose. https://www.nejm.org/doi/full/10.1056/NEJMoa2503531?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2503531 Ruth Ann Vleugels, Julie J. Paik, Iazsmin Bauer Ventura, Aaron R. Mangold, Prateek C. Gandiga, Anna Haemel, Hector Chinoy, Yessar M. Hussain, Kumaraswamy Sivakumar, Zoltan Griger, Eun Bong Lee, Francisca Bozan, Chung-Yuan Hsu, Alisa Femia, Mazen M. Dimachkie, Michelle S. Min, Tahseen Mozaffar, Christina Charles-Schoeman, David R. Fernandez, Oluwakemi Onajin, Raquel Campanilho-Marques, Galina Marder, Floranne Ernste, Elena Schiopu, Jason Sluzevich, David Pearson, Stephen Lindsey, Michael Luggen, Michael R. Bubb, Erin Boh, Rashmi Maganti, Latisha Heinlen, Katharina S. Shaw, Matthew D. Cascino, Paul N. Mudd Jr., Jiri Vencovsky, Anthony P. Fernandez, David Fiorentino, Lisa Christopher-Stine, Victoria P. Werth, Rohit Aggarwal, the VALOR Investigators* 2026-05-14 A Phase 3 Trial of Brepocitinib in Dermatomyositis Inflammatory myopathies are typically associated with a myositis-specific autoantibody that determines the diagnosis and prognosis. Myositis subgroups have distinct pathomechanisms that now allow for targeted therapies. https://www.nejm.org/doi/full/10.1056/NEJMra2415426?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMra2415426 Yves Allenbach, Olivier Benveniste 2026-05-14 Inflammatory Myopathies Dermatomyositis is a subgroup of idiopathic inflammatory myopathies — systemic autoimmune disorders that are typically characterized by the involvement of multiple organs, including muscle, skin, joints, lungs, gastrointestinal tract, and heart — all conditions with high morbidity and mortality.1 Treatment of myositis is based on off-label use of... https://www.nejm.org/doi/full/10.1056/NEJMe2604009?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2604009 Ingrid E. Lundberg 2026-05-14 A Phase 3 Trial of Brepocitinib in Dermatomyositis A 50-year-old woman was admitted to the hospital because of vaginal bleeding and anemia. She had a history of fibroids and 1 month of progressive thrombocytopenia. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517864?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517864 Joshua C. Ziperstein, Rashid A. Barnawi, Hanny Al-Samkari, Marcy B. Bolster, Lauren E. Heusinkveld 2026-05-14 Case 14-2026: A 50-Year-Old Woman with Vaginal Bleeding and Anemia A 60-year-old woman with follicular lymphoma was evaluated for swelling and proteinuria that had persisted for 2 weeks. The patient’s plasma was clear at 37°C but turbid at 4°C. A kidney biopsy was performed. https://www.nejm.org/doi/full/10.1056/NEJMicm2513605?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2513605 Noriaki Kawano, Ikuo Kikuchi 2026-04-30 Membranoproliferative Glomerulonephritis Due to Cryoglobulinemia A 76-year-old woman, who had a history of treated hepatitis C virus infection, presented with rapidly progressive kidney failure and a stroke. Palpable purpura on the legs was noted. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2517862?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2517862 Frank B. Cortazar, Meghan E. Sise, Otto Rapalino, Andrew R. Branagan, Claire Trivin-Avillach 2026-04-30 Case 13-2026: A 76-Year-Old Woman with Fatigue, Rash, and Kidney Failure In a randomized trial involving 3208 children with Kawasaki disease, adding prednisolone to standard primary therapy did not reduce the incidence of coronary-artery lesions at 1 month. https://www.nejm.org/doi/full/10.1056/NEJMoa2511478?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2511478 Siyuan Lin, Yuanchen He, Lan He, Yiling Liu, Fangjie Wang, Zhenyu Xiong, Yixiang Lin, Lan Ye, Chen Chu, Feng Wang, Lu Zhao, Yinyin Cao, Yuanzheng Zheng, Qin Huang, Jie Wang, Xuecun Liang, Quming Zhao, Shuna Sun, Yalan Dou, Wennan He, Xiaobi Huang, Jingwei Sun, Xianmei Huang, Yan Li, Yanling Liao, Haitao Lv, Silin Pan, Hua Zhu, Xinjiang An, Xuehua He, Cuifen Zhao, Xiaoyan Liu, Yaofei Hu, Jinhua Piao, Lijun Qin, Xiangyu Dong, Qian Peng, Ce Wang, Shubin Lin, Ping Huang, Rongzhou Wu, Hua Peng, Zipu Li, Duolao Wang, Xiaohui Liu, Weili Yan, Fang Liu, Guoying Huang, the Chinese Kawasaki Disease Collaboration Network* 2026-04-16 Randomized Trial of Adjunctive Prednisolone for Kawasaki Disease A 27-year-old woman presented with a 2-week history of joint pain, fever, sore throat, and a nonpruritic rash that worsened during fever. Laboratory tests showed an elevated ESR and elevated C-reactive protein and ferritin levels. https://www.nejm.org/doi/full/10.1056/NEJMicm2514594?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2514594 Gabrielle Cognacq, Richard Stratton 2026-04-16 Adult-Onset Still’s Disease Kawasaki disease is the most common cause of acquired heart disease in children in the developed world.1 Although Kawasaki disease manifests with acute, transient systemic signs, its long-term morbidity derives from necrotizing vasculitis that predominantly affects the coronary arteries.2,3 The primary goal of therapy during the... https://www.nejm.org/doi/full/10.1056/NEJMe2518759?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMe2518759 Jane C. Burns, Jane W. Newburger 2026-04-16 Glucocorticoids in Kawasaki Disease — Refining Indications and the Science This review summarizes the epidemiology, diagnosis, and management of celiac disease and highlights serologic testing, biopsy confirmation, associated autoimmune conditions, and a gluten-free diet as treatment. https://www.nejm.org/doi/full/10.1056/NEJMcp2415548?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2415548 Joseph A. Murray, Steffen Husby 2026-04-09 Celiac Disease This review summarizes the diagnosis and management of polymyalgia rheumatica in adults older than 50 years of age, emphasizing clinical diagnosis, glucocorticoids as first-line therapy, relapses, and glucocorticoid-sparing options. https://www.nejm.org/doi/full/10.1056/NEJMcp2506817?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcp2506817 Christian Dejaco, Eric L. Matteson 2026-03-12 Polymyalgia Rheumatica In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks. https://www.nejm.org/doi/full/10.1056/NEJMoa2516150?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMoa2516150 Richard A. Furie, Maria Dall’Era, Edward M. Vital, Jay P. Garg, Fedra Irazoque Palazuelos, Adolfina E. Zuta Santillán, Jorge Ravelo-Hernández, Mittermayer B. Santiago, Beatriz Zazueta Montiel, Stella Botha, Piotr Leszczyński, Viviane Angelina de Souza, Sandra A. Sicsik, Luis Bellatin, Asokan Naidoo, Zahir Amoura, Maria Antonietta D’Agostino, Sunil Kumar, Biruh Workeneh, Julie Rae, Huiyan A. Mao, Felix Erblang, Oliver Meier, Justine C. Maller, Anca D. Askanase, the ALLEGORY Trial Investigators* 2026-03-06 Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A diagnosis was made. https://www.nejm.org/doi/full/10.1056/NEJMcpc2513546?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMcpc2513546 Pavan K. Bendapudi, Maximiliano Klug, Sharl S. Azar, Mandakolathur R. Murali, Ayman Al Jurdi 2026-02-19 Case 6-2026: A 91-Year-Old Man with Shortness of Breath, Weight Loss, and Eosinophilia A 63-year-old man presented with a 3-month history of chest tightness, palpitations, and abdominal pain. Laboratory studies showed an elevated erythrocyte sedimentation rate and an elevated C-reactive protein level. https://www.nejm.org/doi/full/10.1056/NEJMicm2513456?rss=searchAndBrowse https://www.nejm.org/doi/full/10.1056/NEJMicm2513456 Hsien-Tzung Liao, Ching-Lan Wu 2026-02-05 Aortitis Due to Large-Vessel Vasculitis